Protein Alignment AGO3 and hrde-1

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_497834.1
• Gene: hrde-1 / 175535
• WormBaseID: WBGene00007624
• Length: 1032
• Species: Caenorhabditis elegans
• Alignment Length: 664
• Identity: 133/664 - (20%)
• Similarity: 241/664 - (36%)
• Gaps: 150/664 - (22%)

  Fly   303 NVEHYQESARKMLVGNIVLTRYNNRTYKINDICFDQNPTCQFEIKTGC----TSYVEYYKQYHNI 363
            |.:...|.|.|.|  ::..|.......:::.|..:......|.:|...    .:..||:...:||
 Worm   389 NTKRCIEEALKGL--DVECTHLKGNLIRVSSIAENNAENTSFMMKDDKGEREVTVAEYFLLQYNI 451

  Fly   364 NIKDVNQPLIYS--IKKSRGIPAERENLQFCLIPELCYLTGLRDEVRSDNKLMREIATFTRVSPN 426
            .:|....||:.|  .|.....|.|                                  ..|::|.
 Worm   452 KLKYPRLPLVVSKRFKHESFFPME----------------------------------LLRIAPG 482

  Fly   427 QRQMALNKFYENVSNTPAAQEILNSWGLSLTNNSNKI------------SGRQMD---IEQIYFS 476
            || :.:||.      :|..|..:.....|:..:..|:            ..:.||   |:.:...
 Worm   483 QR-IKVNKM------SPTVQSAMTGRNASMPQHHVKLVQDILRDNLKLEQNKYMDAFGIKLMSTE 540

  Fly   477 KISVSA----GRSAEFSKHAVTNEMLKVVHLSKWIIIHLRNYRQAATSLLDN---MKQA---CES 531
            .|.::|    ....:|.......:|.:....::...:.....|:....:.||   |:||   |:.
 Worm   541 PIQMTAKLLPPAQIKFKGQTYMPDMSRPAFRTQDKFVEPARIRKIGIVVFDNCIQMRQAEDFCDK 605

  Fly   532 LGMNISNPTMISLDHDRIDAYIQALRRNITMNTQ------------MVVCICHNRRDDRYAAIK- 583
            |. |......|:::.|..|..|:.|..:.::..|            ::|.|...::.|.:..:|
 Worm   606 LS-NFCRDNGITVEKDSRDWSIRELNSSDSVAIQNLMKKWLDDRVDILVGIAREKKPDVHDILKY 669

  Fly   584 ---KICCSEIPIPSQVINAKTLQNDLKIRSVVQKIVLQMNCKLGGSLWTVKIP------------ 633
               .|....|.:..|.::  .:......|..:..::.:.|.|.||:.:.|:||
 Worm   670 FEESIGLQTIQLCQQTVD--KMMGGQGGRQTIDNVMRKFNLKCGGTNFFVEIPNAVRGKAVCSNN 732

  Fly   634 -------FKNVMICGIDSYHDPS------NRGN-----SVAAFVASINSSYSQWYSKAVVQTKRE 680
                   .::|...|.:..|..|      :|..     ||.....|:.:| :|......:||::|
 Worm   733 ETLRKKLLEHVQFIGFEISHGASRTLFDRSRSQMDGEPSVVGVSYSLTNS-TQLGGFTYLQTQKE 796

  Fly   681 EIVNGLSASFEIALKMYRKRNGKLPTNIIIYRDGIGDGQLYTCLNYEIPQ----FEMV-CGNRIK 740
            ..:..|...|...::.|::.:..|||.|:|||.|.|:|. :..:..|:.:    |:.: .|.|..
 Worm   797 YKLQKLDEFFPKCVRSYKEHSKTLPTRIVIYRVGAGEGN-FNRVKEEVEEMRRTFDKIQPGYRPH 860

  Fly   741 ISYIVVQKRINTRIF----SGSGIHLENPLPGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTHYV 801
            :..|:.|:..:.|:|    ||:....:|...||.|:..:|.....:|.|.||....|||.|..|.
 Worm   861 LVVIIAQRASHARVFPSCISGNRATDQNIPSGTCVENVLTSYGYDEFILSSQTPLIGTVRPCKYT 925

  Fly   802 VLRDDCNYGPDIIQKLSYKLCFLYYNWAGTVRIPACCMYAHKLA------YLIGQ---------- 850
            :|.:|..:..:.:..|:|...|.:........:|.....|..||      |.|.|
 Worm   926 ILVNDAKWSKNELMHLTYFRAFGHQVSYQPPSVPDVLYAAENLAKRGRNNYKIHQRYVNLQAVEN 990

  Fly   851 SIQRDVAEALSEKL 864
            .|.:|.:|.::|.:
 Worm   991 RIIKDHSELINEDM 1004

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	21/127 (17%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	108/523 (21%)
hrde-1	NP_497834.1	PAZ_argonaute_like	389..480	CDD:239212	21/126 (17%)
		Piwi-like	540..974	CDD:239208	93/438 (21%)