Protein Alignment AGO3 and AGO1

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_725341.1
• Gene: AGO1 / 36544
• FlyBaseID: FBgn0262739
• Length: 984
• Species: Drosophila melanogaster
• Alignment Length: 927
• Identity: 204/927 - (22%)
• Similarity: 364/927 - (39%)
• Gaps: 237/927 - (25%)

  Fly    88 ITSESKENITK--------------------KTKGPESEAIASENGLFFPDL-IY--------GS 123
            :||.|.:|:..                    .|.|..:.|||:......||: ::        |.
  Fly    79 VTSPSAQNVAAGGATVAGAAATAAQVASALGATTGSVTPAIATATPATQPDMPVFTCPRRPNLGR 143

  Fly   124 KGSSVNIYCNYLKLTTDESKGVFNYEVRFFPP----------IDS-VHLRIKYLNDHKDKLGGTK 177
            :|..:.:..|:.::|..... |.:|::...|.          |:: ||...|.....|      .
  Fly   144 EGRPIVLRANHFQVTMPRGY-VHHYDINIQPDKCPRKVNREIIETMVHAYSKIFGVLK------P 201

  Fly   178 TFDG-NTLYL--PILLPNKMTVFISKAEDVELQIRILYKKKEEMRNCT-------QLYN------ 226
            .||| |.||.  |:.:.|         |.:||::.:..:.|:.:...|       .|:|
  Fly   202 VFDGRNNLYTRDPLPIGN---------ERLELEVTLPGEGKDRIFRVTIKWQAQVSLFNLEEALE 257

  Fly   227 -----ILFDRVMKV---------LNYVKFDRKQFDPSRPKIIPL-AKLEVWPGYVTAVDEYKGGL 276
                 |.:|.::.:         :.|....|..|........|| ...|||.|:..:|...:..:
  Fly   258 GRTRQIPYDAILALDVVMRHLPSMTYTPVGRSFFSSPEGYYHPLGGGREVWFGFHQSVRPSQWKM 322

  Fly   277 MLCCDVSHR----------ILCQKTVLEMLVDLYQQ---------------------NVEHYQES 310
            ||..|||..          .:|:  ||: :.|:.:|                     .:.|..:.
  Fly   323 MLNIDVSATAFYKAQPVIDFMCE--VLD-IRDINEQRKPLTDSQRVKFTKEIKGLKIEITHCGQM 384

  Fly   311 ARKMLVGNIVLTRYNNRTYKINDICFDQNPTCQFEIKTG----CTSYVEYYKQYHNINIKDVNQP 371
            .||..|.|:.......:::.:             :::.|    || ..:|:...:.:.::..:.|
  Fly   385 RRKYRVCNVTRRPAQMQSFPL-------------QLENGQTVECT-VAKYFLDKYRMKLRYPHLP 435

  Fly   372 LIY--SIKKSRGIPAERENL---QFCLIPELCYLTGLRDEVRSDNKLMREIATFTRV-----SPN 426
            .:.  ...|...:|.|..|:   |.|:                  |.:.::.|.|.:     |..
  Fly   436 CLQVGQEHKHTYLPLEVCNIVAGQRCI------------------KKLTDMQTSTMIKATARSAP 482

  Fly   427 QRQMALNKFYE--NVSNTPAAQEILNSWGLSLTNNSNKISGRQMDIEQIYF-------------- 475
            .|:..:|...:  :.:|....||    :||:::|:..::.||.:...::.:
  Fly   483 DREREINNLVKRADFNNDSYVQE----FGLTISNSMMEVRGRVLPPPKLQYGGRVSTGLTGQQLF 543

  Fly   476 ---SKISVSAGRSAEFSKHAVTNEMLKVVHLSKWIIIHLRNYRQAATSLLDNMKQACESLGMNIS 537
               :|:|:::.....:....  .:....|.:..|.|......|......|.|..|..:.:..:..
  Fly   544 PPQNKVSLASPNQGVWDMRG--KQFFTGVEIRIWAIACFAPQRTVREDALRNFTQQLQKISNDAG 606

  Fly   538 NPTM-------ISLDHDRIDAYIQALRRNITMNTQMVVCICHNRRDDRYAAIKKICCSEIPIPSQ 595
            .|.:       .:...|:::...:.|:  ||.....:|.:....:...||.:|::..:.:.:.:|
  Fly   607 MPIIGQPCFCKYATGPDQVEPMFRYLK--ITFPGLQLVVVVLPGKTPVYAEVKRVGDTVLGMATQ 669

  Fly   596 VINAKTLQNDLKIRSVVQKIVLQMNCKLGGSLWTVKIPF-------KNVMICGIDSYHDPS--NR 651
            .:.||.:.....  ..:..:.|::|.|||| :.::.:|.       :.|:..|.|..|.|:  |:
  Fly   670 CVQAKNVNKTSP--QTLSNLCLKINVKLGG-INSILVPSIRPKVFNEPVIFLGADVTHPPAGDNK 731

  Fly   652 GNSVAAFVASINSSYSQWYSKAVVQTKREEIVNGLSASF-EIALKMYRKRNGKLPTNIIIYRDGI 715
            ..|:||.|.|:::..|::.:...||..|:||:..||:.. |:.:..|:...|..|..||:||||:
  Fly   732 KPSIAAVVGSMDAHPSRYAATVRVQQHRQEIIQELSSMVRELLIMFYKSTGGYKPHRIILYRDGV 796

  Fly   716 GDGQLYTCLNYEIPQFEMVCGNRIK--------ISYIVVQKRINTRIF-------SG-SGIHLEN 764
            .:||....|.:|:......|   ||        |::||||||.:||:|       || ||    |
  Fly   797 SEGQFPHVLQHELTAIREAC---IKLEPEYRPGITFIVVQKRHHTRLFCAEKKEQSGKSG----N 854

  Fly   765 PLPGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYKLCFLYYNWA 829
            ...||.||..||....:||:|.|....|||..|:||.||.||.::..|.:|.|:|:||..|....
  Fly   855 IPAGTTVDVGITHPTEFDFYLCSHQGIQGTSRPSHYHVLWDDNHFDSDELQCLTYQLCHTYVRCT 919

  Fly   830 GTVRIPACCMYAHKLAY 846
            .:|.|||...|||.:|:
  Fly   920 RSVSIPAPAYYAHLVAF 936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	23/168 (14%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	128/492 (26%)
AGO1	NP_725341.1	ArgoN	146..275	CDD:465134	27/144 (19%)
		ArgoL1	285..335	CDD:462567	14/49 (29%)
		PAZ_argonaute_like	336..456	CDD:239212	19/136 (14%)
		Piwi_ago-like	502..942	CDD:240015	121/453 (27%)