Protein Alignment AGO3 and piwil2

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_001352553.2
• Gene: piwil2 / 572134
• ZFINID: ZDB-GENE-060526-345
• Length: 1046
• Species: Danio rerio
• Alignment Length: 884
• Identity: 313/884 - (35%)
• Similarity: 480/884 - (54%)
• Gaps: 37/884 - (4%)

  Fly     3 GRGNLLSLFNKNAGNMGKSISSKDHEIDSGLDFNNSESSGERLLSSHNIETDLITTLQHVNISVG 67
            |||        .||:||..:..|...|.:.|.....|...|..:|...............:::||
Zfish   181 GRG--------AAGDMGADLQPKPTIIGASLTPEREEVRSEESISFLGRGFTGFGRAAMPHMTVG 237

  Fly    68 RGRARLIDTLKTDDHTSNQF---ITSESKENITKKTKGPESEAIASENGLFFPDLIYGSKGSSVN 129
            ||.   |..|......:..|   ..|.|.|:.......|....:..|. :..|....|:|||.:.
Zfish   238 RGP---IGPLSPSPSVAAPFSLISASSSSEDAPVAPGTPPKVEVKIET-VKEPLQKIGTKGSPIP 298

  Fly   130 IYCNYLKLTTDESKGVFNYEVRFFPPIDSVHLRIKYLNDHKDKLGGTKTFDGNTLYLPILLPNKM 194
            |..||:.:.. ::..||.|.|.|.|.::|:.:|...:.:|:...|....|||:.||||..|..
Zfish   299 IGSNYIPICC-KNDAVFQYHVTFTPNVESLSMRFGMMKEHRPTTGEVVAFDGSILYLPKRLEE-- 360

  Fly   195 TVFISKAE--------DVELQIRILYKKKEEMRNCTQLYNILFDRVMKVLNYVKFDRKQFDPSRP 251
             |...|||        |:::|:..:.....::  |...||::..||||:|......|..:||:..
Zfish   361 -VVHLKAERKTDNQEIDIKIQLTKILPPSSDL--CIPFYNVVLRRVMKILGLKLVGRNHYDPNAV 422

  Fly   252 KIIPLAKLEVWPGYVTAVDEYKGGLMLCCDVSHRILCQKTVLEMLVDLYQQNVEHYQESARKMLV 316
            .|:...:|:|||||.|::....|||.|..||||::|...:||:::..:||.:.|.:|:...|..|
Zfish   423 VILGKHRLQVWPGYSTSIKHTDGGLYLVVDVSHKVLRNDSVLDVMNLIYQGSRESFQDECTKEFV 487

  Fly   317 GNIVLTRYNNRTYKINDICFDQNPTCQFEIKTG-CTSYVEYYKQYHNINIKDVNQPLIYSIKKSR 380
            |:||:||||||||:|:||.:.::|...|.:..| .|::|:||::.:.|.||:::|||:....|.|
Zfish   488 GSIVITRYNNRTYRIDDIEWSKSPKDTFTLADGSVTTFVDYYRKNYGITIKELDQPLLIHRPKER 552

  Fly   381 GIPAERE-NLQFCLIPELCYLTGLRDEVRSDNKLMREIATFTRVSPNQRQMALNKFYENVSNTPA 444
            ..|..:. ..:..|:|||.::||:.:::|.|.:.|:::.....|...|...:|.:...|:::...
Zfish   553 SRPGGKVITGEILLLPELSFMTGIPEKMRKDFRAMKDLTMHINVGAQQHTQSLKQLLHNINSNNE 617

  Fly   445 AQEILNSWGLSLTNNSNKISGRQMDIEQIYFSKISVSAGRSAEFSKHAVTNEMLKVVHLSKWIII 509
            |...|..||||::.......||.:..|.|.....|.....:.::|:..|.:..:..|.|:.|.:.
Zfish   618 ALSELGRWGLSISQEILVTQGRTLPSETICLHSASFVTSPAVDWSRELVRDPSISTVPLNCWAVF 682

  Fly   510 HLRNYRQAATSLLDNMKQACESLGMNISNPTMISLDHDRIDAYIQALRRNITM--NTQMVVCICH 572
            :.|.....|..|:....:....:||.:..|..:.|..||.:.:::::...:|.  ..|:||||..
Zfish   683 YPRRATDQAEELVTTFSRVAGPMGMRVERPIRVELRDDRTETFVKSIHSQLTSEPRVQLVVCIMT 747

  Fly   573 NRRDDRYAAIKKICCSEIPIPSQVINAKTLQNDLKIRSVVQKIVLQMNCKLGGSLWTVKIPFKNV 637
            ..|||.|:||||:||.:.|:|||.||.:|:....|:|||.|||:||:||||||.||||.:|.|.:
Zfish   748 GNRDDLYSAIKKLCCIQSPVPSQAINVRTISQPQKLRSVAQKILLQINCKLGGELWTVNVPLKYL 812

  Fly   638 MICGIDSYHDPSNRGNSVAAFVASINSSYSQWYSKAVVQTKREEIVNGLSASFEIALKMYRKRNG 702
            |:.|:|.:||.|.:..||..||||:||..::|||:...|...|||:||.......||:.|.:.|.
Zfish   813 MVIGVDVHHDTSKKSRSVMGFVASLNSMLTKWYSRVTFQMPNEEIINGFRVCLLAALQKYYEVNH 877

  Fly   703 KLPTNIIIYRDGIGDGQLYTCLNYEIPQ----FEMVCGNRIKISYIVVQKRINTRIFSGSGIHLE 763
            ..|..|:|||||:.||||.|..:|||||    ||.:.....|:::|||||||:|.::|....|..
Zfish   878 AFPEKIVIYRDGVSDGQLKTVEHYEIPQILKCFETIPNYEPKLAFIVVQKRISTTLYSYGSDHFG 942

  Fly   764 NPLPGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYKLCFLYYNW 828
            .|.||||:|..:|..:..||:|::..:|||...||||:.:.:..|..||.:|:|::|:|.||:||
Zfish   943 TPSPGTVLDHTVTNRDWVDFYLMAHSIRQGCGLPTHYITVYNTANLTPDHLQRLTFKMCHLYWNW 1007

  Fly   829 AGTVRIPACCMYAHKLAYLIGQSIQRDVAEALSEKLFYL 867
            .||:|:||.|.||||||:|.||.:..:.|..||||||:|
Zfish  1008 PGTIRVPAPCKYAHKLAFLSGQYLHSEPAIQLSEKLFFL 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	48/135 (36%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	172/443 (39%)
piwil2	NP_001352553.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35