Protein Alignment AGO3 and ppw-1

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_491323.2
• Gene: ppw-1 / 172013
• WormBaseID: WBGene00004093
• Length: 887
• Species: Caenorhabditis elegans
• Alignment Length: 948
• Identity: 183/948 - (19%)
• Similarity: 327/948 - (34%)
• Gaps: 313/948 - (33%)

  Fly    98 KKTKGPESEAIASENGLFFPDLIYGSKGSSVNIYCNYLKLTTDESKGVFNYEVR---FFPPIDSV 159
            |||:..|                   :|:.|||..|..|||...::.::.|.|:   .|...|..
 Worm    30 KKTRNVE-------------------RGTKVNIDTNIRKLTIKPNQPIYKYAVQVNYVFRKPDGT 75

  Fly   160 HLRIKYLNDHKDKLGGTKTFDGNTLYLPILLPNKMTVFISKAEDVELQIRILYKKKEEMRNCTQL 224
            ...|:.....|.   ||:..:..|....:.  |:.   |.:.::::......|.::..:...|:|
 Worm    76 EATIEMSKSAKK---GTEHDNDKTRCQKVY--NEA---IKRYDELKTGGPFFYDRQASLYTLTKL 132

  Fly   225 YN-----ILFDRVMKVLNY--VKFDRKQFDPS--------------------------------- 249
            .|     ::.|::.|..|:  .:|..|:.|.|
 Worm   133 KNESISFVVTDKICKRQNFKEAQFVLKKVDQSFQSTSNDVIRTTNSCPANADKTLLEAMNIIVSG 197

  Fly   250 -------------------RPKIIPLAKLEVWPGY-------------VTAVDEYKGGLMLCCDV 282
                               .|.::.:|..|...|.             :...|:....|.:..::
 Worm   198 PAFENKNVITVGACVHYLIDPTVVDVAYKEYAEGQLYSGVGASKSVKTLEGTDKKVPSLFMTTEM 262

  Fly   283 SHRILCQKTVL-----EMLVDLYQ----------------QNVEHYQESARKMLVGNIVLTRY-- 324
                   ||.|     ..||:|.|                |.:|       |..||..|:..|
 Worm   263 -------KTTLFHPDYAPLVELLQTFRGFSTTLKANSPAAQRIE-------KAFVGLDVVLNYGV 313

  Fly   325 ------NNRTYKINDICFDQNPTCQFEIKTGC---TSYVEYYKQYHNINIKDVNQPLIYSI--KK 378
                  :....||.........|| ||::...   |:..:|:|:.:.|.:|   .|.:::|  |.
 Worm   314 HKGLGEDGVVMKIRRFHTSAKETC-FEVEKSTREFTNVFDYFKKKYGITLK---YPDLFTIEAKG 374

  Fly   379 SRG---IPAERENLQFCLIPELCYLTGLRDEVRSDNKLMREIATFTRVS---PNQRQMALNKFYE 437
            .:|   .|||        :..||    ....|.:|..:..|.|...::|   |:.|:...:....
 Worm   375 KQGKIHFPAE--------VLLLC----PNQTVTNDQMINNEQADMIKMSAAQPHIRKTTTDTIVR 427

  Fly   438 NV---SNTPAAQEILNSWGLSLTNNSNKISGRQMDIEQIYF------------SKISVSAGRSAE 487
            ||   ||        |.:|.....:...:.|..:...:|.|            |:......|:.:
 Worm   428 NVGLASN--------NIYGFIKVEDPVNLEGMVLPKPKIAFAGNQLADLANPKSRFPTDFNRAGQ 484

  Fly   488 FSKHAVTNEMLKVVHLSKWIIIHLRN------YRQAATSLLDNMKQACESLGMNISNPTMISLDH 546
            :         .....|:||.::.::|      .:|.|..:::|        ||..|||||..:..
 Worm   485 Y---------YDAKELTKWELVFVQNEEVQGLAKQLADEMVNN--------GMKCSNPTMSFIIR 532

  Fly   547 DRIDAYIQALRRNITMNTQMVVCICHNRRDDRYAAIKKICCSEIPIPSQVINAKTLQNDLKIRSV 611
            ..::...:..:   ...||::..:..:|.:  |....|....:..:.:|.|.|:|.:...:....
 Worm   533 GDLEPIFKKAK---AAGTQLLFFVVKSRYN--YHQQIKALEQKYDVLTQEIRAETAEKVFRQPQT 592

  Fly   612 VQKIVLQMNCKLGGSLWTVKIPFKNVMICGIDSYHDPSNRGNSVAAFVASI----NSSY------ 666
            ...|:.:.|.||||..:.:          |.::::.| ||  .:..||.|.    |..|
 Worm   593 RLNIINKTNMKLGGLNYAI----------GSEAFNKP-NR--LIVGFVTSQRVGGNPDYPISVGF 644

  Fly   667 -------SQWYSKAVVQTKREEIVNG------LSASFEIALKMYRKRNGKLPTNIIIYRDGIGDG 718
                   .|.::...|...|:..|.|      |.|.|    |...::.|: |.:|::|.:|:.:|
 Worm   645 AANMLKHHQKFAGGYVYVHRDRDVFGSIIKDTLLAIF----KTCTEQRGR-PDDILLYFNGVSEG 704

  Fly   719 QLYTCLNYEI----------------PQFEMVCGNRIKISYIVVQKRINTRIFSGSGIHLENPLP 767
            | ::.:|.|.                |.|      |..|:.|...|..|.|::......:.|..|
 Worm   705 Q-FSMINEEFSARVKEACMAFQKEGTPPF------RPHITIIASSKAHNERLYKSDKGRIVNLEP 762

  Fly   768 GTVVDQHITKSNMY-DFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDI-----IQKLSYKLCFLYY 826
            ||||| |...||:| :::..|.:.||||...|.:.:: .....||..     :::|:..||
 Worm   763 GTVVD-HTIVSNVYTEWYHASAVARQGTAKATKFTLI-FTTKAGPQAEPLWHLEQLTNDLC---- 821

  Fly   827 NWAGTVRIPACCMYAHKLAY-LIGQSIQRDVAEALSEK 863
                         |.|::.: .:|..:...:|:..|::
 Worm   822 -------------YDHQIVFHPVGLPVPLYIADRYSQR 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	38/173 (22%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	104/507 (21%)
ppw-1	NP_491323.2	PAZ_argonaute_like	272..389	CDD:239212	29/135 (21%)
		Piwi-like	444..849	CDD:239208	96/469 (20%)