Protein Alignment scro and NKX2-5

DIOPT Version :10

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_004378.1
• Gene: NKX2-5 / 1482
• HGNCID: 2488
• Length: 324
• Species: Homo sapiens
• Alignment Length: 337
• Identity: 111/337 - (32%)
• Similarity: 151/337 - (44%)
• Gaps: 80/337 - (23%)

  Fly   114 TPFSVTDILSPIEESYRKLELNGNPPSPFRSNSSSSSINSPGTLTTSTMANPYAMGTLYHSPGVQ 178
            |||||.|||: :|:..|.|...|...:...:..:.||     .:..:.....|| |....:||:
Human    10 TPFSVKDILN-LEQQQRSLAAAGELSARLEATLAPSS-----CMLAAFKPEAYA-GPEAAAPGL- 66

  Fly   179 TYCGPTDNLSLAGHYTDMRNSASWYGST-------------ANDPRFAISRLMSSSASGTMSHMG 230
                |.....| |........||.:.:.             |.|||.....|.:
Human    67 ----PELRAEL-GRAPSPAKCASAFPAAPAFYPRAYSDPDPAKDPRAEKKELCA----------- 115

  Fly   231 NMSGLAACSVSDSKPLQFPLAQRRKR-RVLFTQAQVYELERRFKQQRYLSAPEREHLASLIHLTP 294
             :........:::...:.|.|:||:: ||||:||||||||||||||||||||||:.|||::.||.
Human   116 -LQKAVELEKTEADNAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTS 179

  Fly   295 TQVKIWFQNHRYKCKRQAKEKAMAEQNQHNQPASSPRRVAVPVLVKDGKPCSGNNSSSQSQQHGT 359
            |||||||||.|||||||.:::.:........|....||:||||||:|||||.| :|:..:..:|.
Human   180 TQVKIWFQNRRYKCKRQRQDQTLELVGLPPPPPPPARRIAVPVLVRDGKPCLG-DSAPYAPAYGV 243

  Fly   360 NSTSAGNN---------------------------------TGSANNGNANSGIVSVTANVSGGL 391
            .....|.|                                 |.:|||...|.|:..:.|..|.|:
Human   244 GLNPYGYNAYPAYPGYGGAACSPGYSCTAAYPAGPSPAQPATAAANNNFVNFGVGDLNAVQSPGI 308

  Fly   392 NLITGDAPNSHS 403
                   |.|:|
Human   309 -------PQSNS 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	45/56 (80%)
NKX2-5	NP_004378.1	Homeodomain	145..195	CDD:459649	41/49 (84%)