Protein Alignment scro and Nkx2-1

DIOPT Version :10

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_001390509.1
• Gene: Nkx2-1 / 21869
• MGIID: 108067
• Length: 423
• Species: Mus musculus
• Alignment Length: 371
• Identity: 157/371 - (42%)
• Similarity: 196/371 - (52%)
• Gaps: 60/371 - (16%)

  Fly    93 IHHLQNLHSQHQSTLFNSNHSTPFSVTDILSPIEESYRKLELNGN----PPSPFRSNSSS----- 148
            :|..::..|:.:....:..|:|||||:|||||:||||:|:.:.|.    |.:.:|...::
Mouse    39 VHPTRSALSRRRIMSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAA 103

  Fly   149 ---SSINSPGTLTTSTMANPYAMGTLYHSPGVQTYC-GPTDNLSLAGHYTD-MRNSAS---WYGS 205
               .::...|.:|.:.......:..|.|| .|..|| |...|:|....|.| ||||||   |||:
Mouse   104 MQQHAVGHHGAVTAAYHMTAAGVPQLSHS-AVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGA 167

  Fly   206 TANDPRF-AISRLMSSSASGTMSHMGNMSGLAACSVSDSKPLQFPLAQRRKRRVLFTQAQVYELE 269
            .. |||| ||||.|..::...||.||.:..|...| .:..||  |.|.||||||||:||||||||
Mouse   168 NP-DPRFPAISRFMGPASGMNMSGMGGLGSLGDVS-KNMAPL--PSAPRRKRRVLFSQAQVYELE 228

  Fly   270 RRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKEKAMAEQ-------------- 320
            ||||||:||||||||||||:||||||||||||||||||.|||||:||..:|
Mouse   229 RRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGG 293

  Fly   321 ----NQHNQPASSPRRVAVPVLVKDGKPCSGN-------NSSSQSQQHGTNSTSAGNNTGSANNG 374
                .|......|||||||||||||||||...       :..|.:||.......|.....:|
Mouse   294 AGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQSHAQQQAQQQAQAAQAAAAA--- 355

  Fly   375 NANSGIVSVTANVSGGLNLITGDAPNS--HSPDTSSSLLASYGTVG 418
                  :||.:. ..||....|..|.|  .|||.:....:..|..|
Mouse   356 ------ISVGSG-GAGLGAHPGHQPGSAGQSPDLAHHAASPAGLQG 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	51/55 (93%)
Nkx2-1	NP_001390509.1	Homeodomain	213..269	CDD:459649	51/55 (93%)