DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO3 and AGO2

DIOPT Version :9

Sequence 1:	NP_001036627.2	Gene:	AGO3 / 3355150	FlyBaseID:	FBgn0250816	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_174413.2	Gene:	AGO2 / 840016	AraportID:	AT1G31280	Length:	1014	Species:	Arabidopsis thaliana

Alignment Length:	882	Identity:	207/882 - (23%)
Similarity:	346/882 - (39%)	Gaps:	192/882 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 SNQFITSESKENITKKTKGPESEAIASENGLFFPDLIYGSKGSSVNIYCNYLKLTTDESKGVFNY 148
            |.|..||:.||.:    |.|:...:.:..              .||:|.|:.|:..:....:.:|
plant   150 SVQVATSDRKEPM----KRPDRGGVVAVR--------------RVNLYVNHYKVNFNPESVIRHY 196

  Fly   149 EVRFFPPI--------DSVHLRIKYLNDHKDKLGGTKT-FDG-NTLYLPILLPNKMTVFISKAED 203
            :|.....|        :...:|.|...|:.|:.....| :|| ..::..:.||..
plant   197 DVEIKGEIPTKKVSRFELAMVRDKVFTDNPDEFPLAMTAYDGQKNIFSAVELPTG---------- 251

  Fly   204 VELQIRILYKKKEEMRNCTQLYNILFDRVMKV--LNYVKFDRKQFDP------------SRPK-- 252
               ..::.|.|.||||..:..:.|....|:|:  |......|..|:|            ..|.
plant   252 ---SYKVEYPKTEEMRGRSYTFTIKQVNVLKLGDLKEYMTGRSSFNPRDVLQGMDVVMKEHPSKC 313

  Fly   253 IIPLAK----LEVWP------------GYVTAVDEYKGGLMLCCDVS------------------ 283
            :|.:.|    .|..|            ||...:.....||.||.|.|
plant   314 MITVGKSFFTRETEPDEDFRFGVIAAKGYRHTLKPTAQGLSLCLDYSVLAFRKAMSVIEYLKLYF 378

  Fly   284 ----HRILCQKTVLEMLVDLYQQNVEHYQESARKMLVGNIVLTRYNNRTYKINDICFD------Q 338
                .|...::.|.|.|:.| :..|.|.:...:..:||   |:..|.:     ||.||      .
plant   379 NWSDMRQFRRRDVEEELIGL-KVTVNHRKNKQKLTIVG---LSMQNTK-----DIKFDLIDQEGN 434

  Fly   339 NPTCQFEIKTGCTSYVEYYKQYHNINIKDVNQPLIYSIKKSRG--IPAERENLQFC-LIPELCYL 400
            .|..:       ||.|||::..:..:|...:.|.:...|..|.  :|     ::|| |:....|
plant   435 EPPRK-------TSIVEYFRIKYGRHIVHKDIPCLDLGKNGRQNFVP-----MEFCDLVEGQIY- 486

  Fly   401 TGLRDEVRSDNKLMREIATFTRVSPNQRQMALNKFYENVSNTPAAQEILNSWGLSLTNNSNKISG 465
              .:|.:..|:.|.  :...:.|:|.|||..::|..: ..|.|:..||:.::||.:..|...:.|
plant   487 --PKDNLDKDSALW--LKKLSLVNPQQRQRNIDKMIK-ARNGPSGGEIIGNFGLKVDTNMTPVEG 546

  Fly   466 RQMDIEQIYFSKISVSAGRSA------------EFSKHAVTNEMLKVVHLSKWIIIHL---RNYR 515
            |.:....:..::    .||..            ...|..||...: |.|   |.::..   ..:.
plant   547 RVLKAPSLKLAE----RGRVVREEPNPRQNNQWNLMKKGVTRGSI-VKH---WAVLDFTASERFN 603

  Fly   516 QAATSLLDNMKQACESLGMNISNPTMISLDH-------DRIDAYI-----QALRRNITMNTQMVV 568
            :.....:||:...|..|||.:..|.:.....       :.|:..:     :|.|::......:|:
plant   604 KMPNDFVDNLIDRCWRLGMQMEAPIVYKTSRMETLSNGNAIEELLRSVIDEASRKHGGARPTLVL 668

  Fly   569 CICHNRRDDRYAAIKKICCSEIPIPSQ-VINAKTLQNDLKIRSVVQKIVLQMNCKLGGSLWTVKI 632
            | ..:|:||.|..:|.|..:::.:.:| .:.....:...:.|:   .:.|:||.|:|||  .|::
plant   669 C-AMSRKDDGYKTLKWIAETKLGLVTQCFLTGPATKGGDQYRA---NLALKMNAKVGGS--NVEL 727

  Fly   633 P-----FK---NVMICGIDSYHDPSNRGN---SVAAFVASIN-SSYSQWYSKAVVQTKREEIVNG 685
            .     ||   .||..|.|..| |:.|..   |:.|.|.::| ...:::.::.:.|..|:|.:.|
plant   728 MDTFSFFKKEDEVMFIGADVNH-PAARDKMSPSIVAVVGTLNWPEANRYAARVIAQPHRKEEIQG 791

  Fly   686 LSASFEIALKMYRKRNGKLPTNIIIYRDGIGDGQLYTCLNYEIPQFEMVC---GNRIKISYIVVQ 747
            ...:....:|.:.:..||.|..|:|:|||:.|.|....||.|:...::..   |...||:.||.|
plant   792 FGDACLELVKAHVQATGKRPNKIVIFRDGVSDAQFDMVLNVELLDVKLTFEKNGYNPKITVIVAQ 856

  Fly   748 KRINTRIF---SGSGIHLENPLPGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTHYVVLRDDCNY 809
            ||..||.|   :..|....|...|||||..:.....|||:|.|.....||..||||..|.|:..:
plant   857 KRHQTRFFPATNNDGSDKGNVPSGTVVDTKVIHPYEYDFYLCSHHGGIGTSKPTHYYTLWDELGF 921

  Fly   810 GPDIIQKLSYKLCFLYYNWAGTVRIPACCMYAHKLAY 846
            ..|.:|||.:::||.:......|.:.....||..:|:
plant   922 TSDQVQKLIFEMCFTFTRCTKPVSLVPPVYYADMVAF 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	33/142 (23%)
AGO3	NP_001036627.2	Piwi_piwi-like_Euk	412..850	CDD:240016	124/481 (26%)
AGO2	NP_174413.2	PLN03202	137..957	CDD:215631	206/879 (23%)
		ArgoN	164..306	CDD:293095	31/168 (18%)
		ArgoL1	317..366	CDD:285861	11/48 (23%)
		PAZ	383..488	CDD:280352	30/128 (23%)
		Piwi_ago-like	528..963	CDD:240015	115/446 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.880