Protein Alignment CG42346 and LRRC70

DIOPT Version :10

• Sequence 1: NP_001036303.2
• Gene: CG42346 / 3355160
• FlyBaseID: FBgn0259677
• Length: 1817
• Species: Drosophila melanogaster
• Sequence 2: NP_852607.3
• Gene: LRRC70 / 100130733
• HGNCID: 35155
• Length: 622
• Species: Homo sapiens
• Alignment Length: 692
• Identity: 165/692 - (23%)
• Similarity: 271/692 - (39%)
• Gaps: 191/692 - (27%)

  Fly   552 SNLPQL---REVFLSENNILELPADAFTNSTNVDVIYLESNAIAHIDPNVFSTLVNLDHLYLRSN 613
            |::.||   |::......:..:|.: |..||  ..:||..|.|::|:.:..:.|.:|..||
Human    33 SSVCQLCTGRQINCRNLGLSSIPKN-FPEST--VFLYLTGNNISYINESELTGLHSLVALY---- 90

  Fly   614 FIPLLPVTLFDKSTKLTSLSLDNNEIQDLEIGMFRKLEHLREVRLHNNRIRRVRRGVFEPLPSLQ 678
                                |||:.|..:....|.:|.||..:.|:||.|:|:..|:|:.|.:|:
Human    91 --------------------LDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLR 135

  Fly   679 ELHIQKNSIEDIEPQAFHTLENMQHINLQDNQLTVLEDIFPDENSSLLSVQLEANYLHKVHPRTF 743
            .|::|.|.:..:....|:.|.::|::|||.|:||||..                        .||
Human   136 NLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGS------------------------GTF 176

  Fly   744 SRQQKVQIMWLKDNQLTRVERSFFADTPQLGRLYLSDNKIRDIEKDTFVNLLLLQFLDLSGNQLR 808
            .....::|:.|.:|.:.|:..|.|.....|..|||..|.:..:..:.|             ..|:
Human   177 VGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAF-------------EVLK 228

  Fly   809 QLRRDYFAPLQDLEELSLARNHIEAIEGYAFAKLKNLKSLDLSHNPLVQLTRDIFSNEFPLNSLN 873
            .|||           |||:.|.||||:.:||..|.||:.|.|.::.:..:|||.||....|..|.
Human   229 SLRR-----------LSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLI 282

  Fly   874 LGNCSLRKLEQHAFKSLTNLNELNLERNQLNPADIQTLDI--PNLRRLLLSHNNFSYAGSVGIMA 936
            |.:..|..|....|..|.||..|.|:||::...|..|.:.  .:|:.|.||.||.:     .:..
Human   283 LSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLT-----ALHP 342

  Fly   937 GMLDRLRSLQQLSMS------NCSLGQIPDLLFAKNTNLVRLDL-CDN---------RLTQINRN 985
            .:|..|.||..|..:      ||.|..:.|.|   .::.:.|:: |.|         |...|...
Human   343 RVLKPLSSLIHLQANSNPWECNCKLLGLRDWL---ASSAITLNIYCQNPPSMRGRALRYINITNC 404

  Fly   986 IFSGLNVFKELRLCRNELSDFPHI-----AL---YNLSTLESLDLARNQLASIDFFK-------- 1034
            :.|.:||.:...:.::     |||     ||   ::..|.....|...:..:|.|::
Human   405 VTSSINVSRAWAVVKS-----PHIHHKTTALMMAWHKVTTNGSPLENTETENITFWERIPTSPAG 464

  Fly  1035 -------------------------LSGTLNLRQLILRDNKITALSGFNAVNLTQ-LDSVDLSGN 1073
                                     .|.||||.:.....|...::||..::..|| ::.::.:.:
Human   465 RFFQENAFGNPLETTAVLPVQIQLTTSVTLNLEKNSALPNDAASMSGKTSLICTQEVEKLNEAFD 529

  Fly  1074 LLLSLPANFLRHSINL-----------QKVHLSNNRFLQIPSSALSDVSIPRLSWLNLTGNPINR 1127
            :||   |.|:...:.:           ||:..|.|.    ..:.|...|..:.:..|:|.:
Human   530 ILL---AFFILACVLIIFLIYKVVQFKQKLKASENS----RENRLEYYSFYQSARYNVTAS---- 583

