Protein Alignment AGO3 and alg-3

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_502217.1
• Gene: alg-3 / 178106
• WormBaseID: WBGene00011910
• Length: 1035
• Species: Caenorhabditis elegans
• Alignment Length: 896
• Identity: 206/896 - (22%)
• Similarity: 309/896 - (34%)
• Gaps: 257/896 - (28%)

  Fly   136 KLTTDESKGVFNYEVRFFPPI---------DSVH-----LRIKYLNDH------------KDKLG 174
            ||..||.:.:|...|...|.|         |..|     .|:::.:|.            ||...
 Worm   129 KLDKDEMRIIFWKAVSDHPNIFHNKFALAYDGAHQLYTVARLEFPDDQGSVRLDCEATLPKDNRD 193

  Fly   175 GTKTFDGNTLYLPILLPNKMTVFISKAEDVELQIRILYKKKEEMRNCTQLYNILFDRVMKVLNYV 239
            .|:.........|:||..:.|...:..|.|...|:||.....:...|..|.|        ..|:.
 Worm   194 RTRCAISIQNVGPVLLEMQRTRTNNLDERVLTPIQILDIICRQSLTCPLLKN--------SANFY 250

  Fly   240 KFDRKQFDPSRPKIIPLAK---------LEVWPGYVTA---VDEYKGGLMLCCDVSHRILCQK-- 290
            .:....:.      ||.|.         .|:|.|:.::   ...|:.  :|..||:|....:.
 Worm   251 TWKSSCYR------IPTAAGQALDLEGGKEMWTGFFSSAHIASNYRP--LLNIDVAHTAFYKTRI 307

  Fly   291 TVLEMLVDLYQQNVE--------------------------HYQE---------SARKMLVGN-- 318
            |||:.:.|:..:...                          .||.         :.|....||
 Worm   308 TVLQFMCDVLNERTSKPNRNNPRGPGAPGGYRGGRGGARGGSYQNFGNRGPPGANVRDDFGGNGL 372

  Fly   319 -----------------------------IVLTRYNN--RTYKINDICFDQNPTCQF-------E 345
                                         |..|...|  |.||:|.:   |.|..:.       |
 Worm   373 TFTMDTLSRDTQLSSFETRIFGDSIRGMKIRATHRPNAIRVYKVNSL---QLPADKLMFQGIDEE 434

  Fly   346 IKTGCTSYVEYYKQYHNINIKDVNQPLIYSIKKSRGI--PAERENLQFCLIPELCYLTGLRDEVR 408
            .:....|..:|:.:.:. .:|....|.::....:|.|  |.|.     |||          |..:
 Worm   435 GRQVVCSVADYFSEKYG-PLKYPKLPCLHVGPPTRNIFLPMEH-----CLI----------DSPQ 483

  Fly   409 SDNKLMRE-----IATFTRVSPNQRQMALNKFYENVSNTPAAQEILNSWGLSLTNNSNKISGRQM 468
            ..||.|.|     |.....|...||:..:.:.....|.  .....|..:|:::::...:.|.|.:
 Worm   484 KYNKKMTEKQTSAIIKAAAVDATQREDRIKQLAAQASF--GTDPFLKEFGVAVSSQMIETSARVI 546

  Fly   469 DIEQIYFSKISVSAGRSAEFSKHAVTNEMLKVVHLSK---WIIIHLRNYRQAA------TSLLD- 523
            ....|.|..                .|..:..|...|   |.:.|...|..|.      .:|:|
 Worm   547 QPPPIMFGG----------------NNRSINPVVFPKDGSWSMDHQTLYMPATCRSYSMIALVDP 595

  Fly   524 ----NMKQACESL-------GMNISN-PTMISLDHDRIDAYIQALRRNITMNTQM--------VV 568
                :::..|:||       |||... |.::.....:.|.        .|:.|::        .|
 Worm   596 RDQTSLQTFCQSLTMKATAMGMNFPRWPDLVKYGRSKEDV--------CTLFTEIADEYRVTNTV 652

  Fly   569 CIC-----HNRRDDRYAAIKKICCSEIPIPSQVINAKTLQNDLKIRSVVQKIVLQMNCKLGG--- 625
            |.|     .::..|.|..:|:.......|.||.:..|.:.....  :....|:|::|.|:||
 Worm   653 CDCIIVVLQSKNSDIYMTVKEQSDIVHGIMSQCVLMKNVSRPTP--ATCANIILKLNMKMGGINS 715

  Fly   626 --------SLWTVKIPFKNVMICGIDSYHDPSN---RGN--SVAAFVASINSSYSQWYSKAVVQT 677
                    :.:.|..|   .|:.|||..| |:.   |.|  ||||.||:::.....:.:...||.
 Worm   716 RIVADQITNKYLVDQP---TMVVGIDVTH-PTQAEMRMNMPSVAAIVANVDLLPQSYGANVKVQK 776

  Fly   678 K-REEIVNGLSASFEIALKMYRKRNGKLPTNIIIYRDGIGDGQLYTCLNYEIPQFEMVC-----G 736
            | ||.:|..|.|..|..:..||....| |..||:||||:.:||....|..||......|     .
 Worm   777 KCRESVVYLLDAIRERIITFYRHTKQK-PARIIVYRDGVSEGQFSEVLREEIQSIRTACLAIAED 840

  Fly   737 NRIKISYIVVQKRINTRIFS-------GSGIHLENPLPGTVVDQHITKSNMYDFFLVSQLVRQGT 794
            .|..|:|||||||.:.|||.       |..   :|..|||.||..|.....:||:|.|....|||
 Worm   841 FRPPITYIVVQKRHHARIFCKFPNDMVGKA---KNVPPGTTVDTGIVSPEGFDFYLCSHYGVQGT 902

  Fly   795 VTPTHYVVLRDDCNYGPDIIQKLSYKLCFLYYNWAGTVRIPACCMYAHKLA 845
            ..|..|.||.|:|.:..|.||.::|.:|..|.....:|.||....||..:|
 Worm   903 SRPARYHVLLDECKFTADEIQNITYGMCHTYGRCTRSVSIPTPVYYADLVA 953

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	37/215 (17%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	135/503 (27%)
alg-3	NP_502217.1	ArgoN	152..233	CDD:465134	16/80 (20%)
		ArgoL1	260..304	CDD:462567	10/45 (22%)
		PAZ_argonaute_like	369..479	CDD:239212	21/118 (18%)
		Piwi_ago-like	525..960	CDD:240015	127/463 (27%)