DRSC/TRiP Functional Genomics Resources

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Protein Alignment scro and HHEX

DIOPT Version :10

Sequence 1:NP_001015473.1 Gene:scro / 3355151 FlyBaseID:FBgn0287186 Length:468 Species:Drosophila melanogaster
Sequence 2:NP_002720.1 Gene:HHEX / 3087 HGNCID:4901 Length:270 Species:Homo sapiens


Alignment Length:349 Identity:75/349 - (21%)
Similarity:119/349 - (34%) Gaps:121/349 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 AVKSVSSF--RLASLLRRENDP-----------SAAMKLFRNPDPESTNPKRPFRYSLLCYDIII 54
            |.|.|.:|  |..|:.|..|.|           |..|||::         ||.|..|.||     
Human   149 ASKKVHNFGKRSNSIKRNPNAPVVRRGWLYKQDSTGMKLWK---------KRWFVLSDLC----- 199

  Fly    55 TKLGGSKMF---DELDQVLLHLKTDTRIVPT-EIIFCNVINFFGRGKLPSRALHMFDEMPQYRCQ 115
                   :|   ||.::.:|    .:.::|: :|......:...| |...:|.|. :....|.|.
Human   200 -------LFYYRDEKEEGIL----GSILLPSFQIAMLTAEDHINR-KYAFKAAHP-NMRTYYFCT 251

  Fly   116 RTVKSLNSLLSALLKCGELEKMKERLSSIDEFGKPDACTYNILIHGCSQSGCFDDALKLFDEMVK 180
            .|.|.:...:.|:|                                        ||..:..|.||
Human   252 DTGKEMELWMKAML----------------------------------------DAALVQTEPVK 276

  Fly   181 KKVKPTGVTFGTLIHGLCKDS-RVKEALKM-KHDMLKVYGVRPTVHIYASLIKALCQIGELSFAF 243
            :      :||...:..:..|| ..||...: .|.:|    :||.|..:.. .|.:.:|.|..   
Human   277 R------ITFNFRVDKITTDSASTKETNNIPNHRVL----IRPEVQNHQK-NKEISKIEEKR--- 327

  Fly   244 KLKDEAY----EGKIKVDAAIYSTLISSLIKAGRSNEVSMILEEMSEKGCKPDTVTYN-VLINGF 303
            .|:.|.|    :|:.:....|.|..::||:.           |..|...|.|..|.|. :.:|  
Human   328 ALEAERYGFQKDGQDRPLTKINSVKLNSLLS-----------EYESGPDCPPQNVHYRPINVN-- 379

  Fly   304 CVENDSESANRVLDEMVEKGLKPD 327
              .:|.::.|..|.: |..|..|:
Human   380 --SSDGKAVNVSLAD-VRGGSHPN 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
scroNP_001015473.1 Homeodomain 254..310 CDD:459649 12/56 (21%)
HHEXNP_002720.1 Interaction with SOX13. /evidence=ECO:0000269|PubMed:20028982 1..137
Homeodomain 136..194 CDD:459649 15/53 (28%)
Required for WNT signaling induction. /evidence=ECO:0000269|PubMed:20028982 137..270 37/187 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..270 21/133 (16%)
Blue background indicates that the domain is not in the aligned region.

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