Protein Alignment scro and TLX3

DIOPT Version :10

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_066305.2
• Gene: TLX3 / 30012
• HGNCID: 13532
• Length: 291
• Species: Homo sapiens
• Alignment Length: 313
• Identity: 75/313 - (23%)
• Similarity: 118/313 - (37%)
• Gaps: 63/313 - (20%)

  Fly     1 MSAVKSVSSFRLASLL----------RRENDPSAAMKLFRNPDPESTNPKRPFRYSLLCYDIIIT 55
            :|.:|..|.||....:          |.:..||..:.:        |||.  |..:|..:..||
Human    89 ISPLKYFSDFRPYFTIHDSEFKEYTTRTQAPPSVILGV--------TNPF--FAKTLQHWPHII- 142

  Fly    56 KLGGSKMFDEL-DQV----LLHLKT-DTR--IVPTEIIFCN----VINFFGRG---KLPSRALHM 105
            ::|..|...|: .||    |.:||| |::  :..:...:.|    :|....:|   |.||.|..:
Human   143 RIGDLKPAGEIPKQVKVKKLKNLKTLDSKPGVYTSYKPYLNRDEEIIKQLQKGIQQKRPSEAQSV 207

  Fly   106 -----FDEMPQ---YRCQRTVKSLNSLLSALLKCGELEKMKERLSSIDEFGKPDACTYNILIHGC 162
                 |.|:.|   ...:|.|.||..|..::.......::::.|.  :||.|....|...|..|.
Human   208 ILRRYFLELTQSFIIPLERYVASLMPLQKSISPWKSPPQLRQFLP--EEFMKTLEKTGPQLTSGI 270

  Fly   163 SQS--GCFDDALKL--FDEMVKKKVKPTGVTFGTL-IHGLCKDSRVKEALKMKHDMLKVYGVRPT 222
            ...  |.:...||.  ||...|.:.|........| :..||::..:  ....||..::      |
Human   271 KGDWIGLYRQFLKSPNFDGWFKTRRKEMTQKLEALHLEALCEEDLL--LWIQKHTEVE------T 327

  Fly   223 VHIYASLIKALCQIGELSFAFKLKDEAYEGKIKVDA---AIYSTLISSLIKAG 272
            |.:...|...|.|.|..|...| .|...:.:..:||   |:...|...|:|.|
Human   328 VDLVLKLKNKLLQAGRESLPVK-PDTVEKLRTHIDAIILALPDDLQGILLKTG 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	7/22 (32%)
TLX3	NP_066305.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56
		Homeodomain	167..223	CDD:459649	12/55 (22%)