Protein Alignment scro and NKX2-1

DIOPT Version :9

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_001073136.1
• Gene: NKX2-1 / 7080
• HGNCID: 11825
• Length: 401
• Species: Homo sapiens
• Alignment Length: 415
• Identity: 168/415 - (40%)
• Similarity: 206/415 - (49%)
• Gaps: 86/415 - (20%)

  Fly   101 SQHQSTLFNSNHSTPFSVTDILSPIEESYRKLELNGN----PPSPFRSNSSS--------SSINS 153
            |:.:....:..|:|||||:|||||:||||:|:.:.|.    |.:.:|...::        .::..
Human    26 SRRRIMSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGH 90

  Fly   154 PGTLTTSTMANPYAMGTLYHSPGVQTYC-GPTDNLSLAGHYTD-MRNSAS---WYGSTANDPRF- 212
            .|.:|.:.......:..|.|| .|..|| |...|:|....|.| ||||||   |||:.. ||||
Human    91 HGAVTAAYHMTAAGVPQLSHS-AVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANP-DPRFP 153

  Fly   213 AISRLMSSSASGTMSHMGNMSGLAACSVSDSKPLQFPLAQRRKRRVLFTQAQVYELERRFKQQRY 277
            ||||.|..::...||.||.:..|...| .:..||  |.|.||||||||:||||||||||||||:|
Human   154 AISRFMGPASGMNMSGMGGLGSLGDVS-KNMAPL--PSAPRRKRRVLFSQAQVYELERRFKQQKY 215

  Fly   278 LSAPEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKEKAMAEQ-----------------NQHNQ 325
            |||||||||||:||||||||||||||||||.|||||:||..:|                 .|...
Human   216 LSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQA 280

  Fly   326 PASSPRRVAVPVLVKDGKPC----------SGNNSSSQSQQHGTNSTSAGNNTGSANNGNANSGI 380
            ...|||||||||||||||||          |....:.|..||...:..|.....|..:|.|
Human   281 QQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGA---- 341

  Fly   381 VSVTANVSGGLNLITGDAPNS--HSPDTSSSLLASYGTVGGSNVAMLQQPCNNTLMSNSLAMAYR 443
                     ||....|..|.|  .|||     ||.:    .::.|.||...::....||....|.
Human   342 ---------GLGAHPGHQPGSAGQSPD-----LAHH----AASPAALQGQVSSLSHLNSSGSDYG 388

  Fly   444 NQNNFISNGHQQQCGGYLPLQGRAW 468
            ..:          |...  |.||.|
Human   389 TMS----------CSTL--LYGRTW 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeobox	256..309	CDD:278475	49/52 (94%)
NKX2-1	NP_001073136.1	Homeobox	194..247	CDD:278475	49/52 (94%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143182
Domainoid	1	1.000	114	1.000	Domainoid score	I6085
eggNOG	1	0.900	-	-		E2759_KOG0842
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	221	1.000	Inparanoid score	I3557
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002967
OrthoInspector	1	1.000	-	-		otm41843
orthoMCL	1	0.900	-	-		OOG6_108513
Panther	1	1.100	-	-	O	PTHR24340
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2571
SonicParanoid	1	1.000	-	-		X524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780