Protein Alignment scro and NKX1-1

DIOPT Version :10

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_001277008.1
• Gene: NKX1-1 / 54729
• HGNCID: 24975
• Length: 448
• Species: Homo sapiens
• Alignment Length: 415
• Identity: 95/415 - (22%)
• Similarity: 125/415 - (30%)
• Gaps: 174/415 - (41%)

  Fly   114 TPFSVTDILSPIEESYRKLE-------------------------LNGNPP-------------- 139
            |.|||.|||.|.:.:.|:..                         .:|.||
Human    80 TSFSVLDILDPNKFNSRRRRCVLLGPVAPAACAPCASAPCAPAPAASGRPPRAEELERRALAGAG 144

  Fly   140 -------------SPFRSNSSSSSINSPGTLTTSTMANPYAMGTLYHSP---------------- 175
                         .||::..:.         |..|  |.|:.|...|||
Human   145 GVGAAGAEPPNAGDPFKAGEAE---------TNDT--NGYSSGGGGHSPSADSGDEVPDDEDDDE 198

  Fly   176 ----------GVQTYCGPTDNLSLAGH------YTDMRNSASWYGSTANDPRFAISRLMSSSASG 224
                      |.:...|....|...|.      .||....|:...:.|..|| ..|.:......|
Human   199 DEAPETEAARGAEEARGGGGGLGARGSGCQGAAETDASPGATVDEAAAPGPR-ENSPVAQGPPGG 262

  Fly   225 TMSHMG---NMSGLAACSV-------SDSKPLQFPLAQRRKRRVLFTQAQVYELERRFKQQRYLS 279
            ..:..|   ...|.|..:.       ||||.     .:.|:.|..||..|:..||.:||..||||
Human   263 AAAPGGAGTTPQGTATAAKPKRKRTGSDSKS-----GKPRRARTAFTYEQLVALENKFKATRYLS 322

  Fly   280 APEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKEKAMAEQNQHNQPASSPRRVAVPVLVKDGKP 344
            ..||.:||..:.||.|||||||||.|.|.|:|                 :|
Human   323 VCERLNLALSLSLTETQVKIWFQNRRTKWKKQ-----------------NP-------------- 356

  Fly   345 CSGNNSSSQSQQHGTNSTSAGNNTGSANNGNANSGIVSVTANVSGGLNLITGDAPNSHSPDTSSS 409
              |.::|:.:...|.....||..||                 :.|||      :|.|.||...:.
Human   357 --GADTSAPTGGGGGPGPGAGPGTG-----------------LPGGL------SPLSPSPPMGAP 396

  Fly   410 LLASYGTVG------GSNVAMLQQP 428
             |..:|..|      |..|...|.|
Human   397 -LGMHGPAGYPAHGPGGLVCAAQLP 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	30/55 (55%)
NKX1-1	NP_001277008.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..80		95/415 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..299		33/200 (17%)
		Homeodomain	297..353	CDD:459649	30/55 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..397		18/103 (17%)