Protein Alignment scro and NANOGP8

DIOPT Version :10

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_001342210.1
• Gene: NANOGP8 / 388112
• HGNCID: 23106
• Length: 305
• Species: Homo sapiens
• Alignment Length: 274
• Identity: 72/274 - (26%)
• Similarity: 119/274 - (43%)
• Gaps: 50/274 - (18%)

  Fly   181 CGPTDNLSLAGHYTDMRNSASW--YGSTANDPRFAISRLMSSSASGTMSHMGNMSGLAACSVS-- 241
            |||.:|      |..::.|::.  :..|.:....::..|:..|...:.|..|.....|..||:
Human    29 CGPEEN------YPSLQMSSAEMPHTETVSPLPSSMDLLIQDSPDSSTSPKGKQPTSAENSVAKK 87

  Fly   242 -DSKPLQFPLAQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHR 305
             |..|:     :::|.|.:|:..|:..|..||::|:|||..:.:.|:::::|:..|||.||||.|
Human    88 EDKVPV-----KKQKTRTVFSSTQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQR 147

  Fly   306 YKCKRQAKEKAMAEQNQHNQPASSPRRVAVPVLVKDGKPC----SGN---------NSSSQSQQH 357
            .|.||..|.......|...|.||:|...::......|  |    :||         |:|:.|.|
Human   148 MKSKRWQKNNWPKNSNGVTQKASAPTYPSLYSSYHQG--CLVNPTGNLPMWSNQTWNNSTWSNQ- 209

  Fly   358 GTNSTSAGNN---------TGSANNGNANSGIVSVTANVSGGLNLITGDAPNSHSPDTSSSLLAS 413
             |.:..:.:|         |.|.||...||...:....   .|.......|||.:.|..::|.|:
Human   210 -TQNIQSWSNHSWNTQTWCTQSWNNQAWNSPFYNCGEE---SLQSCMHFQPNSPASDLEAALEAA 270

  Fly   414 YGTVGGSNVAMLQQ 427
                 |..:.::||
Human   271 -----GEGLNVIQQ 279

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	22/55 (40%)
NANOGP8	NP_001342210.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..96		16/77 (21%)
		Homeodomain	97..152	CDD:459649	22/54 (41%)
		8 X repeats starting with a Trp in each unit	196..240		12/45 (27%)
		Sufficient for transactivation activity. /evidence=ECO:0000250	196..240		12/45 (27%)
		Sufficient for strong transactivation activity. /evidence=ECO:0000250	241..305		10/47 (21%)