Protein Alignment scro and Hoxb13

DIOPT Version :10

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_032293.1
• Gene: Hoxb13 / 15408
• MGIID: 107730
• Length: 286
• Species: Mus musculus
• Alignment Length: 281
• Identity: 56/281 - (19%)
• Similarity: 95/281 - (33%)
• Gaps: 88/281 - (31%)

  Fly   111 NHSTPFS---VTDILSPIEESYRKLELNGN--PPS-----------------PFR---------- 143
            :||:|.:   ....|.| ..:|..|:|.|:  ||.                 |:.
Mouse    29 SHSSPLASHPAAPTLMP-TVNYAPLDLPGSAEPPKQCHPCPGVPQGASPAPVPYGYFGGGYYSCR 92

  Fly   144 -SNSSSSSINSPGTLTTSTMANPYAMGTLYHSPGVQTYCGPTDNLSLAGHYTDMRNSASWYGSTA 207
             |.||.........|.|.....|        :||.:....||:.....|:....:..||:
Mouse    93 VSRSSLKPCAQTAALATYPSETP--------APGEEYPSRPTEFAFYPGYPGPYQPMASY----- 144

  Fly   208 NDPRFAISRLMSSSASGTMSH--------------MGNMSGLAACSVSDSKPLQF-------PLA 251
                ..:|.:.:..|.|...|              .|..:....|....:.|..|       |..
Mouse   145 ----LDVSVVQTLGAPGEPRHDSLLPVDSYQPWALAGGWNSQMCCQGEQNPPGPFWKAAFAEPSV 205

  Fly   252 QR-----------RKRRVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTPTQVKIWFQNHR 305
            |.           ||:|:.:::.|:.||||.:...::::..:|..:::...|:..|:.|||||.|
Mouse   206 QHPPPDGCAFRRGRKKRIPYSKGQLRELEREYAANKFITKDKRRKISAATSLSERQITIWFQNRR 270

  Fly   306 YKCKRQAKEKAMAEQNQHNQP 326
            .|     ::|.:|:......|
Mouse   271 VK-----EKKVLAKVKTSTTP 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	18/55 (33%)
Hoxb13	NP_032293.1	HoxA13_N	12..124	CDD:463521	20/103 (19%)
		Homeodomain	219..275	CDD:459649	18/60 (30%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q92826	219..248		8/28 (29%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000250|UniProtKB:Q92826	260..275		8/19 (42%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:Q92826	272..275		1/7 (14%)