DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AGO3 and aub

DIOPT Version :9

Sequence 1:	NP_001036627.2	Gene:	AGO3 / 3355150	FlyBaseID:	FBgn0250816	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_476734.1	Gene:	aub / 34524	FlyBaseID:	FBgn0000146	Length:	866	Species:	Drosophila melanogaster

Alignment Length:	864	Identity:	272/864 - (31%)
Similarity:	455/864 - (52%)	Gaps:	77/864 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 NISVGRGRARLIDTLKTDDHTSN-------------QFITSESKENIT----KKTKGPESEAIAS 110
            |:...||.|..:.......|:..             |...|..|.:::    .|::|....::..
  Fly    21 NVEANRGFAPSLGQKSDPSHSEGNQASGGNGGGGDAQVGPSIEKSSLSAVQMHKSEGDPRGSVRG 85

  Fly   111 ENGLFFPDLIY----------GSKGSSVNIYCNYLKLTTDESKGVFNYEVRFFPPIDSVHLRIKY 165
            ..  ...||:|          |..|:.:.:..||.|:....:..::.|.|.|.|.:::..||..:
  Fly    86 RR--LITDLVYSRPPGMTSKKGVVGTHITVQANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSF 148

  Fly   166 LNDHKDKLGGTKTFDGNTLYL----------PILLPNKMTVFISKA-EDVELQIRILYKKKEEMR 219
            |.:||..||| ..|||..::.          |.:|.   .|..|:| |::|::|:.:...:....
  Fly   149 LYEHKGILGG-YIFDGTNMFCINQFKAVQDSPYVLE---LVTKSRAGENIEIKIKAVGSVQSTDA 209

  Fly   220 NCTQLYNILFDRVMKVLNYVKFDRKQFDPSRPKIIPLAKLEVWPGYVTAVDEYKGGLMLCCDVSH 284
            ...|:.|::..|.|:.|:.....|..:||.....:...::::||||.|::.:::..::||.::.|
  Fly   210 EQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLENFRMQLWPGYQTSIRQHENDILLCSEICH 274

  Fly   285 RILCQKTVLEMLVDLYQQNVEHYQESARKMLVGNIVLTRYNNRTYKINDICFDQNPTCQFEIKTG 349
            :::..:|:..:|.|..:.: :.||.:.::.::|.::||.|||:||:|:|:.|...|.|:|:...|
  Fly   275 KVMRTETLYNILSDAIRDS-DDYQSTFKRAVMGMVILTDYNNKTYRIDDVDFQSTPLCKFKTNDG 338

  Fly   350 CTSYVEYYKQYHNINIKDVNQPLIYSIKKSRGIPAERENLQFCLIPELCYLTGLRDEVRSDNKLM 414
            ..|||:|||:.:||.|:|:.|||:.|....:.|....:. ...:||||...||:.|.:|:|.:.:
  Fly   339 EISYVDYYKKRYNIIIRDLKQPLVMSRPTDKNIRGGNDQ-AIMIIPELARATGMTDAMRADFRTL 402

  Fly   415 REIATFTRVSPNQRQMALNKFYENVSNTPAAQEILNSWGLSLTNNSNKISGRQMDIEQIYF--SK 477
            |.::..||::|::|...|..|.:.:.:...:.|.|.||.:.|.:...:|..|.:..|:|.|  .|
  Fly   403 RAMSEHTRLNPDRRIERLRMFNKRLKSCKQSVETLKSWNIELDSALVEIPARVLPPEKILFGNQK 467

  Fly   478 ISVSAGRSAEFSKHAVTNEMLKVVHLSKW-IIIHLRNYRQAATSLLDNMKQAC----ESLGMNIS 537
            |.|...| |:::....|..|.|.||:::| :|...||.|:.     ....|.|    .|:.|||.
  Fly   468 IFVCDAR-ADWTNEFRTCSMFKNVHINRWYVITPSRNLRET-----QEFVQMCIRTASSMKMNIC 526

  Fly   538 NPTMISLDHDRIDAYIQALRRNITMNTQMVVCICHNRRDDRYAAIKKICCSEIPIPSQVINAKTL 602
            ||....:..||...|.||:......:.|:|:.:..:..:::|:.|||..|.:.|:||||:..|.:
  Fly   527 NPIYEEIPDDRNGTYSQAIDNAAANDPQIVMVVMRSPNEEKYSCIKKRTCVDRPVPSQVVTLKVI 591

  Fly   603 ----QNDLKIRSVVQKIVLQMNCKLGGSLWTVKIPFKNVMICGIDSYHDPSNRGNSVAAFVASIN 663
                |....:.|:..|:|:|||.||.|:.|.|.||...:|..|.|..|.|.|:..|..||||:::
  Fly   592 APRQQKPTGLMSIATKVVIQMNAKLMGAPWQVVIPLHGLMTVGFDVCHSPKNKNKSYGAFVATMD 656

  Fly   664 SSYS-QWYSKAVVQTKREEIVNGLSASFEIALKMYRKRNGKLPTNIIIYRDGIGDGQLYTCLNYE 727
            ...| :::|......|.:|:...:|.:...||:.|::::..||..|:.:|||:||||||..:|.|
  Fly   657 QKESFRYFSTVNEHIKGQELSEQMSVNMACALRSYQEQHRSLPERILFFRDGVGDGQLYQVVNSE 721

  Fly   728 I-------PQFEMVCGNR--IKISYIVVQKRINTRIFSGSGIHLENPLPGTVVDQHITKSNMYDF 783
            :       .:.....|.:  .::::|:|.||||:|.|:|.    .||:||||||..||....|||
  Fly   722 VNTLKDRLDEIYKSAGKQEGCRMTFIIVSKRINSRYFTGH----RNPVPGTVVDDVITLPERYDF 782

  Fly   784 FLVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYKLCFLYYNWAGTVRIPACCMYAHKLAYLI 848
            |||||.||.|||:||.|.|:.|:.....|.:|.||||:..:|||::||:|:||.|.||||||:|:
  Fly   783 FLVSQAVRIGTVSPTSYNVISDNMGLNADKLQMLSYKMTHMYYNYSGTIRVPAVCHYAHKLAFLV 847

  Fly   849 GQSIQRDVAEALSEKLFYL 867
            .:||.|..:..|..:|::|
  Fly   848 AESINRAPSAGLQNQLYFL 866

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	47/133 (35%)
AGO3	NP_001036627.2	Piwi_piwi-like_Euk	412..850	CDD:240016	165/458 (36%)
aub	NP_476734.1	ArgoN	105..219	CDD:293095	30/117 (26%)
		PAZ_piwi_like	272..392	CDD:239211	42/121 (35%)
		Piwi_piwi-like_Euk	400..849	CDD:240016	165/458 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449120
Domainoid	1	1.000	84	1.000	Domainoid score	I5262
eggNOG	1	0.900	-	-		E1_KOG1042
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	1	1.000	-	-		FOG0003636
OrthoInspector	1	1.000	-	-		otm14694
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	1	1.100	-	-	P	PTHR22891
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3665
SonicParanoid	1	1.000	-	-		X548
	11	10.780