DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO3 and AGO2

DIOPT Version :9

Sequence 1:	NP_001036627.2	Gene:	AGO3 / 3355150	FlyBaseID:	FBgn0250816	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_730054.1	Gene:	AGO2 / 39683	FlyBaseID:	FBgn0087035	Length:	1217	Species:	Drosophila melanogaster

Alignment Length:	849	Identity:	202/849 - (23%)
Similarity:	332/849 - (39%)	Gaps:	164/849 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 GSKGSSVNIYCNYLKLTTDESKGV-FNYEVRFFPPIDSVHLRIKYLNDHKDKLGG-TKTFDGN-T 183
            |:.|....:..|||.|...:...| ::|:|:..|.......|..:.....|:||| ...:||. :
  Fly   411 GTIGKPGQVGINYLDLDLSKMPSVAYHYDVKIMPERPKKFYRQAFEQFRVDQLGGAVLAYDGKAS 475

  Fly   184 LY----LPILLPN-------------KMTVFISKAEDVELQIRILYKKKEEMRNCTQLYNILFDR 231
            .|    ||:...|             :.|:.|.:..|..:.::.|         .|.:.:.:||:
  Fly   476 CYSVDKLPLNSQNPEVTVTDRNGRTLRYTIEIKETGDSTIDLKSL---------TTYMNDRIFDK 531

  Fly   232 VMKVLNYV-------------KFDRKQFDPSRPKIIPLAKLEVWPGYVTAVDEYKGGLM-----L 278
            .|:.:..|             :..|..|..|.|.    .:.|:..||...|..|:..::     |
  Fly   532 PMRAMQCVEVVLASPCHNKAIRVGRSFFKMSDPN----NRHELDDGYEALVGLYQAFMLGDRPFL 592

  Fly   279 CCDVSHRIL-CQKTVLEMLVDLYQQ-------NVEHYQESARKMLVG-NIVLTRYNN-----RTY 329
            ..|:||:.. ....::|.|.....:       |:::.:......|.| |:|.|...:     |.|
  Fly   593 NVDISHKSFPISMPMIEYLERFSLKAKINNTTNLDYSRRFLEPFLRGINVVYTPPQSFQSAPRVY 657

  Fly   330 KINDICFDQNPTCQFE---IKTGCTSYVE------YYKQYHNINIKDVNQPLIYSIKKSRGIPAE 385
            ::|.:......:..||   .|....||..      .:.|.|.:|:..       |||.
  Fly   658 RVNGLSRAPASSETFEHDGKKVTIASYFHSRNYPLKFPQLHCLNVGS-------SIKS------- 708

  Fly   386 RENLQFCLIP-ELCYL-----TGLRDEVRSDNKLMREIATFTRVSPNQRQMALNKFYENVSNTPA 444
                  .|:| |||.:     ...:|.......:::..||.|.|...:....|..|..|:..|
  Fly   709 ------ILLPIELCSIEEGQALNRKDGATQVANMIKYAATSTNVRKRKIMNLLQYFQHNLDPT-- 765

  Fly   445 AQEILNSWGLSLTNNSNKISGRQMDIEQI-YFSKISVSAGRSAEFSKHAVTNEMLKVV------H 502
                ::.:|:.:.|:...:|.|.:...|: |.||      |.......:...:.:|.:      |
  Fly   766 ----ISRFGIRIANDFIVVSTRVLSPPQVEYHSK------RFTMVKNGSWRMDGMKFLEPKPKAH 820

  Fly   503 LSKWIIIHLRNYRQAATSLLDNMKQACESLGMNISNPTMISLDHD-----------RIDAYIQAL 556
            ....:....|:.|:...:.|::......|.|..::    ||||.|           .:|.....|
  Fly   821 KCAVLYCDPRSGRKMNYTQLNDFGNLIISQGKAVN----ISLDSDVTYRPFTDDERSLDTIFADL 881

  Fly   557 RRNITMNTQMVVCICHNRRDDRYAAIKKICCSEIPIPSQVINAKTLQNDLKIRSVVQKIVLQMNC 621
            :|  :.:...:|.|...|..  |..||:....:..|.:|.|...|::.... ...:..|:|::|.
  Fly   882 KR--SQHDLAIVIIPQFRIS--YDTIKQKAELQHGILTQCIKQFTVERKCN-NQTIGNILLKINS 941

  Fly   622 KLGGSLWTVK----IP-FKNVMICGIDSYH-DPSNRG-NSVAAFVAS---INSSYSQWYSKAVVQ 676
            ||.|....:|    :| .||.|..|.|..| .|..|. .||....||   ..:||:..|  .:.:
  Fly   942 KLNGINHKIKDDPRLPMMKNTMYIGADVTHPSPDQREIPSVVGVAASHDPYGASYNMQY--RLQR 1004

  Fly   677 TKREEIVNGLSASFEIALKMYRKRNGKLPTNIIIYRDGIGDGQLYTCLNYEIPQFEMVC---GNR 738
            ...|||.:..|.:.| .|::|::.....|.:||.||||:.|||.....|.|:...:..|   |.:
  Fly  1005 GALEEIEDMFSITLE-HLRVYKEYRNAYPDHIIYYRDGVSDGQFPKIKNEELRCIKQACDKVGCK 1068

  Fly   739 IKISYIVVQKRINTRIFSGSGIHLENPL----PGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTH 799
            .||..::|.||.:||.|....:...|..    ||||||:.|...|...||:||....|||..||.
  Fly  1069 PKICCVIVVKRHHTRFFPSGDVTTSNKFNNVDPGTVVDRTIVHPNEMQFFMVSHQAIQGTAKPTR 1133

  Fly   800 YVVLRDDCNYGPDIIQKLSYKLCFLYYNWAGTVRIPACCMYAHKLA-----YLIGQSIQRDVAEA 859
            |.|:.:..|...|::|:|:|.||.::.....:|..||....||.:|     ||.|.:...|:.:.
  Fly  1134 YNVIENTGNLDIDLLQQLTYNLCHMFPRCNRSVSYPAPAYLAHLVAARGRVYLTGTNRFLDLKKE 1198

  Fly   860 LSEK 863
            .:::
  Fly  1199 YAKR 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	32/161 (20%)
AGO3	NP_001036627.2	Piwi_piwi-like_Euk	412..850	CDD:240016	129/477 (27%)
AGO2	NP_730054.1	PLN03202	411..1180	CDD:215631	197/825 (24%)
		ArgoN	411..543	CDD:293095	30/140 (21%)
		ArgoL1	554..601	CDD:285861	13/50 (26%)
		PAZ	605..719	CDD:239207	27/133 (20%)
		Piwi_ago-like	764..1186	CDD:240015	120/445 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910