Protein Alignment scro and NKX2-6

DIOPT Version :10

• Sequence 1: NP_001015473.1
• Gene: scro / 3355151
• FlyBaseID: FBgn0287186
• Length: 468
• Species: Drosophila melanogaster
• Sequence 2: NP_001129743.2
• Gene: NKX2-6 / 137814
• HGNCID: 32940
• Length: 301
• Species: Homo sapiens
• Alignment Length: 343
• Identity: 117/343 - (34%)
• Similarity: 144/343 - (41%)
• Gaps: 100/343 - (29%)

  Fly   113 STPFSVTDIL-------------------SPIEESYRKLELNGNPPSPFRSNSSS-------SSI 151
            ||||||.|||                   ||  |:::.|.::..|......|:..       ...
Human     8 STPFSVKDILRLERERSCPAASPHPRVRKSP--ENFQYLRMDAEPRGSEVHNAGGGGGDRKLDGS 70

  Fly   152 NSPG-------TLTTSTMANPYAMGTLYHSPGVQTYCGPTDNLSLAGHYTDMRNSASWYGSTAND 209
            ..||       .:....|..|        .||:                    |:||..|.....
Human    71 EPPGGPCEAVLEMDAERMGEP--------QPGL--------------------NAASPLGGGTRV 107

  Fly   210 PRFAISRLMSSSASGTMSHMGNMSGLAACSVSDSKPLQFPLAQRRKRRVLFTQAQVYELERRFKQ 274
            |...:                   |.:..||...:..|....||||.||||:||||..|||||||
Human   108 PERGV-------------------GNSGDSVRGGRSEQPKARQRRKPRVLFSQAQVLALERRFKQ 153

  Fly   275 QRYLSAPEREHLASLIHLTPTQVKIWFQNHRYKCKRQAKEKAMAEQNQHNQPASSPRRVAVPVLV 339
            ||||||||||||||.:.||.|||||||||.|||||||.::|:: |...|   ..:||||||||||
Human   154 QRYLSAPEREHLASALQLTSTQVKIWFQNRRYKCKRQRQDKSL-ELAGH---PLTPRRVAVPVLV 214

  Fly   340 KDGKPCSGNNSSSQSQQHGTNSTSAGNNTGSANNGNANSGIVSVTANVSGGLNLITGDAPNSHSP 404
            :|||||.|....:.:   ..:..||..:..|...|.:.       |....|.......||:..:|
Human   215 RDGKPCLGPGPGAPA---FPSPYSAAVSPYSCYGGYSG-------APYGAGYGTCYAGAPSGPAP 269

  Fly   405 DTSSSLLASYG-TVGGSN 421
            .|.   |||.| ..||.|
Human   270 HTP---LASAGFGHGGQN 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
scro	NP_001015473.1	Homeodomain	254..310	CDD:459649	46/55 (84%)
NKX2-6	NP_001129743.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..135		24/161 (15%)
		Homeodomain	133..189	CDD:459649	46/55 (84%)