Protein Alignment AGO3 and alg-1

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_001367206.1
• Gene: alg-1 / 181504
• WormBaseID: WBGene00000105
• Length: 1023
• Species: Caenorhabditis elegans
• Alignment Length: 871
• Identity: 202/871 - (23%)
• Similarity: 359/871 - (41%)
• Gaps: 180/871 - (20%)

  Fly   110 SENGLFF-----PDLIYGSKGSSVNIYCNYLKLTTDESKGVFNYEVRFFPPIDSVHLRI------ 163
            :::|:.|     |:  :|.:|.|:.:..|:..:...... :.:|:|...|  |....|:
 Worm   151 NQSGIQFQCPRRPN--HGVEGRSILLRANHFAVRIPGGT-IQHYQVDVTP--DKCPRRVNREIIS 210

  Fly   164 -------KYLNDHKDKLGGTKTFDG-NTLYLPILLP---NKMTVFISKAED--VELQIRILYKKK 215
                   ||..:.:      ..:|| ..:|....||   .:|...::...|  ||.|..:..|..
 Worm   211 CLISAFSKYFTNIR------PVYDGKRNMYTREPLPIGRERMDFDVTLPGDSAVERQFSVSLKWV 269

  Fly   216 EEMRNCTQLYNILFDRVMKV-----------------LNYVKFDRKQFDPSRPKIIPL------- 256
            .:: :.:.|.:.:..||.:|                 |.|....|..|.|..|....:
 Worm   270 GQV-SLSTLEDAMEGRVRQVPFEAVQAMDVILRHLPSLKYTPVGRSFFSPPVPNASGVMAGSCPP 333

  Fly   257 -------------------AKL----EVWPGYVTAVDEYKGGLMLCCDVSHRILCQK-TVLEMLV 297
                               :||    |||.|:..:|...:..:||..|||.....:. .|:|.:.
 Worm   334 QASGAVAGGAHSAGQYHAESKLGGGREVWFGFHQSVRPSQWKMMLNIDVSATAFYRSMPVIEFIA 398

  Fly   298 DLYQQNVEHYQESARKMLVGNIVLTR-------------YNNRTYKINDICF--DQNPTCQFEIK 347
            ::.:..|:...|.........:..|:             ...|.|::.::..  .|..|...:::
 Worm   399 EVLELPVQALAERRALSDAQRVKFTKEIRGLKIEITHCGQMRRKYRVCNVTRRPAQTQTFPLQLE 463

  Fly   348 TG----CTSYVEYYKQYHNINIKDVNQPLIY--SIKKSRGIPAERENL---QFCL--IPELCYLT 401
            ||    ||....:|.:| .|.:|..:.|.:.  ..:|...:|.|..|:   |.|:  :.::...|
 Worm   464 TGQTIECTVAKYFYDKY-RIQLKYPHLPCLQVGQEQKHTYLPPEVCNIVPGQRCIKKLTDVQTST 527

  Fly   402 GLRDEVRSDNKLMREIATFTRVSPNQRQMALNKFYENVSNTPAAQEILNSWGLSLTNNSNKISGR 466
            .::...||..:..|||:...|.:             ..|..|.|.|    :|:::.....::.||
 Worm   528 MIKATARSAPEREREISNLVRKA-------------EFSADPFAHE----FGITINPAMTEVKGR 575

  Fly   467 QMDIEQIYFSKISVSAGRSAEFSKHAVTNEMLKVVH----LSKWIIIHLRNYRQAATSLL----D 523
            .:...::.:.    ...|:.......|.:...|..|    :..|.|......:....:.|    :
 Worm   576 VLSAPKLLYG----GRTRATALPNQGVWDMRGKQFHTGIDVRVWAIACFAQQQHVKENDLRMFTN 636

  Fly   524 NMKQACESLGMNI-SNPTM--ISLDHDRIDAYIQALRRNITMNTQMVVCICHNRRDDRYAAIKKI 585
            .:::.....||.| .||..  .::..::::...:.|::|.: ..|:||.:... :...||.:|::
 Worm   637 QLQRISNDAGMPIVGNPCFCKYAVGVEQVEPMFKYLKQNYS-GIQLVVVVLPG-KTPVYAEVKRV 699

  Fly   586 CCSEIPIPSQVINAKTLQNDLKIRSVVQ---KIVLQMNCKLGGSLWTVKIP------FKN-VMIC 640
            ..:.:.|.:|.:.||.     .||:..|   .:.|:||.|||| :.::.:|      |.. |:..
 Worm   700 GDTVLGIATQCVQAKN-----AIRTTPQTLSNLCLKMNVKLGG-VNSILLPNVRPRIFNEPVIFF 758

  Fly   641 GIDSYHDPS--NRGNSVAAFVASINSSYSQWYSKAVVQTKREEIVNGLSASF-EIALKMYRKRNG 702
            |.|..|.|:  :|..|:||.|.|:::..|::.:...||..|:||::.|:... |:.::.||....
 Worm   759 GCDITHPPAGDSRKPSIAAVVGSMDAHPSRYAATVRVQQHRQEIISDLTYMVRELLVQFYRNTRF 823

  Fly   703 KLPTNIIIYRDGIGDGQLYTCLNYEIPQFEMVC-----GNRIKISYIVVQKRINTRIFS------ 756
            | |..|::||||:.:||.:..|.||:......|     |.:..|::|.||||.:||:|:
 Worm   824 K-PARIVVYRDGVSEGQFFNVLQYELRAIREACMMLERGYQPGITFIAVQKRHHTRLFAVDKKDQ 887

  Fly   757 -GSGIHLENPLPGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYK 820
             |...::.   |||.||..||....:||:|.|....|||..|:||.||.||.|...|.:|:|:|:
 Worm   888 VGKAYNIP---PGTTVDVGITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNNLTADELQQLTYQ 949

  Fly   821 LCFLYYNWAGTVRIPACCMYAHKLAY 846
            :|..|.....:|.|||...|||.:|:
 Worm   950 MCHTYVRCTRSVSIPAPAYYAHLVAF 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	31/159 (19%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	128/471 (27%)
alg-1	NP_001367206.1	ArgoN	170..300	CDD:465134	24/139 (17%)
		ArgoL1	310..389	CDD:462567	16/78 (21%)
		PAZ_argonaute_like	390..511	CDD:239212	22/121 (18%)
		Piwi_ago-like	556..981	CDD:240015	123/440 (28%)