Protein Alignment scro and Nkx2-2

DIOPT Version :10

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_001178833.1
• Gene: Nkx2-2 / 366214
• RGDID: 1308443
• Length: 273
• Species: Rattus norvegicus
• Alignment Length: 293
• Identity: 108/293 - (36%)
• Similarity: 128/293 - (43%)
• Gaps: 97/293 - (33%)

  Fly   110 SNHSTPFSVTDIL--------------SPIEESYRKLELNGNPPSPFRSNSSSSSINSPGTLTT- 159
            :|..|.|||.|||              .|.||:      .|..|:........|::::..:|..
  Rat     4 TNTKTGFSVKDILDLPDTNDEEGSVAEGPEEEN------EGPEPAKRAGPLGQSALDAVQSLPLK 62

  Fly   160 ----STMANPYAM------GTLYHSPGVQTYCGPTDNLSLAGHYTDMRNSASWYGSTANDPRFAI 214
                .:..|||..      |..|...|:.....|.|
  Rat    63 SPFYDSSDNPYTRWLASTEGLQYSLHGLAASAPPQD----------------------------- 98

  Fly   215 SRLMSSSASGTMSHMGNMSGLAACSVSDSKPLQ---FPLAQRRKRRVLFTQAQVYELERRFKQQR 276
                |||.|...|        |..|..:.|..|   ....::|||||||::||.|||||||:|||
  Rat    99 ----SSSKSPEPS--------ADESPDNDKETQGGGGDAGKKRKRRVLFSKAQTYELERRFRQQR 151

  Fly   277 YLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKEKAMAEQNQHNQPASSPRRVAVPVLVKD 341
            ||||||||||||||.||||||||||||||||.||     |.||:.....|..|||||||||||:|
  Rat   152 YLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKR-----ARAEKGMEVTPLPSPRRVAVPVLVRD 211

  Fly   342 GKPCSGNNS-----------------SSQSQQH 357
            ||||....:                 |:||.||
  Rat   212 GKPCHALKAQDLAAATFQAGIPFSAYSAQSLQH 244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	49/55 (89%)
Nkx2-2	NP_001178833.1	Homeodomain	129..185	CDD:459649	49/55 (89%)