Protein Alignment scro and Nkx2-2

DIOPT Version :10

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_035049.1
• Gene: Nkx2-2 / 18088
• MGIID: 97347
• Length: 273
• Species: Mus musculus
• Alignment Length: 284
• Identity: 110/284 - (38%)
• Similarity: 133/284 - (46%)
• Gaps: 79/284 - (27%)

  Fly   110 SNHSTPFSVTDIL--------------SPIEESYRKLELNGNPPSPFRSNSSSSSINSPGTLTTS 160
            :|..|.|||.|||              .|.|||        ..|.|                  :
Mouse     4 TNTKTGFSVKDILDLPDTNDEDGSVAEGPEEES--------EGPEP------------------A 42

  Fly   161 TMANPYAMGTLYHSPGVQTYCGPTDNLSLAGHYTDMRNS--ASWYGSTANDPRFAISRLMSSSAS 223
            ..|.|...|.|   ..||       :|.|...:.|..::  ..|..|| ...::::..| ::||.
Mouse    43 KRAGPLGQGAL---DAVQ-------SLPLKSPFYDSSDNPYTRWLAST-EGLQYSLHGL-AASAP 95

  Fly   224 GTMSHMGNMSGLAACSVSDSKPLQ---FPLAQRRKRRVLFTQAQVYELERRFKQQRYLSAPEREH 285
            ...|...:....|..|..:.|..|   ....::|||||||::||.|||||||:||||||||||||
Mouse    96 PQDSSSKSPEPSADESPDNDKETQGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREH 160

  Fly   286 LASLIHLTPTQVKIWFQNHRYKCKRQAKEKAMAEQNQHNQPASSPRRVAVPVLVKDGKPCSGNNS 350
            |||||.||||||||||||||||.||     |.||:.....|..|||||||||||:|||||....:
Mouse   161 LASLIRLTPTQVKIWFQNHRYKMKR-----ARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKA 220

  Fly   351 -----------------SSQSQQH 357
                             |:||.||
Mouse   221 QDLAAATFQAGIPFSAYSAQSLQH 244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	49/55 (89%)
Nkx2-2	NP_035049.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		18/80 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..131		8/39 (21%)
		Homeodomain	129..185	CDD:459649	49/55 (89%)