  Fly  1128 IYTVKEERYPYLKELYICQTNLSILTSKDFEAFQALQHLHLV 1169
                            ||.|:.:.|.|...|  |...|..:|
Human   584 ----------------ICNTSPNSLESPGLE--QIRLHKQIV 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42346	NP_001036303.2	LRR	<301..606	CDD:443914	14/56 (25%)
		leucine-rich repeat	303..325	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	351..461	CDD:275380
		leucine-rich repeat	399..422	CDD:275380
		leucine-rich repeat	462..485	CDD:275380
		LRR	486..>736	CDD:443914	48/186 (26%)
		leucine-rich repeat	486..509	CDD:275380
		leucine-rich repeat	510..533	CDD:275380
		leucine-rich repeat	534..556	CDD:275380	1/3 (33%)
		leucine-rich repeat	557..580	CDD:275380	5/25 (20%)
		leucine-rich repeat	581..604	CDD:275380	6/22 (27%)
		leucine-rich repeat	605..628	CDD:275380	3/22 (14%)
		PPP1R42	627..860	CDD:455733	64/232 (28%)
		leucine-rich repeat	629..652	CDD:275380	6/22 (27%)
		leucine-rich repeat	653..676	CDD:275380	9/22 (41%)
		leucine-rich repeat	677..700	CDD:275380	6/22 (27%)
		leucine-rich repeat	701..748	CDD:275380	11/46 (24%)
		leucine-rich repeat	725..736	CDD:275378	0/10 (0%)
		leucine-rich repeat	749..772	CDD:275380	6/22 (27%)
		leucine-rich repeat	773..793	CDD:275380	6/19 (32%)
		leucine-rich repeat	821..844	CDD:275380	11/22 (50%)
		leucine-rich repeat	845..868	CDD:275380	8/22 (36%)
		LRR	869..1226	CDD:443914	79/372 (21%)
		leucine-rich repeat	869..892	CDD:275380	7/22 (32%)
		leucine-rich repeat	893..915	CDD:275380	7/23 (30%)
		leucine-rich repeat	916..944	CDD:275380	8/27 (30%)
		leucine-rich repeat	945..968	CDD:275380	7/28 (25%)
		leucine-rich repeat	969..992	CDD:275380	6/32 (19%)
		leucine-rich repeat	993..1014	CDD:275380	5/28 (18%)
		leucine-rich repeat	1017..1040	CDD:275380	5/55 (9%)
		leucine-rich repeat	1041..1064	CDD:275380	4/22 (18%)
		leucine-rich repeat	1089..1114	CDD:275380	6/35 (17%)
		leucine-rich repeat	1115..1162	CDD:275380	8/46 (17%)
		PPP1R42	1155..1317	CDD:455733	4/15 (27%)
		leucine-rich repeat	1163..1186	CDD:275380	2/7 (29%)
		leucine-rich repeat	1187..1210	CDD:275380
		leucine-rich repeat	1211..1233	CDD:275380
		leucine-rich repeat	1234..1257	CDD:275380
		leucine-rich repeat	1258..1279	CDD:275380
		leucine-rich repeat	1282..1306	CDD:275380
LRRC70	NP_852607.3	LRRNT	31..59	CDD:396168	5/26 (19%)
		LRR	49..>383	CDD:443914	114/416 (27%)
		LRR 1	61..82		7/22 (32%)
		leucine-rich repeat	65..85	CDD:275380	6/19 (32%)
		LRR 2	85..106		8/44 (18%)
		leucine-rich repeat	86..109	CDD:275380	9/46 (20%)
		LRR 3	109..130		9/20 (45%)
		leucine-rich repeat	110..133	CDD:275380	9/22 (41%)
		LRR 4	133..154		5/20 (25%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		LRR 5	157..178		11/44 (25%)
		leucine-rich repeat	158..181	CDD:275380	11/46 (24%)
		LRR 6	181..202		6/20 (30%)
		leucine-rich repeat	182..205	CDD:275380	6/22 (27%)
		LRR 7	205..226		6/33 (18%)
		leucine-rich repeat	206..229	CDD:275380	7/35 (20%)
		LRR 8	229..250		13/31 (42%)
		leucine-rich repeat	230..253	CDD:275380	14/33 (42%)
		LRR 9	253..274		8/20 (40%)
		leucine-rich repeat	254..277	CDD:275380	8/22 (36%)
		LRR 10	277..298		6/20 (30%)
		leucine-rich repeat	278..301	CDD:275380	7/22 (32%)
		LRR 11	301..322		8/20 (40%)
		leucine-rich repeat	302..326	CDD:275380	7/23 (30%)
		LRR 12	326..347		7/25 (28%)
		leucine-rich repeat	327..348	CDD:275380	7/25 (28%)