DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42346 and LRRC70

DIOPT Version :9

Sequence 1:NP_001036303.2 Gene:CG42346 / 3355160 FlyBaseID:FBgn0259677 Length:1817 Species:Drosophila melanogaster
Sequence 2:NP_852607.3 Gene:LRRC70 / 100130733 HGNCID:35155 Length:622 Species:Homo sapiens


Alignment Length:692 Identity:165/692 - (23%)
Similarity:271/692 - (39%) Gaps:191/692 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   552 SNLPQL---REVFLSENNILELPADAFTNSTNVDVIYLESNAIAHIDPNVFSTLVNLDHLYLRSN 613
            |::.||   |::......:..:|.: |..||  ..:||..|.|::|:.:..:.|.:|..||    
Human    33 SSVCQLCTGRQINCRNLGLSSIPKN-FPEST--VFLYLTGNNISYINESELTGLHSLVALY---- 90

  Fly   614 FIPLLPVTLFDKSTKLTSLSLDNNEIQDLEIGMFRKLEHLREVRLHNNRIRRVRRGVFEPLPSLQ 678
                                |||:.|..:....|.:|.||..:.|:||.|:|:..|:|:.|.:|:
Human    91 --------------------LDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLR 135

  Fly   679 ELHIQKNSIEDIEPQAFHTLENMQHINLQDNQLTVLEDIFPDENSSLLSVQLEANYLHKVHPRTF 743
            .|::|.|.:..:....|:.|.::|::|||.|:||||..                        .||
Human   136 NLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGS------------------------GTF 176

  Fly   744 SRQQKVQIMWLKDNQLTRVERSFFADTPQLGRLYLSDNKIRDIEKDTFVNLLLLQFLDLSGNQLR 808
            .....::|:.|.:|.:.|:..|.|.....|..|||..|.:..:..:.|             ..|:
Human   177 VGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAF-------------EVLK 228

  Fly   809 QLRRDYFAPLQDLEELSLARNHIEAIEGYAFAKLKNLKSLDLSHNPLVQLTRDIFSNEFPLNSLN 873
            .|||           |||:.|.||||:.:||..|.||:.|.|.::.:..:|||.||....|..|.
Human   229 SLRR-----------LSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLI 282

  Fly   874 LGNCSLRKLEQHAFKSLTNLNELNLERNQLNPADIQTLDI--PNLRRLLLSHNNFSYAGSVGIMA 936
            |.:..|..|....|..|.||..|.|:||::...|..|.:.  .:|:.|.||.||.:     .:..
Human   283 LSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLT-----ALHP 342

  Fly   937 GMLDRLRSLQQLSMS------NCSLGQIPDLLFAKNTNLVRLDL-CDN---------RLTQINRN 985
            .:|..|.||..|..:      ||.|..:.|.|   .::.:.|:: |.|         |...|...
Human   343 RVLKPLSSLIHLQANSNPWECNCKLLGLRDWL---ASSAITLNIYCQNPPSMRGRALRYINITNC 404

  Fly   986 IFSGLNVFKELRLCRNELSDFPHI-----AL---YNLSTLESLDLARNQLASIDFFK-------- 1034
            :.|.:||.:...:.::     |||     ||   ::..|.....|...:..:|.|::        
Human   405 VTSSINVSRAWAVVKS-----PHIHHKTTALMMAWHKVTTNGSPLENTETENITFWERIPTSPAG 464

  Fly  1035 -------------------------LSGTLNLRQLILRDNKITALSGFNAVNLTQ-LDSVDLSGN 1073
                                     .|.||||.:.....|...::||..::..|| ::.::.:.:
Human   465 RFFQENAFGNPLETTAVLPVQIQLTTSVTLNLEKNSALPNDAASMSGKTSLICTQEVEKLNEAFD 529

  Fly  1074 LLLSLPANFLRHSINL-----------QKVHLSNNRFLQIPSSALSDVSIPRLSWLNLTGNPINR 1127
            :||   |.|:...:.:           ||:..|.|.    ..:.|...|..:.:..|:|.:    
Human   530 ILL---AFFILACVLIIFLIYKVVQFKQKLKASENS----RENRLEYYSFYQSARYNVTAS---- 583

  Fly  1128 IYTVKEERYPYLKELYICQTNLSILTSKDFEAFQALQHLHLV 1169
                            ||.|:.:.|.|...|  |...|..:|
Human   584 ----------------ICNTSPNSLESPGLE--QIRLHKQIV 607

