Protein Alignment scro and PDX1

DIOPT Version :10

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 59/296 - (19%)
• Similarity: 92/296 - (31%)
• Gaps: 127/296 - (42%)

  Fly    82 AVAHHHHNLSSIHHLQNLHSQHQSTLFNSNHSTPFSVTDILSPIEESYRKLELNGNPPSPFRSNS 146
            ||||.||:|.:                                      :|.|...|..||...:
Human    78 AVAHLHHHLPA--------------------------------------QLALPHPPAGPFPEGA 104

  Fly   147 SSSSINSPGTLTTSTMANPYAMGTLYHSPGVQTYCGPTDNLSLAGHYTDMRNSASWYGSTANDPR 211
            ....:..|..:   .:..|:...|..|                           :|.|..|
Human   105 EPGVLEEPNRV---QLPFPWMKSTKAH---------------------------AWKGQWA---- 135

  Fly   212 FAISRLMSSSASGTMSHMGNMSGLAACSVSDSKPLQFPLAQRRKRRVLFTQAQVYELERRFKQQR 276
                                 .|..|....::|          :.|..:|:||:.|||:.|...:
Human   136 ---------------------GGAYAAEPEENK----------RTRTAYTRAQLLELEKEFLFNK 169

  Fly   277 YLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKEK----------AMAEQNQHNQPASSPR 331
            |:|.|.|..||.:::||...:||||||.|.|.|::..:|          .:||..|.....|...
Human   170 YISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRGGGTAVGGGGVAEPEQDCAVTSGEE 234

  Fly   332 RVAV--------------PVLVKDGKPCSGNNSSSQ 353
            .:|:              ||..::|:...|.::|.|
Human   235 LLALPPPPPPGGAVPPAAPVAAREGRLPPGLSASPQ 270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	24/55 (44%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71
		Antp-type hexapeptide	118..123		1/4 (25%)
		Homeodomain	147..203	CDD:459649	25/65 (38%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		2/5 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		13/70 (19%)