DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO3 and PIWIL3

DIOPT Version :9

Sequence 1:	NP_001036627.2	Gene:	AGO3 / 3355150	FlyBaseID:	FBgn0250816	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_001008496.2	Gene:	PIWIL3 / 440822	HGNCID:	18443	Length:	882	Species:	Homo sapiens

Alignment Length:	813	Identity:	290/813 - (35%)
Similarity:	454/813 - (55%)	Gaps:	51/813 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 KTKGPES---EAIASEN--GLFFPDLIY--------------GSKGSSVNIYCNYLKLTTDESKG 144
            |..|||:   .|...|.  |..|.||:.              ||:|:.|.:..|:.::.:.....
Human    77 KEPGPEAGLHTAPLQERRIGGVFQDLVVNTRQDMKHVKDSKTGSEGTVVQLLANHFRVISRPQWV 141

  Fly   145 VFNYEVRFFPPIDSVHLRIKYLNDHKDKLGGTKTFDGNTLYLPILLPNKMTVFISKAEDVELQIR 209
            .:.|.|.:.|.|:..:||...|:.|:.|.|....||||:|.|...|..:...::|..:|..: ::
Human   142 AYKYNVDYKPDIEDGNLRTILLDQHRRKFGERHIFDGNSLLLSRPLKERRVEWLSTTKDKNI-VK 205

  Fly   210 ILYKKKEEMR----NCTQLYNILFDRVMKVLNYVKFDRKQFDPSRPKIIPL----AKLEVWPGYV 266
            |..:..:|:.    :|.:.|||||.|..|:|::.:..|..:  ::.|.|.|    ..||:|.|||
Human   206 ITVEFSKELTPTSPDCLRYYNILFRRTFKLLDFEQVGRNYY--TKKKAIQLYRHGTSLEIWLGYV 268

  Fly   267 TAVDEYKGGLMLCCDVSHRILCQKTVLEMLV-DLYQQNVEHYQESARKMLVGNIVLTRYNNRTYK 330
            |:|.:|:..:.||.||||::|..:|..:.:. ...|....:.:|.....|:|:||||:|||:||:
Human   269 TSVLQYENSITLCADVSHKLLRIETAYDFIKRTSAQAQTGNIREEVTNKLIGSIVLTKYNNKTYR 333

  Fly   331 INDICFDQNPTCQFEIKTGC-TSYVEYYKQYHNINIKDVNQPLIYSIKK-SRGIP-AERENLQFC 392
            ::||.:.|||...|....|. .:|::||:|.|...:....|||:.|..: .:|:. .:||.:  .
Human   334 VDDIDWKQNPEDTFNKSDGSKITYIDYYRQQHKEIVTVKKQPLLVSQGRWKKGLTGTQREPI--L 396

  Fly   393 LIPELCYLTGLRDEVRSDNKLMREIATFTRVSPNQRQMALNKFYENVSNTPAAQEILNSWGLSLT 457
            |||:||::|||.||:..|..:::|:|..||:||.:|...|.:|...:.:....:|:|..|.|...
Human   397 LIPQLCHMTGLTDEICKDYSIVKELAKHTRLSPRRRHHTLKEFINTLQDNKKVRELLQLWDLKFD 461

  Fly   458 NNSNKISGRQMDIEQIYFSKISVSAGRSAEFSKHAVTNEMLKVVHLSKWIIIHLRNYRQAATSLL 522
            .|...:.||.:....|...:..|.|....::|:......:|..:.|..|:|::.|:..:.|.||.
Human   462 TNFLSVPGRVLKNANIVQGRRMVKANSQGDWSREIRELPLLNAMPLHSWLILYSRSSHREAMSLK 526

  Fly   523 DNMKQACESLGMNISNPTMISLDHDRIDAYIQALRRNITMNTQM---------VVCICHNRRDDR 578
            .:::.....:|:.:....||.:|.| .::||..||:......||         |:||..|....|
Human   527 GHLQSVTAPMGITMKPAEMIEVDGD-ANSYIDTLRKYTRPTLQMGMSCLLVFKVICILPNDDKRR 590

  Fly   579 YAAIKKICCSEIPIPSQVINAKTLQNDLKIRSVVQKIVLQMNCKLGGSLWTVKIPFKNVMICGID 643
            |.:||:..|::.|||||.:..|||:. ::.|::|.||..|||||:||:||.|:...:..|..|||
Human   591 YDSIKRYLCTKCPIPSQCVVKKTLEK-VQARTIVTKIAQQMNCKMGGALWKVETDVQRTMFVGID 654

  Fly   644 SYHDPSNRGNSVAAFVASINSSYSQWYSKAVVQTKREEIVNGLSASFEIALKMYRKRNGKLPTNI 708
            .:||..||..|:|.||||.|:..::|||:.|:|...||:|..|....:.||.::.|....:|.::
Human   655 CFHDIVNRQKSIAGFVASTNAELTKWYSQCVIQKTGEELVKELEICLKAALDVWCKNESSMPHSV 719

  Fly   709 IIYRDGIGDGQLYTCLNYEIPQ----FEMVCGNRIKISYIVVQKRINTRIFSGSGIHLENPLPGT 769
            |:||||:|||||...|::|..:    .:.:..|...:::|||:||||||.|...|.:.:||.|||
Human   720 IVYRDGVGDGQLQALLDHEAKKMSTYLKTISPNNFTLAFIVVKKRINTRFFLKHGSNFQNPPPGT 784

  Fly   770 VVDQHITKSNMYDFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYKLCFLYYNWAGTVRI 834
            |:|..:|::..||||:|||.|:.||||||||.|:.|.....||.:|:|:|.||.:|||..|.:|:
Human   785 VIDVELTRNEWYDFFIVSQSVQDGTVTPTHYNVIYDTIGLSPDTVQRLTYCLCHMYYNLPGIIRV 849

  Fly   835 PACCMYAHKLAYLIGQSIQRDVAEALSEKLFYL 867
            ||.|.||||||||:||||.::...:||.:||||
Human   850 PAPCHYAHKLAYLVGQSIHQEPNRSLSTRLFYL 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	48/137 (35%)
AGO3	NP_001036627.2	Piwi_piwi-like_Euk	412..850	CDD:240016	171/450 (38%)
PIWIL3	NP_001008496.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91		5/13 (38%)
		ArgoN	119..225	CDD:293095	27/106 (25%)
		PAZ_piwi_like	278..408	CDD:239211	47/131 (36%)
		Piwi_piwi-like_Euk	416..865	CDD:240016	171/450 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147174
Domainoid	1	1.000	316	1.000	Domainoid score	I1269
eggNOG	1	0.900	-	-		E1_KOG1042
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	621	1.000	Inparanoid score	I880
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	1	1.000	-	-		FOG0003636
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.810