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42346NP_001036303.2 leucine-rich repeat 303..325 CDD:275380
LRR_8 325..384 CDD:290566
leucine-rich repeat 327..350 CDD:275380
leucine-rich repeat 351..461 CDD:275380
LRR_8 373..433 CDD:290566
LRR_RI 397..648 CDD:238064 21/98 (21%)
leucine-rich repeat 399..422 CDD:275380
leucine-rich repeat 462..485 CDD:275380
LRR_8 465..520 CDD:290566
leucine-rich repeat 486..509 CDD:275380
LRR_8 508..567 CDD:290566 4/17 (24%)
leucine-rich repeat 510..533 CDD:275380
LRR_RI 527..785 CDD:238064 61/235 (26%)
leucine-rich repeat 534..556 CDD:275380 1/3 (33%)
LRR_8 555..613 CDD:290566 16/60 (27%)
leucine-rich repeat 557..580 CDD:275380 5/25 (20%)
leucine-rich repeat 581..604 CDD:275380 6/22 (27%)
LRR_8 604..663 CDD:290566 14/58 (24%)
leucine-rich repeat 605..628 CDD:275380 3/22 (14%)
leucine-rich repeat 629..652 CDD:275380 6/22 (27%)
LRR_8 652..711 CDD:290566 21/58 (36%)
leucine-rich repeat 653..676 CDD:275380 9/22 (41%)
leucine-rich repeat 677..700 CDD:275380 6/22 (27%)
leucine-rich repeat 701..748 CDD:275380 11/46 (24%)
leucine-rich repeat 725..736 CDD:275378 0/10 (0%)
leucine-rich repeat 749..772 CDD:275380 6/22 (27%)
LRR_8 771..831 CDD:290566 14/59 (24%)
leucine-rich repeat 773..793 CDD:275380 6/19 (32%)
LRR_RI 804..1076 CDD:238064 82/331 (25%)
LRR_8 821..903 CDD:290566 33/81 (41%)
leucine-rich repeat 821..844 CDD:275380 11/22 (50%)
leucine-rich repeat 845..868 CDD:275380 8/22 (36%)
leucine-rich repeat 869..892 CDD:275380 7/22 (32%)
leucine-rich repeat 893..915 CDD:275380 7/23 (30%)
leucine-rich repeat 916..944 CDD:275380 8/27 (30%)
leucine-rich repeat 945..968 CDD:275380 7/28 (25%)
LRR_8 967..1027 CDD:290566 15/77 (19%)
leucine-rich repeat 969..992 CDD:275380 6/32 (19%)
leucine-rich repeat 993..1014 CDD:275380 5/28 (18%)
LRR_8 1015..1075 CDD:290566 14/93 (15%)
leucine-rich repeat 1017..1040 CDD:275380 5/55 (9%)
leucine-rich repeat 1041..1064 CDD:275380 4/22 (18%)
LRR_RI <1047..1244 CDD:238064 26/135 (19%)
LRR_8 1063..1125 CDD:290566 14/73 (19%)
leucine-rich repeat 1089..1114 CDD:275380 6/35 (17%)
leucine-rich repeat 1115..1162 CDD:275380 8/46 (17%)
LRR_8 1163..1219 CDD:290566 2/7 (29%)
leucine-rich repeat 1163..1186 CDD:275380 2/7 (29%)
leucine-rich repeat 1187..1210 CDD:275380
leucine-rich repeat 1211..1233 CDD:275380
leucine-rich repeat 1234..1257 CDD:275380
LRR_8 1235..1292 CDD:290566
leucine-rich repeat 1258..1279 CDD:275380
leucine-rich repeat 1282..1306 CDD:275380
LRRC70NP_852607.3 LRRNT 31..62 CDD:214470 6/29 (21%)
LRR 1 61..82 7/22 (32%)
leucine-rich repeat 65..85 CDD:275380 6/19 (32%)
LRR_8 85..144 CDD:290566 23/82 (28%)
LRR 2 85..106 8/44 (18%)
leucine-rich repeat 86..109 CDD:275380 9/46 (20%)
LRR 3 109..130 9/20 (45%)
leucine-rich repeat 110..133 CDD:275380 9/22 (41%)
LRR_8 133..192 CDD:290566 20/82 (24%)
LRR 4 133..154 5/20 (25%)
leucine-rich repeat 134..157 CDD:275380 6/22 (27%)
LRR 5 157..178 11/44 (25%)
leucine-rich repeat 158..181 CDD:275380 11/46 (24%)
LRR_RI <159..340 CDD:238064 68/233 (29%)
LRR 6 181..202 6/20 (30%)
LRR_8 182..240 CDD:290566 20/81 (25%)
leucine-rich repeat 182..205 CDD:275380 6/22 (27%)
LRR 7 205..226 6/33 (18%)
leucine-rich repeat 206..229 CDD:275380 7/35 (20%)
LRR_8 228..288 CDD:290566 26/70 (37%)
LRR 8 229..250 13/31 (42%)
leucine-rich repeat 230..253 CDD:275380 14/33 (42%)
LRR 9 253..274 8/20 (40%)
leucine-rich repeat 254..277 CDD:275380 8/22 (36%)
LRR_8 277..337 CDD:290566 20/59 (34%)
LRR 10 277..298 6/20 (30%)
leucine-rich repeat 278..301 CDD:275380 7/22 (32%)
LRR 11 301..322 8/20 (40%)
leucine-rich repeat 302..326 CDD:275380 7/23 (30%)
LRR 12 326..347 7/25 (28%)
leucine-rich repeat 327..348 CDD:275380 7/25 (28%)
LRRCT 359..398 CDD:214507 8/41 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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