Protein Alignment AGO3 and sago-1

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_504610.1
• Gene: sago-1 / 179016
• WormBaseID: WBGene00019666
• Length: 881
• Species: Caenorhabditis elegans
• Alignment Length: 951
• Identity: 187/951 - (19%)
• Similarity: 339/951 - (35%)
• Gaps: 258/951 - (27%)

  Fly    95 NITKKTKGPESEAIASENGLFF---------PDLIYGSKGSSVNIYCNYLKLTTDESKGVFNYEV 150
            |||:.|....|.:::::..|..         |..: ..:|:.|.|..|..|:..:::..:|.|
 Worm     3 NITQVTSSMASASLSNKAPLPVGHQPLAEKKPKEV-NQEGTPVQIVTNMRKINLEKNHSIFKY-- 64

  Fly   151 RFFPPIDSVHLRIKYLNDHKDKLGGTKTFDGNTLYLPILLPNKMTVFISKAEDVELQIRILYKKK 215
                   ||.:...|     .|..||:           |:..|.....|..:....:...|...:
 Worm    65 -------SVQVLFVY-----QKSDGTE-----------LVLEKSKSVGSGCDHERSKSHCLRVYR 106

  Fly   216 EEMRNCTQLYN---ILFDRVMKVLNYVKFDRKQFD--------PSRPKII----PLAKLEVWPGY 265
            :..:.|.:|.:   ..:|....:.::.|....:|.        .:.||.:    .|||::  ..:
 Worm   107 KAAKQCQELKSGGPFCYDSQGCLYSFSKLKNDEFSTNITGSDISNNPKFLRVEFKLAKVQ--ESF 169

  Fly   266 VTAVDEYKGGLMLCCDVSHRILC-----QKTVLEMLVDLYQ-QNVEHYQESARKMLVGNIVLTRY 324
            .|..:          ||:..:.|     :||:||.:..:.. ..:.|    ...:.:||.|...|
 Worm   170 QTTTN----------DVAKSVNCRPALQEKTILEAMNQIVSTAPINH----PNVLTIGNCVHYLY 220

  Fly   325 NNRTYKINDICFDQNPT-------------------CQF---EIKT------GCTSYVEYYKQYH 361
            ::....|..|..:...:                   |.:   |:||      .| |.::.:..|.
 Worm   221 DDTNIDIRSITGEGGKSSAVGASKSVRTLEGTGKTPCLYMATELKTTLFHPDNC-SLLKVFMDYR 284

  Fly   362 NIN--IKDVNQPLIYSIK---------------------------KSRGIPA-----ERENLQFC 392
            ..|  :| .|.|.:...|                           |..|:.|     ||:|.:..
 Worm   285 GFNGSLK-ANSPFVLKNKNAFIGLWCYTTHGKCSDWKDDRPMIKIKDFGLSAKETTFERDNKKIS 348

  Fly   393 L-------------------------------IPELCYLTGLRDEVRSDNKLMREIATFTRVS-- 424
            :                               ||..|........||::..:..|.|...:::
 Worm   349 VFNYFQVKYNMTLKYPDLFTVVARGKDGKNQHIPVECLDLCNSQTVRTEQMVGTEQADLIKLAAA 413

  Fly   425 -PNQRQMALNKFYENVSNTPAAQEILNSWGLS-------LTNNSNKISGRQMDIEQIYFS---KI 478
             |:.|        :.:::|     ::||.||:       .......::|..:....||||   |:
 Worm   414 KPHDR--------KKITDT-----VVNSIGLASEPKGIISVGAPESVTGLVLPKPDIYFSGGKKV 465

  Fly   479 ----SVSAGRSAEFSKHAVTNEMLKVVHLSKWIIIHLRNYRQAATSLLD---NMKQACESLGMNI 536
                ....|.:.:|..   ....:|...|:.|.::.     .....|:|   ::......|||.:
 Worm   466 FWNDPKKRGPATDFMP---AGTFIKPTKLTNWEVVF-----DNGVQLVDCIQHLTSTMRQLGMEV 522

  Fly   537 SNPTMISLDHDRIDAYIQALRRNI-TMNTQMVVCICHNRRDDRYAAIKKICCSEIPIPSQVINAK 600
            ||||:..::.    .|::::..|. ..|.|:::.|  .:..:.|....|....|..:.:|.|..:
 Worm   523 SNPTVSLINR----GYLRSIFENAKAANRQLIMFI--TKSMNNYHTEIKCLEQEFDLLTQDIRFE 581

  Fly   601 TLQNDLKIRSVVQKIVLQMNCKLGGSLWTVKI-PFKNV--MICGIDSYHDPSNRGN----SVAAF 658
            |.....:.::..:.|:.:.|.||||..:.::. .|.|.  :|.|.::    |.||.    .:|..
 Worm   582 TAVKLAQQQNTRKNIIYKTNMKLGGLNYELRSGVFSNSKRLIIGFET----SQRGGLGDAPIAIG 642

  Fly   659 VASINSSYSQWYSKAVVQTKREEIVNGLSASFEIALKMYRK----RNGKLPTNIIIYRDGIGDGQ 719
            .|:...|:||.::...:..|:.....| ....||.|.:.::    |....|..::||..|:.:||
 Worm   643 FAANMMSHSQQFAGGYMFVKKSADNYG-PVIPEILLTILKQAKANRPNDRPDELLIYFSGVSEGQ 706

  Fly   720 LYTCLNYEIPQFEMVCG-----NRIKISYIVVQKRINTRIF---SGSGIHLENPLPGTVVDQHIT 776
            ......|...|.:..||     .|..|:.|:..|..|||::   :|.|:.  |..||||:|..|.
 Worm   707 HALVNEYYANQVKAACGLFNESFRPHITLILASKVHNTRVYKSENGGGVC--NVEPGTVIDHTIV 769

  Fly   777 KSNMYDFFLVSQLVRQGTVTPTHY-VVLRDDCNYGPDIIQKLSYKLCF------------LYYNW 828
            ...:.:::....|.||||.....| ::.....|....:.::|:.:||:            :..:.
 Worm   770 SPVLSEWYHAGSLARQGTSKLVKYSLIFNTKKNEKLSVYERLTNELCYEMQIVFHPTSLPIPLHI 834

  Fly   829 AGTVRIPACCMYA-HKLAYLIGQSIQRDVAEAL---SEKLF 865
            |||.......|.| .|..|..|:..|....|.|   |:|||
 Worm   835 AGTYSERGSQMLALKKPIYTNGEFNQVATNEQLGYASKKLF 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	35/230 (15%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	107/491 (22%)
sago-1	NP_504610.1	PAZ	281..412	CDD:198017	19/131 (15%)
		Piwi-like	443..844	CDD:239208	94/421 (22%)