DRSC/TRiP Functional Genomics Resources

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Protein Alignment scro and NANOG

DIOPT Version :10

Sequence 1:NP_001015473.1 Gene:scro / 3355151 FlyBaseID:FBgn0287186 Length:468 Species:Drosophila melanogaster
Sequence 2:NP_079141.2 Gene:NANOG / 79923 HGNCID:20857 Length:305 Species:Homo sapiens


Alignment Length:274 Identity:72/274 - (26%)
Similarity:119/274 - (43%) Gaps:50/274 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   181 CGPTDNLSLAGHYTDMRNSASW--YGSTANDPRFAISRLMSSSASGTMSHMGNMSGLAACSVS-- 241
            |||.:|      |..::.|::.  :..|.:....::..|:..|...:.|..|.....|..||:  
Human    29 CGPEEN------YPSLQMSSAEMPHTETVSPLPSSMDLLIQDSPDSSTSPKGKQPTSAEKSVAKK 87

  Fly   242 -DSKPLQFPLAQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHR 305
             |..|:     :::|.|.:|:..|:..|..||::|:|||..:.:.|:::::|:..|||.||||.|
Human    88 EDKVPV-----KKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQR 147

  Fly   306 YKCKRQAKEKAMAEQNQHNQPASSPRRVAVPVLVKDGKPC----SGN---------NSSSQSQQH 357
            .|.||..|.......|...|.||:|...::......|  |    :||         |:|:.|.| 
Human   148 MKSKRWQKNNWPKNSNGVTQKASAPTYPSLYSSYHQG--CLVNPTGNLPMWSNQTWNNSTWSNQ- 209

  Fly   358 GTNSTSAGNN---------TGSANNGNANSGIVSVTANVSGGLNLITGDAPNSHSPDTSSSLLAS 413
             |.:..:.:|         |.|.||...||...:....   .|.......|||.:.|..::|.|:
Human   210 -TQNIQSWSNHSWNTQTWCTQSWNNQAWNSPFYNCGEE---SLQSCMQFQPNSPASDLEAALEAA 270

  Fly   414 YGTVGGSNVAMLQQ 427
                 |..:.::||
Human   271 -----GEGLNVIQQ 279

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scroNP_001015473.1 Homeodomain 254..310 CDD:459649 22/55 (40%)
NANOGNP_079141.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96 16/77 (21%)
COG5576 74..191 CDD:227863 38/123 (31%)
Homeodomain 97..152 CDD:459649 22/54 (41%)
Required for DNA-binding. /evidence=ECO:0000269|PubMed:25825768 122..151 11/28 (39%)
8 X repeats starting with a Trp in each unit 196..240 12/45 (27%)
Sufficient for transactivation activity. /evidence=ECO:0000250 196..240 12/45 (27%)
Sufficient for strong transactivation activity. /evidence=ECO:0000250 241..305 10/47 (21%)

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