Protein Alignment AGO3 and ergo-1

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_503362.2
• Gene: ergo-1 / 178602
• WormBaseID: WBGene00019971
• Length: 1121
• Species: Caenorhabditis elegans
• Alignment Length: 1085
• Identity: 211/1085 - (19%)
• Similarity: 371/1085 - (34%)
• Gaps: 377/1085 - (34%)

  Fly     9 SLFNKNAGNMGKSISSKDHEIDSGLDFNNSESSGERLLSSHNIETDLITTLQHVNISVGRGRARL 73
            :::::|.||.|.               ......|.|..:..:...||:........||.:...|
 Worm   118 NMYSQNGGNRGG---------------GGGRVGGGRTAAGMSNPGDLVGGADQPIHSVSKKSLR- 166

  Fly    74 IDTLKTDDHTSNQFITSESKENITKKTKGPESEAIASENGLFFPDLIYGSKGSSVNIYCNYLKLT 138
                    |.:.:|.       :..||       :..:.||          |....:..|:..:.
 Worm   167 --------HNAQEFA-------VRPKT-------MVQDKGL----------GQKTTLLTNHTLVQ 199

  Fly   139 TDE---SKGVFNYEVRFFPPIDSVHLRIKYLN---DHKDKLGGTKTFDGNTLYLPILLPNKMT-- 195
            ..:   :..|||.||              ::|   .:|.:|.|.:.::       ||..||.|
 Worm   200 LPQEPITLHVFNIEV--------------FINGKSSNKRELCGPRFWE-------ILKENKPTFG 243

  Fly   196 -----VFISKAEDVEL-----------------QIRILYKKKEEMR--------NCTQLYNILFD 230
                 :|    .||.:                 ::..::|..::::        ...||.:.|.|
 Worm   244 MPNQYIF----NDVNMMWSTNKLRQSEGRTNNRRMNFVWKYVKQIKFGGNIEDEETMQLLSTLID 304

  Fly   231 ----------------RVMKVLNYVKFDRKQFDPSRPKIIPLAKLEVWP----GYVTAV-DEYKG 274
                            .|.|.|.|: ...:.::|..|.:....||.:..    |...|: ...:.
 Worm   305 AIATQRARLPLAPPKYTVFKRLTYL-ICEEAYEPELPDVSLCHKLRIGTDARVGVSIAIRTNLRA 368

  Fly   275 GLMLCCDVSH-----------RILC----QKTVLEMLVDL-YQQNVEHYQESARKMLVGNIVLTR 323
            |:..|.|:.|           |:||    ...||:...:: |...:.....|...:.|...:||:
 Worm   369 GITACFDLGHTLFTRPAYPLVRLLCDIIEHSVVLDEAFEMKYDAALRACNVSDENLRVMTQILTK 433

  Fly   324 YNNRTYKINDICFD----------------QNPTCQFE-IKTGC-------------TSYVEYYK 358
               .|.:::....|                :||...|: :..|.             .:..:||.
 Worm   434 ---MTLQLSTETGDYVGEDGEVIVRPAPTIRNPGRNFKFVGLGAPADRYYFTSDGVELTVADYYL 495

  Fly   359 QYHNINIKDVNQPLIYSIKKSRGIPAERENLQFCLIPELCYLTGLRDEVRSDNK-------LMRE 416
            |.:||.::..|.|.:  :||:               ||.|           .||       |:..
 Worm   496 QKYNIRLRYPNLPCV--LKKA---------------PEQC-----------GNKHSAMPLELVSY 532

  Fly   417 IATFTR----VSPNQRQMALNK-FYENVSNTPAAQEILNSWGLS-----LTNNSNKISGRQMDIE 471
            |...||    ..|:.|...:|| .|.........|.|:....||     ::||.:.:...::.::
 Worm   533 IVVPTRYGGFTMPDMRADMINKTTYTAQQRGKLLQHIIAQKSLSGIEPPVSNNDDYMKKHKLVMK 597

  Fly   472 QIYFSKISVSA----------GRSAEFSKHAVTNEMLKVVHLSKW--------------IIIHLR 512
            :   ..|.|.|          |.|....:|          |:.:|              .:...:
 Worm   598 R---EPIRVKATILPPPTLVYGDSVFHDEH----------HIGEWEAVTHDPPRQVLDGAVFRRK 649

  Fly   513 NYRQAATSLLDNM---------KQACESLGMN------------ISNPTMISLDHDR-------- 548
            .|:.:...|:..:         .:.|.....|            .|...::..|.::
 Worm   650 LYKSSEQPLMKRLMGSILLIQSPRQCRDFDYNQQGYHAIMRAIEDSGQPVLWADENKHSAVIQGE 714

  Fly   549 ------------IDAYIQALRRNI---TMNTQMVVCIC-------------HNRRDDRYAAIKKI 585
                        |:.::|.::..|   ..:.:::|.|.             :|...:.|..:|.:
 Worm   715 LQFNQNQHGIEVIEQFLQNIKSTIGEYERDGEVIVPIVFAVFQARATVYSGNNNEYNDYNVLKYL 779

  Fly   586 CCSEIPIPSQVINAKTL-------QNDLKIRSVVQKIVLQMNC---KL--GGS--LWTV-KIPFK 635
            ..::..|.:|.|..|:|       :|....|.:|:|::.::..   ||  ||:  .||: ..|.|
 Worm   780 ADNKYGIHTQGILEKSLGVVGPSPKNCALTRLMVEKVLGKVGTTHRKLERGGAHKTWTIFTDPAK 844

  Fly   636 NVMICGIDSYHDPSNR----GN-----SVAAFVASINSSYSQWYSKAVVQTKREEIVNGLSASFE 691
            ..::.|||..| ||.|    ||     |.|..|.:|:...:::.:.:.:|....|.:...|...:
 Worm   845 PTLVLGIDVSH-PSTRDRETGNVLQKMSAATVVGNIDLDVTEFRASSRIQDTGVECLIDFSKEID 908

  Fly   692 IALKMYRKRNGKLPTNIIIYRDGIGDGQLYTCLNYEIPQFEMVC-----GNRIKISYIVVQKRIN 751
            ..:..:....||.|.:|::||||:.:|.....|..|....|..|     ..:..|:||||.||.:
 Worm   909 ERIGEFIDHTGKRPAHIVVYRDGLSEGDFQKYLFEERVCIEERCLKIDTSFQPSITYIVVTKRHH 973

  Fly   752 TRIFSGSGIHLENP-----------LPGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTHYVVLRD 805
            |:.|      ||:|           ||||:::..:|.:..|||||.:|:..:|...||||.||.|
 Worm   974 TQFF------LEDPSQGYESQGYNVLPGTLIEDAVTTNKYYDFFLSTQIGNEGCFRPTHYYVLHD 1032

  Fly   806 DC-----NYGPDIIQKLSYKLCFLYYNWAGTVRIPACCMYAHKLA 845
            ..     ::.|.:...|:|..|    ....||.:||..:|||..|
 Worm  1033 TWTGKPDSFWPTVTHALTYNFC----RSTTTVALPAPVLYAHLAA 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	31/175 (18%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	127/577 (22%)
ergo-1	NP_503362.2	PAZ	421..557	CDD:198017	31/166 (19%)
		Piwi_ago-like	588..1080	CDD:240015	111/510 (22%)