DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AGO3 and PIWIL4

DIOPT Version :9

Sequence 1:	NP_001036627.2	Gene:	AGO3 / 3355150	FlyBaseID:	FBgn0250816	Length:	867	Species:	Drosophila melanogaster
Sequence 2:	NP_689644.2	Gene:	PIWIL4 / 143689	HGNCID:	18444	Length:	852	Species:	Homo sapiens

Alignment Length:	888	Identity:	299/888 - (33%)
Similarity:	476/888 - (53%)	Gaps:	57/888 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGRGNLLSLFNKNAGNMGKSISSKD------HEIDSGLDFNNSESSGERLLSSHNIETDLITTL 59
            ||||..:      .|..:.:|.|:.:      ..:...:|.:|:|:|.    |:..:.|..|:|.
Human     1 MSGRARV------KARGIARSPSATEVGRIQASPLPRSVDLSNNEASS----SNGFLGTSRISTN 55

  Fly    60 QHVNISVGRGRARLID--TLKTDDHTSNQFITSESKENITK-KTKGPESEAIASENGLFFPDLIY 121
            ....||.|...:..::  .....|.......|.|...::.. ||
Human    56 DKYGISSGDAGSTFMERGVKNKQDFMDLSICTREKLAHVRNCKT--------------------- 99

  Fly   122 GSKGSSVNIYCNYLKLTTDESKGVFNYEVRFFPPIDSVHLRIKYLNDHKDKLGGTKTFDGNTLYL 186
            ||.|..|.:..|...|...:...::.|.|.:.|.:.|..|||..|..|.:.....|.|||..|:|
Human   100 GSSGIPVKLVTNLFNLDFPQDWQLYQYHVTYIPDLASRRLRIALLYSHSELSNKAKAFDGAILFL 164

  Fly   187 PILLPNKMTVFISKAEDVELQIRILYKKKEEMRN----CTQLYNILFDRVMKVLNYVKFDRKQFD 247
            ...|..|:|...|:.:..| .|::....|.|:.:    |.|::||:|.:::|.|:..:..|..::
Human   165 SQKLEEKVTELSSETQRGE-TIKMTITLKRELPSSSPVCIQVFNIIFRKILKKLSMYQIGRNFYN 228

  Fly   248 PSRPKIIPLAKLEVWPGYVTAVDEYKGGLMLCCDVSHRILCQKTVLEMLVDLYQQ-NVEHYQESA 311
            ||.|..||..||.:|||:..:|..::..|:...|||:::|..:||||.:..|.|: .:..:.::.
Human   229 PSEPMEIPQHKLSLWPGFAISVSYFERKLLFSADVSYKVLRNETVLEFMTALCQRTGLSCFTQTC 293

  Fly   312 RKMLVGNIVLTRYNNRTYKINDICFDQNPTCQFEIKTGC-TSYVEYYKQYHNINIKDVNQPLIYS 375
            .|.|:|.|||||||||||.|:||.:...||..|:.:.|. .:||:||||.::|.:.|:|||::.|
Human   294 EKQLIGLIVLTRYNNRTYSIDDIDWSVKPTHTFQKRDGTEITYVDYYKQQYDITVSDLNQPMLVS 358

  Fly   376 -IKKSRGIPAERENLQFCLIPELCYLTGLRDEVRSDNKLMREIATFTRVSPNQRQMALNKFYENV 439
             :||.|...:|.:...  ||||||:||||.|:..||.:||:.:|..||:||:.||..|.:..:|:
Human   359 LLKKKRNDNSEAQLAH--LIPELCFLTGLTDQATSDFQLMKAVAEKTRLSPSGRQQRLARLVDNI 421

  Fly   440 SNTPAAQEILNSWGLSLTNNSNKISGRQMDIEQIYFSKISVSAGRSAEFSKHAVTNEMLKVVHLS 504
            .....|:..|.:|||.. .:...::||.:..|:|...........:|::||...|.::|....|:
Human   422 QRNTNARFELETWGLHF-GSQISLTGRIVPSEKILMQDHICQPVSAADWSKDIRTCKILNAQSLN 485

  Fly   505 KWIIIHLRNYRQAATSLLDNMKQACESLGMNISNPTMISLDHDRIDAYIQALRRNITMNTQMVVC 569
            .|:|:........|.|.|:.:::...|:|.|:..|.:|.:..:.. |:::|:::.:..:.|:|:|
Human   486 TWLILCSDRTEYVAESFLNCLRRVAGSMGFNVDYPKIIKVQENPA-AFVRAIQQYVDPDVQLVMC 549

  Fly   570 ICHNRRDDRYAAIKKICCSEIPIPSQVINAKTLQNDLKIRSVVQKIVLQMNCKLGGSLWTVKIPF 634
            |..:.:...|.:|||...|:.|:|||.:.|:||.....:.|:..||.:||.|||||.||.|:||.
Human   550 ILPSNQKTYYDSIKKYLSSDCPVPSQCVLARTLNKQGMMMSIATKIAMQMTCKLGGELWAVEIPL 614

  Fly   635 KNVMICGIDSYHDPSNRGNSVAAFVASINSSYSQWYSKAVVQTKREEIVNGLSASFEIALKMYRK 699
            |::|:.|||...|..::...|...|||:|...::|:|:.::|....::.:.|......||..:.|
Human   615 KSLMVVGIDVCKDALSKDVMVVGCVASVNPRITRWFSRCILQRTMTDVADCLKVFMTGALNKWYK 679

  Fly   700 RNGKLPTNIIIYRDGIGDGQLYTCLNYEIPQF-----EMVCGNRIKISYIVVQKRINTRIFSGSG 759
            .|..||..||:||.|:|||||.|.:.||:||.     |.......::|.|||:|:...|.|:...
Human   680 YNHDLPARIIVYRAGVGDGQLKTLIEYEVPQLLSSVAESSSNTSSRLSVIVVRKKCMPRFFTEMN 744

  Fly   760 IHLENPLPGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYKLCFL 824
            ..::||..|||||...|::..|||:|:||:..:|||:||:|.|:.||....||.:|:|::|||.|
Human   745 RTVQNPPLGTVVDSEATRNEWYDFYLISQVACRGTVSPTYYNVIYDDNGLKPDHMQRLTFKLCHL 809

  Fly   825 YYNWAGTVRIPACCMYAHKLAYLIGQSIQRDVAEALSEKLFYL 867
            ||||.|.|.:||.|.|||||.:|:.|||.::.:..|:..||||
Human   810 YYNWPGIVSVPAPCQYAHKLTFLVAQSIHKEPSLELANHLFYL 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	61/136 (45%)
AGO3	NP_001036627.2	Piwi_piwi-like_Euk	412..850	CDD:240016	159/442 (36%)
PIWIL4	NP_689644.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		12/56 (21%)
		PAZ_piwi_like	270..386	CDD:239211	52/117 (44%)
		Piwi_piwi-like_Euk	394..835	CDD:240016	159/442 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147168
Domainoid	1	1.000	316	1.000	Domainoid score	I1269
eggNOG	1	0.900	-	-		E1_KOG1042
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	621	1.000	Inparanoid score	I880
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54391
OrthoDB	1	1.010	-	-		D220258at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40457
orthoMCL	1	0.900	-	-		OOG6_100694
Panther	1	1.100	-	-	O	PTHR22891
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X548
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.810