Protein Alignment scro and NKX6-2

DIOPT Version :10

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_796374.2
• Gene: NKX6-2 / 84504
• HGNCID: 19321
• Length: 277
• Species: Homo sapiens
• Alignment Length: 216
• Identity: 61/216 - (28%)
• Similarity: 86/216 - (39%)
• Gaps: 60/216 - (27%)

  Fly   114 TPFSVTDILS-PIEESYRKLELNGNPPSPFRSNSSSSSINSPGTLTTSTMANPYAMGTLYHSPGV 177
            ||..::|||. |:..:...| |.|.|    |.|..:||..                  :|..|..
Human    56 TPHGISDILGRPVGAAGGGL-LGGLP----RLNGLASSAG------------------VYFGPAA 97

  Fly   178 QTYCG-PTDNLSLAGHYTDMRNSASW----YGSTANDPRFAISRLMSSSASGTMSHMGNMSGLAA 237
            ....| |.....|.|     |....|    .|:...|||.|    ..:.|.|.:...|
Human    98 AVARGYPKPLAELPG-----RPPIFWPGVVQGAPWRDPRLA----GPAPAGGVLDKDG------- 146

  Fly   238 CSVSDSKPLQFPLAQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQ 302
                          :::..|..|:..|::.||:.|:|.:||:.|||..||..:.:|.:|||:|||
Human   147 --------------KKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQ 197

  Fly   303 NHRYKC-KRQAKEKAMAEQNQ 322
            |.|.|. ||.|.|.|.|::.|
Human   198 NRRTKWRKRHAVEMASAKKKQ 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	24/56 (43%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4	89..142		15/79 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..155		5/47 (11%)
		Homeodomain	147..205	CDD:459649	24/57 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..250		4/9 (44%)