Protein Alignment scro and Nkx2-5

DIOPT Version :10

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_032726.1
• Gene: Nkx2-5 / 18091
• MGIID: 97350
• Length: 318
• Species: Mus musculus
• Alignment Length: 373
• Identity: 122/373 - (32%)
• Similarity: 163/373 - (43%)
• Gaps: 82/373 - (21%)

  Fly   114 TPFSVTDILSPIEESYR---------KLELNGNPPSPFRSNSSSSSINSPGTLTTSTMANPYAMG 169
            |||||.|||: :|:..|         :||....|.|...:.....:.:.|....:........||
Mouse    10 TPFSVKDILN-LEQQQRSLASGDLSARLEATLAPASCMLAAFKPEAYSGPEAAASGLAELRAEMG 73

  Fly   170 TLYHSPGVQTYCGPTDNLS---LAGHYTDMRNSASWYGSTANDPRFAISRLMSSSASGTMSHMGN 231
            .....|    .|.|....:   ..|.|.|        ...|.|||.....|.:
Mouse    74 PAPSPP----KCSPAFPAAPTFYPGAYGD--------PDPAKDPRADKKELCA------------ 114

  Fly   232 MSGLAACSVSDSKPLQFPLAQRRKR-RVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPT 295
            :........:::...:.|.|:||:: ||||:||||||||||||||||||||||:.|||::.||.|
Mouse   115 LQKAVELDKAETDGAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTST 179

  Fly   296 QVKIWFQNHRYKCKRQAKEKAMAEQNQHNQPASSPRRVAVPVLVKDGKPCSGNNSSSQSQQHGTN 360
            ||||||||.|||||||.:::.:........||   ||:||||||:|||||.| :.::.:..:|..
Mouse   180 QVKIWFQNRRYKCKRQRQDQTLELLGPPPPPA---RRIAVPVLVRDGKPCLG-DPAAYAPAYGVG 240

  Fly   361 STSAGNNT--GSANNGNANSGIVSVTANVSGGLNLITGDAPNSHSPDTSS--SLLASYGTVGGSN 421
            ..:.|.|.  ..:..|.|.|...|..|..:         ||.:..|..:|  |...::| ||..|
Mouse   241 LNAYGYNAYPYPSYGGAACSPGYSCAAYPA---------APPAAQPPAASANSNFVNFG-VGDLN 295

  Fly   422 VAMLQQPCNNTLMSNSLAMAYRNQNNFISNGHQQQCGGYLPLQG-RAW 468
            .  :|.|                       |..|...|...|.| |||
Mouse   296 T--VQSP-----------------------GMPQGNSGVSTLHGIRAW 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	45/56 (80%)
Nkx2-5	NP_032726.1	Homeodomain	144..194	CDD:459649	41/49 (84%)