Protein Alignment AGO3 and Piwil1

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: XP_017453899.1
• Gene: Piwil1 / 363912
• RGDID: 1306980
• Length: 863
• Species: Rattus norvegicus
• Alignment Length: 866
• Identity: 332/866 - (38%)
• Similarity: 501/866 - (57%)
• Gaps: 76/866 - (8%)

  Fly    58 TLQHVNIS----------------------VGRGRARLIDTLKTDDHTSNQFITSESKENITKKT 100
            |:|||..:                      |||||.|            ...:.:.||....:.:
  Rat    18 TVQHVGAAAQSQQPGYIPPRPQQSPTEGDLVGRGRQR------------GMVVGATSKSQELQIS 70

  Fly   101 KGPESEAIASENG--LFFPDL--------------IYGSKGSSVNIYCNYLKLTTDESKGVFNYE 149
            .|.:..::|...|  ..|.||              ..||.|..|.:..|:.:||:.....::.|.
  Rat    71 AGFQELSLAERGGRRRDFHDLGVNTRQNLDHVKESKTGSSGIIVKLSTNHFRLTSRPQWALYQYH 135

  Fly   150 VRFFPPIDSVHLRIKYLNDHKDKLGGTKTFDGNTLYLPILLPNKMTVFISK---AEDVELQIRIL 211
            :.:.|.:::..||...|..|:|.:|....|||..|:||..|.:|:|...|:   .|.|.:.|.:.
  Rat   136 IDYNPLMEARRLRSALLFQHEDLIGRCHAFDGTILFLPKRLQHKVTEVFSQTRNGEHVRITITLT 200

  Fly   212 YKKKEEMRNCTQLYNILFDRVMKVLNYVKFDRKQFDPSRPKIIPLAKLEVWPGYVTAVDEYKGGL 276
            .:.......|.|.|||:|.|::|::|..:..|..::||.|..||..:|.:|||:.|::.:|:..:
  Rat   201 NELPPTSPTCLQFYNIIFRRLLKIMNLQQIGRNYYNPSDPIDIPNHRLVIWPGFTTSILQYENNI 265

  Fly   277 MLCCDVSHRILCQKTVLEMLVDLYQQNVEH-YQESARKMLVGNIVLTRYNNRTYKINDICFDQNP 340
            |||.||||::|..:|||:.:.:||||..|| :||...|.|:|.||||:|||:||:::||.:||||
  Rat   266 MLCTDVSHKVLRSETVLDFMFNLYQQTEEHKFQEQVSKELIGLIVLTKYNNKTYRVDDIDWDQNP 330

  Fly   341 TCQFEIKTGC-TSYVEYYKQYHNINIKDVNQPLIYSIKKSRGIPAERENLQFCLIPELCYLTGLR 404
            ...|:...|. .|::|||::.:|..|.|:.||::.|..|.|..|.........|||||||||||.
  Rat   331 KSTFKKADGSEVSFLEYYRKQYNQEITDLKQPVLVSQPKRRRGPGGTLPGPAMLIPELCYLTGLT 395

  Fly   405 DEVRSDNKLMREIATFTRVSPNQRQMALNKFYENVSNTPAAQEILNSWGLSLTNNSNKISGRQMD 469
            |::|:|..:|:::|..||::|.|||..:.:..:.:......|..|..||||..:|....|||.:.
  Rat   396 DKMRNDFNVMKDLAVHTRLTPEQRQREVGRLIDYIHKDDNVQRELRDWGLSFDSNLLSFSGRILQ 460

  Fly   470 IEQIYFSKISVSAGRS-------AEFSKHAVTNEMLKVVHLSKWIIIHLRNYRQAATSLLDNMKQ 527
            .|:|:      ..|::       |::||......::.|..|..|::|:.|...:||.||:.|:.:
  Rat   461 SEKIH------QGGKTFDYNPQFADWSKETRGAPLISVKPLDNWLLIYTRRNYEAANSLIQNLFK 519

  Fly   528 ACESLGMNISNPTMISLDHDRIDAYIQALRRNITMNTQMVVCICHNRRDDRYAAIKKICCSEIPI 592
            ...::|:.:....||.:| ||.:||::||::.:|.:||:|||:..:.|.|:|.||||..|::.|.
  Rat   520 VTPAMGIQMKKAIMIEVD-DRTEAYLRALQQKVTSDTQIVVCLLSSNRKDKYDAIKKYLCTDCPT 583

  Fly   593 PSQVINAKTLQNDLKIRSVVQKIVLQMNCKLGGSLWTVKIPFKNVMICGIDSYHDPSNRGNSVAA 657
            |||.:.|:||.....:.::..||.||||||:||.||.|.:|.|..||.|||.|||.:....|:|.
  Rat   584 PSQCVVARTLGKQQTVMAIATKIALQMNCKMGGELWRVDMPLKLAMIVGIDCYHDTTAGRRSIAG 648

  Fly   658 FVASINSSYSQWYSKAVVQTKREEIVNGLSASFEIALKMYRKRNGKLPTNIIIYRDGIGDGQLYT 722
            ||||||...::|:|:.|.|.:.:|:|:||....:.||:.:...|..:|:.:|:||||:|||||.|
  Rat   649 FVASINEGMTRWFSRCVFQDRGQELVDGLKVCLQAALRAWSGCNEYMPSRVIVYRDGVGDGQLKT 713

  Fly   723 CLNYEIPQFEMVC------GNRIKISYIVVQKRINTRIFSGSGIHLENPLPGTVVDQHITKSNMY 781
            .:|||:||| :.|      |...:::.|||:||:|.|.|:.||..|:|||||||:|..:|:...|
  Rat   714 LVNYEVPQF-LDCLKSVGRGYNPRLTVIVVKKRVNARFFAQSGGRLQNPLPGTVIDVEVTRPEWY 777

  Fly   782 DFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYKLCFLYYNWAGTVRIPACCMYAHKLAY 846
            |||:|||.||.|:|:||||.|:.|.....||.||:|:||||.:||||.|.:|:||.|.||||||:
  Rat   778 DFFIVSQAVRSGSVSPTHYNVIYDSSGLKPDHIQRLTYKLCHVYYNWPGVIRVPAPCQYAHKLAF 842

  Fly   847 LIGQSIQRDVAEALSEKLFYL 867
            |:||||.|:...:||.:|:||
  Rat   843 LVGQSIHREPNLSLSNRLYYL 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	62/135 (46%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	189/450 (42%)
Piwil1	XP_017453899.1	GAGE	16..108	CDD:461753	18/101 (18%)
		ArgoL1	230..277	CDD:462567	19/46 (41%)
		PAZ	279..417	CDD:198017	62/137 (45%)
		Piwi_piwi-like_Euk	403..846	CDD:240016	189/450 (42%)