Protein Alignment scro and HLX

DIOPT Version :10

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_068777.1
• Gene: HLX / 3142
• HGNCID: 4978
• Length: 488
• Species: Homo sapiens
• Alignment Length: 442
• Identity: 104/442 - (23%)
• Similarity: 170/442 - (38%)
• Gaps: 119/442 - (26%)

  Fly    72 QNTVSTAAAAAVAHHHHNLSSIHHLQNLHSQHQSTLFNSNHSTP-FSVTDI-------LSPIEES 128
            :.....:|||..||    |.|:|.    |:..|:...:....|| .:.:::       |||:..:
Human    62 EGLAGASAAALTAH----LGSVHP----HASFQAAARSPLRPTPVVAPSEVPAGFPQRLSPLSAA 118

  Fly   129 Y----------RKLELNGNPPSPFRSNSSSSSINSPGTLTTSTMANPYAMG-------------- 169
            |          ::......||.|.|:.:.     .|....|..:.||:..|
Human   119 YHHHHPQQQQQQQQPQQQQPPPPPRAGAL-----QPPASGTRVVPNPHHSGSAPAPSSKDLKFGI 178

  Fly   170 ----TLYHSPGVQTYCGPTDNLSL------AG-HYTDMRNSASWYGSTANDPRFAISRLMS---S 220
                :....|.|:......|..||      || |.:.::.||..:.::. ||....|.::|   |
Human   179 DRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLSGLQPSAGQFFASL-DPINEASAILSPLNS 242

  Fly   221 SASGTMSH--MGNMSGLAACSVSDSKPLQFPLAQRRKR---RVLFTQAQVYELERRFKQQRYLSA 280
            :...::.|  .....|..|....|:.|..:    :|||   |.:|:..|...||:||:.|:|::.
Human   243 NPRNSVQHQFQDTFPGPYAVLTKDTMPQTY----KRKRSWSRAVFSNLQRKGLEKRFEIQKYVTK 303

  Fly   281 PEREHLASLIHLTPTQVKIWFQNHRYKCK-------RQAKEKAMAEQNQHNQPAS-------SPR 331
            |:|:.||:::.||..|||:||||.|.|.:       ::.|:|...|:.....||:       ||.
Human   304 PDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKEAGEKPSGGAPAADGEQDERSPS 368

  Fly   332 RVAVPVLVKDGKPCSGNNSS---------------SQSQQHGTN-----STSAGNNTGSANNGNA 376
            |       .:|:..|.::.|               |:...|.|.     .|.|.....||.:|.:
Human   369 R-------SEGEAESESSDSESLDMAPSDTERTEGSERSLHQTTVIKAPVTGALITASSAGSGGS 426

  Fly   377 NSGIVSVTANVSGGLNLITGDAPNSHSPDTSSSLLASYGTVGGSNVAMLQQP 428
            :.|         ||.:.....|.:..|..||:...:|.|..|.|.:....||
Human   427 SGG---------GGNSFSFSSASSLSSSSTSAGCASSLGGGGASELLPATQP 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	27/65 (42%)
HLX	NP_068777.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..173		10/59 (17%)
		Homeodomain	273..333	CDD:459649	27/59 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..488		32/155 (21%)