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Protein Alignment AGO3 and Ago2

DIOPT Version :10

Sequence 1:	NP_001036627.2	Gene:	AGO3 / 3355150	FlyBaseID:	FBgn0250816	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_694818.3	Gene:	Ago2 / 239528	MGIID:	2446632	Length:	860	Species:	Mus musculus

Alignment Length:	847	Identity:	200/847 - (23%)
Similarity:	349/847 - (41%)	Gaps:	181/847 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 PDLIYGSKGSSVNIYCNYLKLTTDESK-GVFNYEVRFFPP----------IDSV--HLRIKYLND 168
            ||  :|:.|.::.:..|:.::  |..| .:::||:...|.          ::.:  |.:.:...|
Mouse    30 PD--FGTTGRTIKLQANFFEM--DIPKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGD 90

  Fly   169 HKDKLGGTKTFDG-NTLYLPILLPNKMTVFISKAEDVELQIRI-------LYKKKEEMRNCTQ-- 223
            .|      ..||| ..||..:.||      |.: :.|||::.:       ::|...:..:|..
Mouse    91 RK------PVFDGRKNLYTAMPLP------IGR-DKVELEVTLPGEGKDRIFKVSIKWVSCVSLQ 142

  Fly   224 -LYNILFDRVMKV-----------------LNYVKFDRKQFDPSRPKIIPL-AKLEVWPGY---- 265
             |::.|..|:..|                 :.|....|..|..|.....|| ...|||.|:
Mouse   143 ALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPVGRSFFTASEGCSNPLGGGREVWFGFHQSV 207

  Fly   266 ------------VTAVDEYKGG--LMLCCDV---------------SHRILCQKTVLEMLVDLYQ 301
                        |:|...||..  :...|:|               |.|:...|.:..:.|:
Mouse   208 RPSLWKMMLNIDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVE--- 269

  Fly   302 QNVEHYQESARKMLVGNIVLTRYNNRTYKINDICFDQNPTCQFEIKTGCTSYVEYYKQYHNINIK 366
              :.|..:..||..|.|:.....:::|:.:..   :...|.:      || ..:|:|..|.:.::
Mouse   270 --ITHCGQMKRKYRVCNVTRRPASHQTFPLQQ---ESGQTVE------CT-VAQYFKDRHKLVLR 322

  Fly   367 DVNQPLIY--SIKKSRGIPAERENL---QFCLIPELCYLTGLRDEVRSDNKLMREIATFTRVSPN 426
            ..:.|.:.  ..:|...:|.|..|:   |.|:            :..:||:....|....|.:|:
Mouse   323 YPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCI------------KKLTDNQTSTMIRATARSAPD 375

  Fly   427 QRQMALNKFYENVS-NT-PAAQEILNSWGLSLTNNSNKISGRQMDIEQIYFSKISVSAGRSAEFS 489
             ||..::|...:.| || |..:|    :|:.:.:....::||.:....|.:      .||:...:
Mouse   376 -RQEEISKLMRSASFNTDPYVRE----FGIMVKDEMTDVTGRVLQPPSILY------GGRNKAIA 429

  Fly   490 KHA-----VTNEMLKV-VHLSKWIIIHLRNYRQAA----TSLLDNMKQACESLGMNISNPTMI-- 542
            ...     :.|:.... :.:..|.|......||..    .|..:.:::.....||.|......
Mouse   430 TPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQPCFCK 494

  Fly   543 -SLDHDRIDAYIQALRRNITMNTQMVVCICHNRRDDRYAAIKKICCSEIPIPSQVINAKTLQNDL 606
             :...|.::...:.| :|.....|:||.|... :...||.:|::..:.:.:.:|.:..|.:|...
Mouse   495 YAQGADSVEPMFRHL-KNTYAGLQLVVVILPG-KTPVYAEVKRVGDTVLGMATQCVQMKNVQRTT 557

  Fly   607 KIRSVVQKIVLQMNCKLGGSLWTVKIP------FKN-VMICGIDSYHDPSNRGN--SVAAFVASI 662
            .  ..:..:.|::|.|||| :..:.:|      |:. |:..|.|..|.|:..|.  |:||.|.|:
Mouse   558 P--QTLSNLCLKINVKLGG-VNNILLPQGRPPVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSM 619

  Fly   663 NSSYSQWYSKAVVQTKREEIVNGLSASF-EIALKMYRKRNGKLPTNIIIYRDGIGDGQLYTCLNY 726
            ::..:::.:...||..|:||:..|:|.. |:.::.|:....| ||.||.||||:.:||....|::
Mouse   620 DAHPNRYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFK-PTRIIFYRDGVSEGQFQQVLHH 683

  Fly   727 EIPQFEMVCGNRIK--------ISYIVVQKRINTRIF---SGSGIHLENPLP-GTVVDQHITKSN 779
            |:......|   ||        |::||||||.:||:|   ....:.....:| ||.||..||...
Mouse   684 ELLAIREAC---IKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDTKITHPT 745

  Fly   780 MYDFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYKLCFLYYNWAGTVRIPACCMYAHKL 844
            .:||:|.|....|||..|:||.||.||..:..|.:|.|:|:||..|.....:|.|||...|||.:
Mouse   746 EFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLV 810

  Fly   845 AY 846
            |:
Mouse   811 AF 812

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.