Protein Alignment AGO3 and ago4

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: NP_001239488.1
• Gene: ago4 / 100535764
• ZFINID: ZDB-GENE-030131-5357
• Length: 863
• Species: Danio rerio
• Alignment Length: 876
• Identity: 194/876 - (22%)
• Similarity: 351/876 - (40%)
• Gaps: 186/876 - (21%)

  Fly   122 GSKGSSVNIYCNYLKLTTDESKGVFNYEVRFFPP----------IDSV--HLRIKYLNDHKDKLG 174
            |:.|..:.:..|:.::...:. .|::|::...|.          :|::  |.:::...|.:....
Zfish    24 GTVGKPIRLLANHFQVQIPKI-DVYHYDIDIKPEKRPRRVNREVVDTMVRHFKMQIFGDRQPGYD 87

  Fly   175 GTKT--------FDGNTLYLPILLPNK-----MTVFISKAEDVELQI---RILYKKKEEMRNCTQ 223
            |.:.        ...:.:.|.:.||.:     ..|.:.....|.||:   .:.....|...:..|
Zfish    88 GKRNMYTAHPLPIGRDRVDLEVTLPGEGKDQTFKVSLQWVSVVSLQMLLEALSGHLNEVPEDSVQ 152

  Fly   224 LYNILFDRVMKVLNYVKFDRKQFDPSRPKIIPL-AKLEVWPGYVTAVDEYKGGLMLCCDVSHRIL 287
            ..::: .|.:..:.|....|..|.|......|| ...|||.|:..:|......:||..|||....
Zfish   153 ALDVI-TRHLPSMRYTPVGRSFFSPPEGYYHPLGGGREVWFGFHQSVRPAMWNMMLNIDVSATAF 216

  Fly   288 CQ-KTVLEMLVDLYQ-QN--------------------------VEHYQESARKMLVGNIVLTRY 324
            .: :.|:|.:.::.. ||                          |.|..:..||..|.|:.....
Zfish   217 YRAQPVIEFMCEVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPA 281

  Fly   325 NNRTYKINDICFDQNPTCQFEIKTG----CTSYVEYYKQYHNINIKDVNQPLIY--SIKKSRGIP 383
            :::|:.:             :::.|    || ..:|:||.:::.:|..:.|.:.  ..:|...:|
Zfish   282 SHQTFPL-------------QLENGQAMECT-VAQYFKQKYSLQLKYPHLPCLQVGQEQKHTYLP 332

  Fly   384 AERENL---QFCLIPELCYLTGLRDEVRSDNKLMREIATFTRVSPNQRQMALNKFYENVSNTPAA 445
            .|..|:   |.|:            :..:||:....|....|.:|: ||..:::..::.|.....
Zfish   333 LEVCNIVAGQRCI------------KKLTDNQTSTMIKATARSAPD-RQEEISRLVKSNSMVGGP 384

  Fly   446 QEILNSWGLSLTNNSNKISGRQMDIEQIYFSKISVSAGRSAEFSKHAVT----------NEMLKV 500
            ...|..:|:.:.|:..:::||.:....:.:      .||    :|...|          .:....
Zfish   385 DPYLKEFGIVVHNDMTEVTGRVLPAPMLQY------GGR----NKTVATPNQGVWDMRGKQFYAG 439

  Fly   501 VHLSKWIIIHLRNYRQAATSLL----DNMKQACESLGMNISNPTMI---SLDHDRIDAYIQALRR 558
            :.:..|.:......:|....||    |.:::..:..||.|......   :...|.::...:.|:.
Zfish   440 IEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKM 504

  Fly   559 NITMNTQMVVCICHNRRDDRYAAIKKICCSEIPIPSQVINAKTLQNDLKIR-SVVQKIVLQMNCK 622
            :. :..|::|.|... :...||.:|::..:.:.:.:|.:..|   |.:|.. ..:..:.|::|.|
Zfish   505 SY-VGLQLIVVILPG-KTPVYAEVKRVGDTLLGMATQCVQVK---NVVKTSPQTLSNLCLKINAK 564

  Fly   623 LGGSLWTVKIPFKN-------VMICGIDSYHDPSNRGN--SVAAFVASINSSYSQWYSKAVVQTK 678
            ||| :..|.:|.:.       |:..|.|..|.|:..|.  |:||.|.|::...|::.:...|||.
Zfish   565 LGG-INNVLVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDGHPSRYCATVRVQTS 628

  Fly   679 R----------EEIVNGLSASF-EIALKMYRKRNGKLPTNIIIYRDGIGDGQLYTCLNYEIPQFE 732
            |          :|::..|:... |:.::.|:....| ||.||.||.|:.:||:......|:....
Zfish   629 RQDLSQEQLFSQEVIQDLTNMVRELLIQFYKSTRFK-PTRIIYYRGGVSEGQMKQVAWPELIAIR 692

  Fly   733 MVC-----GNRIKISYIVVQKRINTRIFSG--------SGIHLENPLPGTVVDQHITKSNMYDFF 784
            ..|     ..|..|:|||||||.:||:|..        ||    |...||.||..||..:.:||:
Zfish   693 KACISLEEDYRPGITYIVVQKRHHTRLFCSDKAERVGKSG----NVPAGTTVDSTITHPSEFDFY 753

  Fly   785 LVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYKLCFLYYNWAGTVRIPACCMYAHKLAY--- 846
            |.|....|||..|:||.||.||..:..|.:|.|:|:||..|.....:|.|||...||..:|:
Zfish   754 LCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVAFRAR 818

  Fly   847 ---------------LIGQSIQRDVAEALSE 862
                           :.|||..|| .:||::
Zfish   819 YHLVDKDHDSAEGSHVSGQSNGRD-PQALAK 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	29/169 (17%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	124/506 (25%)
ago4	NP_001239488.1	ArgoN	28..157	CDD:465134	17/129 (13%)
		ArgoL1	168..218	CDD:462567	15/49 (31%)
		PAZ_argonaute_like	219..339	CDD:239212	23/133 (17%)
		Piwi_ago-like	386..821	CDD:240015	118/455 (26%)