DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO3 and PIWIL2

DIOPT Version :9

Sequence 1:	NP_001036627.2	Gene:	AGO3 / 3355150	FlyBaseID:	FBgn0250816	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_001129193.1	Gene:	PIWIL2 / 55124	HGNCID:	17644	Length:	973	Species:	Homo sapiens

Alignment Length:	895	Identity:	309/895 - (34%)
Similarity:	481/895 - (53%)	Gaps:	96/895 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 GRG----NLLSLFNKNAGNMGKSISSKDHEIDSGLDFNNSESSGERLLSS---------HNIETD 54
            |||    :||.|        |::......|:|......::.|.|...|||         |:.:..
Human   145 GRGSSDASLLPL--------GRAAGGISREVDKPPCTFSTPSRGPPQLSSPPALPQSPLHSPDRP 201

  Fly    55 LITTLQHVNISVGRGRARLIDTLKTDDHTSNQFITSESKENITKKTKGPESEAIASENGLFFPDL 119
            |:.|::|                             :.||.|.|:
Human   202 LVLTVEH-----------------------------KEKELIVKQ-------------------- 217

  Fly   120 IYGSKGSSVNIYCNYLKLTTDESKGVFNYEVRFFPPIDSVHLRIKYLNDHKDKLGGTKTFDGNTL 184
              ||||:..::..|.:|:.. .::.|:.|.|.|.|.::...:|...|.||:...|....|||:.|
Human   218 --GSKGTPQSLGLNLVKIQC-HNEAVYQYHVTFSPNVECKSMRFGMLKDHQAVTGNVTAFDGSIL 279

  Fly   185 YLPILLPNKMTVFIS-KAEDVELQIRILYKKKEEMRN--CTQLYNILFDRVMKVLNYVKFDRKQF 246
            |||:.|...:.:... |.:..|:.|:|...|..|..:  |...||::|.||||:|:.....|..:
Human   280 YLPVKLQQVLELKSQRKTDSAEISIKIQMTKILEPCSDLCIPFYNVVFRRVMKLLDMKLVGRNFY 344

  Fly   247 DPSRPKIIPLAKLEVWPGYVTAVDEYKGGLMLCCDVSHRILCQKTVLEMLVDLYQQNVEHYQESA 311
            ||:...::...:|::||||..::....|||.|..||||:::....||:::..:||||.||:|:..
Human   345 DPTSAMVLQQHRLQIWPGYAASIRRTDGGLFLLADVSHKVIRNDCVLDVMHAIYQQNKEHFQDEC 409

  Fly   312 RKMLVGNIVLTRYNNRTYKINDICFDQNPTCQFEIKTGC-TSYVEYYKQYHNINIKDVNQPLIYS 375
            .|:||||||:||||||||:|:|:.:::.|...|.:..|. .:::|||.:.:.|.:|:.:|||:
Human   410 TKLLVGNIVITRYNNRTYRIDDVDWNKTPKDSFTMSDGKEITFLEYYSKNYGITVKEEDQPLL-- 472

  Fly   376 IKKSRGIPAERENL-------QFCLIPELCYLTGLRDEVRSDNKLMREIATFTRVSPNQRQMALN 433
            |.:    |:||::.       :..|:|||.::||:.::::.|.:.|:::|....:||.|...||.
Human   473 IHR----PSERQDNHGMLLKGEILLLPELSFMTGIPEKMKKDFRAMKDLAQQINLSPKQHHSALE 533

  Fly   434 KFYENVSNTPAAQEILNSWGLSLTNNSNKISGRQMDIEQIYFSKISVSAGRSAEFSKHAVTNEML 498
            ...:.::...||...|..|||.|..:.:||.||.:.:|:|.....|....:...:.|....:..:
Human   534 CLLQRIAKNEAATNELMRWGLRLQKDVHKIEGRVLPMERINLKNTSFITSQELNWVKEVTRDPSI 598

  Fly   499 KVVHLSKWIIIHLRNYRQAATSLLDNMKQACESLGMNISNPTMISLDHDRIDAYIQALRRNITM- 562
            ..:.:..|.:.:.:.....|..|::.:::....:||.:|.|..:.|..|||:.|::.::..:..
Human   599 LTIPMHFWALFYPKRAMDQARELVNMLEKIAGPIGMRMSPPAWVELKDDRIETYVRTIQSTLGAE 663

  Fly   563 -NTQMVVCICHNRRDDRYAAIKKICCSEIPIPSQVINAKTLQNDLKIRSVVQKIVLQMNCKLGGS 626
             ..||||||....|||.|.||||:||.:.|:||||:|.:|:....::|||.|||:||:||||||.
Human   664 GKIQMVVCIIMGPRDDLYGAIKKLCCVQSPVPSQVVNVRTIGQPTRLRSVAQKILLQINCKLGGE 728

  Fly   627 LWTVKIPFKNVMICGIDSYHDPSNRGNSVAAFVASINSSYSQWYSKAVVQTKREEIVNGLSASFE 691
            ||.|.||.|.:|:.|:|.|||||....||..||||||.:.::|||:.|.|...:|||:.|.....
Human   729 LWGVDIPLKQLMVIGMDVYHDPSRGMRSVVGFVASINLTLTKWYSRVVFQMPHQEIVDSLKLCLV 793

  Fly   692 IALKMYRKRNGKLPTNIIIYRDGIGDGQLYTCLNYEIPQ----FEMVCGNRIKISYIVVQKRINT 752
            .:||.:.:.|..||..|::||||:.||||.|..||||||    ||.....:.|:...||||:|:|
Human   794 GSLKKFYEVNHCLPEKIVVYRDGVSDGQLKTVANYEIPQLQKCFEAFENYQPKMVVFVVQKKIST 858

  Fly   753 RIFSGSGIHLENPLPGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKL 817
            .::..:..:...|.||||||..||.....||:|::..||||...|||||.:.:..|..||.:|:|
Human   859 NLYLAAPQNFVTPTPGTVVDHTITSCEWVDFYLLAHHVRQGCGIPTHYVCVLNTANLSPDHMQRL 923

  Fly   818 SYKLCFLYYNWAGTVRIPACCMYAHKLAYLIGQSIQRDVAEALSEKLFYL 867
            ::|||.:|:||.||:|:||.|.||||||:|.|..:..:.|..|.|.||:|
Human   924 TFKLCHMYWNWPGTIRVPAPCKYAHKLAFLSGHILHHEPAIQLCENLFFL 973

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	50/141 (35%)
AGO3	NP_001036627.2	Piwi_piwi-like_Euk	412..850	CDD:240016	177/443 (40%)
PIWIL2	NP_001129193.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..65
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..199		8/36 (22%)
		ArgoL1	339..386	CDD:312283	16/46 (35%)
		PAZ_piwi_like	387..504	CDD:239211	47/122 (39%)
		Piwi_piwi-like_Euk	512..956	CDD:240016	177/443 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147177
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1042
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H23071
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40457
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3665
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.650