Protein Alignment AGO3 and alg-5

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_001370006.1
• Gene: alg-5 / 172861
• WormBaseID: WBGene00011945
• Length: 905
• Species: Caenorhabditis elegans
• Alignment Length: 925
• Identity: 192/925 - (20%)
• Similarity: 358/925 - (38%)
• Gaps: 217/925 - (23%)

  Fly    73 LIDTLKTDDHTSNQFITSESKENITKKTKGPESEAIASENGLFFPDLIY---------------- 121
            |::.||....||:: .||.:..::       |:|.::|.:|....|.:|
 Worm    15 LVEKLKVRSSTSSR-STSINVPSL-------ENEFLSSSSGSRVSDDLYLHPIEENREPFKLIGK 71

  Fly   122 ---GSKGSSVNIYCNYLKLTTDESKGVFNYEVRFFPPIDSVHLRIKYLNDHKDKLGG----TKTF 179
               .:.|..:::..|:.::|.:.|. :..|.:||.|.|.|..|....|...:::..|    ...|
 Worm    72 PLPSTTGRFLSLLANHFQITCNGSI-IHQYYIRFDPDIPSKKLNRTILRTLQEQNPGLIECPLVF 135

  Fly   180 DG-NTLYLPILL---------------------PNKMTVFISKAEDVELQIRILYKKKEEMRNCT 222
            || :|:|...|:                     ||...::::..:...|..:|:...:::.:...
 Worm   136 DGIHTVYSTELINVKEVNNSVINVAGVVNTKESPNLFKLYLTHVDSFLLDTKIITGNQDQNQKLR 200

  Fly   223 QLYNILFDRVMKVLNYVKF-----------DRKQFDPSRPKIIPLAKL----EVWPGYVTAVDEY 272
            .::.|  |.|.:..:...|           .....:||.........|    ||..|:...|.|.
 Worm   201 MMHAI--DTVFRQTSTGNFHAVLQSFFSIAQNSAIEPSHGLGWGTVNLGVGREVCYGFYQNVVET 263

  Fly   273 KGGLMLCCDVSHRILCQKTVL-EMLVDLYQ---------QNVEHYQESA-RKMLVGNIVLTRYNN 326
            ...|.:..||:.....:...| |.|.::.:         :::...|:.. .:.:.|..|.||:.:
 Worm   264 FDTLTMNLDVATTTFYRPVALVEFLAEILEVPLATVTDGRSLSDVQKKKFNREVAGLKVETRHCS 328

  Fly   327 --RTYKINDICFDQNPTCQFEIKTGC-------TSYVEYYKQYHNINIKDVNQPLIYSIKKSRGI 382
              |.:::....:.......|.:....       .|.|||||:.:||::...:.|.|       .:
 Worm   329 CPRRFRVARCTWKPTENISFHLSETAGNQDSKPLSLVEYYKRRYNIDLTYKHLPCI-------EV 386

  Fly   383 PAERENLQFCLIP-ELCYLTGLRDEVRSDNKLMREIATFTRV---SPNQRQMALNKFYENVSNTP 443
            ...||    |::| ||||:...:..::..|:  ::||...|.   :..:||.|:    .::.|..
 Worm   387 GRTRE----CILPLELCYVVSGQRCIKKLNE--QQIANLIRATSRNATERQNAV----MSLQNRL 441

  Fly   444 AAQEILNS--WGLSLTNNSNKISGRQMDIEQIYFSKISVSAGRSAEFSK-HAVT----------- 494
            .....:|:  :||.:.....||.||.:.:.::.:        ||....: ..||
 Worm   442 KMDNDVNAVKFGLKVEAQLLKIEGRVLPVPRLLY--------RSPNLKRQECVTVPNNGTWDMRG 498

  Fly   495 NEMLKVVHLSKWIIIHLRN----YRQAATSLLDNMKQACESLGMNISNPTMISLDHDRI------ 549
            ......:.:.:|.|:...:    ...:..|.:.|:......:||..       |:..|.
 Worm   499 KNFYSGIQIREWAIVCFASPEIIGEASMRSFVRNLVNVASEIGMPF-------LEEHRFCRYAEP 556

  Fly   550 DAYIQALRR-NITMNTQMVVCICHNRRDDRYAAIKKICCSEIPIPSQVINAKT----LQNDLKIR 609
            |..::.|.. |...|.|:|:||...         |.:...|:....:::...|    .||..|..
 Worm   557 DQTVKLLEHLNEQYNLQLVLCIVPG---------KSVVYGELKRKGELLGLTTQCVRSQNVSKAS 612

  Fly   610 -SVVQKIVLQMNCKLGG----------SLWTVKIPF------KNVMICGIDSYHDPSNRGNSVAA 657
             ..:..:.:::|.||||          ||.:..:.|      ::.:....||....::..:|:|.
 Worm   613 PHTLSNLCMKINSKLGGINVILSSPPQSLNSEPVLFIGCHLTRSSLASSSDSTSSIAHCDSSIAC 677

  Fly   658 FVASINSSYSQW---------YSKAVV---QTKREEIVNGLSASFEIALKMYRKRNGKLPTNIII 710
            .|.|::...:|:         :.:.:|   :..||.|:|            :||..|..|..|||
 Worm   678 LVGSMDGHPTQFSPIFRTQPRHQRTIVDMCEMTREAIIN------------FRKSTGFKPHKIII 730

  Fly   711 YRDGIGDGQLYTCLNYEIPQFEMVC-----GNRIKISYIVVQKRINTRIFSGS-----GIHLENP 765
            ||.||.|..:...:..|:......|     |.:..|::|.:....:||:|:.:     | :.:|.
 Worm   731 YRAGIADVTVDEIMQTELRAVRDACAMIEYGFQPGITFIGLDVTHHTRLFAANEKDRVG-NSQNV 794

  Fly   766 LPGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYKLCFLYYNWAG 830
            ..||:|:..||.:|:::|:|||....|||..||.|||:.||.:.....|.:::|:||........
 Worm   795 PAGTLVETGITVNNLFEFYLVSHAGIQGTSRPTKYVVMWDDNSIPSADIHEMTYQLCHTQSRCTR 859

  Fly   831 TVRIPACCMYAHKLA 845
            :|.||:...||..:|
 Worm   860 SVSIPSPVYYAKLVA 874

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	32/157 (20%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	112/505 (22%)
alg-5	NP_001370006.1	ArgoL1	219..280	CDD:462567	11/60 (18%)
		PAZ	310..420	CDD:460472	27/122 (22%)
		Piwi_ago-like	448..881	CDD:240015	105/464 (23%)