Protein Alignment scro and NKX2-4

DIOPT Version :9

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_149416.1
• Gene: NKX2-4 / 644524
• HGNCID: 7837
• Length: 354
• Species: Homo sapiens
• Alignment Length: 295
• Identity: 141/295 - (47%)
• Similarity: 171/295 - (57%)
• Gaps: 49/295 - (16%)

  Fly   112 HSTPFSVTDILSPIEESYRKLE--LNGNPP---------SPFRS---NSSSSSINSPGTLTTSTM 162
            |:|||||:||||||||:|:|..  ::|.||         :.:|:   ..||.:....|...:..|
Human     7 HTTPFSVSDILSPIEETYKKFSGAMDGAPPGLGAPLGAAAAYRAPPPGPSSQAATVAGMQPSHAM 71

  Fly   163 AN------------PYAMGTLYH-SPGVQ--------TYC-GPTDNLSLAGHYTD-MRNSAS--W 202
            |.            ..|....|| .|||.        :|| |...|:.....||| ||..|:  |
Human    72 AGHNAAAAAAAAAAAAAAAATYHMPPGVSQFPHGAMGSYCNGGLGNMGELPAYTDGMRGGAATGW 136

  Fly   203 YGSTANDPRF-AISRLMSSSASGTMSHMGNMSGL--AACSVSDSKPLQFPLAQRRKRRVLFTQAQ 264
            ||:.. |||: :|||.|..||...::.||:::|:  ||.|:..........|.||||||||:|||
Human   137 YGANP-DPRYSSISRFMGPSAGVNVAGMGSLTGIADAAKSLGPLHAAAAAAAPRRKRRVLFSQAQ 200

  Fly   265 VYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKEKAMAEQNQHN----- 324
            |||||||||||:||||||||||||:||||||||||||||||||.|||||:||..:..|..
Human   201 VYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQLQQEGGLGPP 265

  Fly   325 -QPASSPRRVAVPVLVKDGKPCSGNNSSSQSQQHG 358
             .|..|||||||||||||||||....|:....|.|
Human   266 PPPPPSPRRVAVPVLVKDGKPCQNGASTPTPGQAG 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeobox	256..309	CDD:278475	49/52 (94%)
NKX2-4	NP_149416.1	Homeobox	192..245	CDD:278475	49/52 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	246..329		28/55 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143167
Domainoid	1	1.000	114	1.000	Domainoid score	I6085
eggNOG	1	0.900	-	-		E2759_KOG0842
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41526
Inparanoid	1	1.050	221	1.000	Inparanoid score	I3557
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1348801at2759
OrthoFinder	1	1.000	-	-		FOG0002967
OrthoInspector	1	1.000	-	-		otm41843
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24340
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2571
SonicParanoid	1	1.000	-	-		X524
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.890