Protein Alignment AGO3 and Ago1

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_001304102.1
• Gene: Ago1 / 236511
• MGIID: 2446630
• Length: 895
• Species: Mus musculus
• Alignment Length: 905
• Identity: 214/905 - (23%)
• Similarity: 370/905 - (40%)
• Gaps: 210/905 - (23%)

  Fly   102 GPESEAIASENGLFFPDL--IY--------GSKGSSVNIYCNYLKLTTDESK-GVFNYEVRFFPP 155
            ||...|.    |.:.|.|  ::        |:.|..:.:..||.::  |..| .|::|||...|
Mouse     4 GPSGAAA----GAYLPPLQQVFQAPRRPGIGTVGKPIKLLANYFEV--DIPKIDVYHYEVDIKP- 61

  Fly   156 IDSVHLR-----IKYLNDH-KDKLGGTK--TFDG-NTLYLPILLPNKMTVFISKAEDVELQIRIL 211
             |....|     ::|:..| |.::.|.:  .:|| ..:|....||      |.. |.|:.::.|.
Mouse    62 -DKCPRRVNREVVEYMVQHFKPQIFGDRKPVYDGKKNIYTVTALP------IGN-ERVDFEVTIP 118

  Fly   212 YKKKEEMRNCT----------QLYNILFD-----------------RVMKVLNYVKFDRKQFDPS 249
            .:.|:.:...:          .|:..|..                 |.:..:.|....|..|.|.
Mouse   119 GEGKDRIFKVSIKWLAIVSWRMLHEALVSGQIPVPLESVQALDVAMRHLASMRYTPVGRSFFSPP 183

  Fly   250 RPKIIPL-AKLEVWPGYVTAVDEYKGGLMLCCDVSHRILCQ-KTVLEMLVDLYQ-QNVE------ 305
            .....|| ...|||.|:..:|......:||..|||.....: :.|:|.:.::.. :|::
Mouse   184 EGYYHPLGGGREVWFGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIEFMCEVLDIRNIDEQPKPL 248

  Fly   306 --------------------HYQESARKMLVGNIVLTRYNNRTYKINDICFDQNPTCQFEIKTG- 349
                                |..:..||..|.|:.....:::|:.:             ::::|
Mouse   249 TDSQRVRFTKEIKGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPL-------------QLESGQ 300

  Fly   350 ---CTSYVEYYKQYHNINIKDVNQPLIY--SIKKSRGIPAERENL---QFCLIPELCYLTGLRDE 406
               || ..:|:||.:|:.:|..:.|.:.  ..:|...:|.|..|:   |.|:            :
Mouse   301 TVECT-VAQYFKQKYNLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAGQRCI------------K 352

  Fly   407 VRSDNKLMREIATFTRVSPNQRQMALNKFYENVSNT--PAAQEILNSWGLSLTNNSNKISGRQMD 469
            ..:||:....|....|.:|: ||..:::..:|.|..  |..||    :|:.:.::..:::||.:.
Mouse   353 KLTDNQTSTMIKATARSAPD-RQEEISRLMKNASYNLDPYIQE----FGIKVKDDMTEVTGRVLP 412

  Fly   470 IEQIYFSKISVSAGRSAEFSKHAVTN---------EMLKVVHLSKWIIIHLRNYRQAATSLL--- 522
            ...:.:      .||:...   |..|         :....:.:..|.|......:|....:|
Mouse   413 APILQY------GGRNRAI---ATPNQGVWDMRGKQFYNGIEIKVWAIACFAPQKQCREEVLKNF 468

  Fly   523 -DNMKQACESLGMNISNPTMI---SLDHDRIDAYIQALRRNITMNTQMVVCICHNRRDDRYAAIK 583
             |.:::..:..||.|......   :...|.::...:.| :|.....|:::.|... :...||.:|
Mouse   469 TDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHL-KNTYSGLQLIIVILPG-KTPVYAEVK 531

  Fly   584 KICCSEIPIPSQVINAKTLQNDLKIR-SVVQKIVLQMNCKLGGSLWTVKIPFKN-------VMIC 640
            ::..:.:.:.:|.:..|   |.:|.. ..:..:.|::|.|||| :..:.:|.:.       |:..
Mouse   532 RVGDTLLGMATQCVQVK---NVVKTSPQTLSNLCLKINVKLGG-INNILVPHQRSAVFQQPVIFL 592

  Fly   641 GIDSYHDPSNRGN--SVAAFVASINSSYSQWYSKAVVQTKREEIVNGLSASF-EIALKMYRKRNG 702
            |.|..|.|:..|.  |:.|.|.|:::..|::.:...||..|:||:..||... |:.::.|:....
Mouse   593 GADVTHPPAGDGKKPSITAVVGSMDAHPSRYCATVRVQRPRQEIIEDLSYMVRELLIQFYKSTRF 657

  Fly   703 KLPTNIIIYRDGIGDGQLYTCLNYEIPQFEMVCGNRIK--------ISYIVVQKRINTRIF---S 756
            | ||.||.||||:.:|||...|:||:......|   ||        |:|||||||.:||:|   .
Mouse   658 K-PTRIIFYRDGVPEGQLPQILHYELLAIRDAC---IKLEKDYQPGITYIVVQKRHHTRLFCADK 718

  Fly   757 GSGIHLENPLP-GTVVDQHITKSNMYDFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYK 820
            ...|.....:| ||.||.:||....:||:|.|....|||..|:||.||.||..:..|.:|.|:|:
Mouse   719 NERIGKSGNIPAGTTVDTNITHPFEFDFYLCSHAGIQGTSRPSHYYVLWDDNRFTADELQILTYQ 783

  Fly   821 LCFLYYNWAGTVRIPACCMYAHKLAY------------------LIGQSIQRDVAEALSE 862
            ||..|.....:|.|||...||..:|:                  :.|||..|| .:||::
Mouse   784 LCHTYVRCTRSVSIPAPAYYARLVAFRARYHLVDKEHDSGEGSHISGQSNGRD-PQALAK 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	28/169 (17%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	129/496 (26%)
Ago1	NP_001304102.1	ArgoN	34..164	CDD:465134	27/140 (19%)
		ArgoL1	174..224	CDD:462567	15/49 (31%)
		PAZ_argonaute_like	225..345	CDD:239212	22/133 (17%)
		Piwi_ago-like	390..815	CDD:240015	122/447 (27%)