Protein Alignment AGO3 and wago-4

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_496751.1
• Gene: wago-4 / 174932
• WormBaseID: WBGene00010263
• Length: 965
• Species: Caenorhabditis elegans
• Alignment Length: 951
• Identity: 204/951 - (21%)
• Similarity: 364/951 - (38%)
• Gaps: 257/951 - (27%)

  Fly    45 LLSSHNIETD-LITTLQHVNISVGRGRARLIDT------------LKT-----DDHTSNQF---- 87
            |.|.:....| .|..|:.:||:..   |:|..|            ::|     :.|..:.|
 Worm    33 LRSEYQTSNDACIKRLEELNIAPA---AKLYPTPTEPGKCGVEAEIQTNVFGIEMHQDSLFYQYS 94

  Fly    88 --ITSESK--ENITKKTKGPESEAIASENGLFFPD----LIYGSKGSSVNIYCNYLKLTTDESKG 144
              ||:|.|  :.:|...||.:...:...:     |    :::.:.|.    |..:.|  |.:|..
 Worm    95 VNITTELKNGKEVTFTKKGKDDFVVTERH-----DKCCAILFRALGD----YEEFFK--TSDSCL 148

  Fly   145 VFNYEVRFFPPIDSVH------LRIKYLN------DHKDKLGGTKTFDGNTLYLPILLPNKMTVF 197
            :::.:...|..:|...      ::.||:.      ||||...           ||.:   |:.||
 Worm   149 IYDGQSILFSNVDLFQGFREGAVKTKYMQLDGGEMDHKDLKS-----------LPCI---KLEVF 199

  Fly   198 ISKAEDVELQIRILYKKKEEMRNCT----QLYNILFDRVMKV----------LNYVKFDR-KQF- 246
            .:|...|:      :.::...|..|    ...::.:.:::::          ..||.||. |.|
 Worm   200 PTKNPAVK------FTREAVARRATDSNLDSVSLAYQQILELALTQPCLRNTARYVVFDHGKMFF 258

  Fly   247 -DP-----SRPKIIPLAK-LEVWPGYVTAVDEYKG--------------GLMLCCDVSHRILCQK 290
             ||     .:..::.:.. .:|.||....::..:|              |:.:   ..|:   .:
 Worm   259 IDPLGEGFEKCDVVDVGDGKQVVPGLKKTINFIEGPYGRGRSNPSVVIDGMKV---AFHK---NQ 317

  Fly   291 TVLEMLVDLYQQNVEHYQESARK-----MLVGNIVLTRYNNRT--YKINDICFDQNPTCQFEIKT 348
            .:|:.|.::..|.|||..:...|     ::.|....:.|..|.  :||..|..:.....:||:..
 Worm   318 PILDKLKEITTQPVEHGLKGLEKDRCAAVIKGLDCYSTYGGRERHHKIEGIHHEGARNARFELND 382

  Fly   349 G--CTSYVEYYKQYHNINIKDVNQPLIYSIKKSRG----IPAERENL---QFCLIPELCYLTGLR 404
            |  || ..:|::..:||.::..:..||  :.|.||    .|.|...:   |...||:   ||..:
 Worm   383 GGSCT-VAQYFEDVYNITLRYPDTNLI--VSKERGNINFYPMELLKISSHQRVQIPQ---LTSAQ 441

  Fly   405 DEVRSDNKLMREIATFTRVSPNQRQMALNKFYENVSNTPAAQEILNSWGLSLTNNSNKISGRQMD 469
            .:     |..:|.|....|  .||.:...|   |.:...:..|:|...|:|:..:...:.||.:.
 Worm   442 SQ-----KTTKESAVLPDV--RQRLILTGK---NAAQISSDNEVLGKMGVSVCEDPLMVKGRSIP 496

  Fly   470 IEQIYFSKISV-------SAGRSAEFSKHAVTNEMLKVVHLSKWIIIHLRNYRQAATSL-LDNMK 526
            ..::..::|..       :..|:..|::.|....:        |.:..:..   |:|.: ||.:|
 Worm   497 AVKLANAEIGANPINVKDNKWRANRFTRPATAPNV--------WAMYVVGT---ASTRITLDTLK 550

  Fly   527 Q-------ACESLGMNISNPTMISLDH-DRIDAYI-QALRRNIT---MNTQMVVCICHNRRDDRY 579
            :       .|:|.|:|:..|..|||.| |.|::.: .|.:.|.|   :.|...:...|    .||
 Worm   551 KFADEFAAMCKSKGVNMPAPADISLIHMDAIESRLYDATKANCTFVFIITDDSITTLH----QRY 611

  Fly   580 AAIKKICCSEIPIPSQVINAKTLQNDLKI-----------RSVVQKIVLQMNCKLGGSLWT---V 630
            ..|:|             :.|.:..|:|:           |..::.::.:.|.|||||.:.   .
 Worm   612 KMIEK-------------DTKMIVQDMKLSKALSVINAGKRLTLENVINKTNVKLGGSNYVFVDA 663

  Fly   631 KIPFKNVMICGIDSYHDPS-------NRG----NSVA-AFVASINSSYSQWYSKAVVQTKREEIV 683
            |....:.:|.|:.....|:       |:|    |.:. |:.|..|..:|   ...|:.:..::.:
 Worm   664 KKQLDSHLIIGVGISAPPAGTKYAMENKGVLNPNVIGYAYNAQHNQEFS---GDFVLNSASQDTL 725

  Fly   684 NGLSASFEIALKMYRK-RNGKLPTNIIIYRDGIGDGQLYTCLNYEIPQFEMVCGN---RIKISYI 744
            ..:......:|..|:| .:|.||..:|:||.|..:|...:.:.||||.......:   .|::.||
 Worm   726 APIEDIVMHSLNEYQKFHDGGLPRRVIVYRTGTSEGNHGSIMAYEIPLARAAMRDFSPDIQLVYI 790

  Fly   745 VVQKRINTRIF---------------SGSGIHLENP----------LPGTVVDQHITKSNMYDFF 784
            ||.|..:.|.|               |.:..|...|          .||.:||..:|......||
 Worm   791 VVSKDHSFRFFKPDLASLASRPQATSSTASRHSAMPAAPKAWDLNIAPGILVDSIVTNPACKQFF 855

  Fly   785 LVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYKLCFLY 825
            |.|.:..|||.....|.||.||.......::.::||||.|:
 Worm   856 LNSHITLQGTAKTPLYTVLADDAKVSMTALEDITYKLCHLH 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	37/149 (25%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	114/489 (23%)
wago-4	NP_496751.1	PLN03202	67..897	CDD:215631	194/914 (21%)
		PAZ_argonaute_like	316..426	CDD:239212	28/112 (25%)
		Piwi	594..924	CDD:396649	77/323 (24%)