Protein Alignment AGO3 and piwil3

DIOPT Version :10

• Sequence 1: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Sequence 2: XP_031752134.1
• Gene: piwil3 / 100496286
• XenbaseID: XB-GENE-6469412
• Length: 869
• Species: Xenopus tropicalis
• Alignment Length: 831
• Identity: 314/831 - (37%)
• Similarity: 482/831 - (58%)
• Gaps: 67/831 - (8%)

  Fly    60 QHVNISVGRGRAR-----LIDTLKTDDHTSNQFITSESKENITKKTKGPESEAIASENGLFFPDL 119
            |.|.||...||.|     .::|.:|.:|.         ||:.|
 Frog    83 QEVTISERGGRRRDFHDLGVNTRQTIEHV---------KESKT---------------------- 116

  Fly   120 IYGSKGSSVNIYCNYLKLTTDESKGVFNYEVRFFPPIDSVHLRIKYLNDHKDKLGGTKTFDGNTL 184
              |..||::.:..|::||.:.....::.|.:.:.|.::|..||...|..|::.:|..:.|||..|
 Frog   117 --GVSGSTIQLSTNHIKLVSRPQWVLYQYHIDYNPQMESRRLRTALLYQHEELIGKARAFDGTML 179

  Fly   185 YLPILLPNKMTVFISK---AEDVELQIRILYKKKEEMRNCTQLYNILFDRVMKVLNYVKFDRKQF 246
            :.|..| ||.|...|:   .|:|::.|.:..:.......|.|.|||:|.|::|::|..:..|..:
 Frog   180 FAPKRL-NKATEVFSQTRNGENVKITITLTNELPPTSPTCFQFYNIIFRRLLKMMNMKQIGRNYY 243

  Fly   247 DPSRPKIIPLAKLEVWPGYVTAVDEYKGGLMLCCDVSHRILCQKTVLEMLVDLYQQNVEH-YQES 310
            :||.|..|....|.:|||:.|::.:|:..:||..||||::|..:|||:::..||:.:.:. :.::
 Frog   244 NPSDPIEISQHNLTIWPGFTTSILQYETSIMLSLDVSHKVLRSETVLDVMTKLYRMHGDRDFADA 308

  Fly   311 ARKMLVGNIVLTRYNNRTYKINDICFDQNPTCQFEIKTGC-TSYVEYYKQYHNINIKDVNQPLIY 374
            ..|.|:|.||||:|||:||:|::||::..|...|:...|. .|:|:||:..:|..|:|:.|.||.
 Frog   309 VTKELLGQIVLTKYNNKTYRIDEICWNMTPQSTFKKSDGSDISFVDYYRMQYNKEIRDLRQALIA 373

  Fly   375 SIKKSRGIPAERENLQFCLIPELCYLTGLRDEVRSDNKLMREIATFTRVSPNQRQMALNKFYENV 439
            :|  .|.:....:.....|:||||.||||.|.:|:|..:||::|..||:.|:||:..:.:|...:
 Frog   374 NI--PRRVRPGGDTGPIVLVPELCNLTGLTDRMRNDFGVMRDLAVHTRLPPDQREKQVARFLNYI 436

  Fly   440 SNTPAAQEILNSWGLSLTNNSNKISGRQMDIEQIYFSKISVSAGRSAEF-------SKHAVTNEM 497
            ......|:.|..|||:.........||....|:|      :.|||:|::       |:......:
 Frog   437 HKDENVQKELRDWGLNFDKQLLPFVGRVSPPERI------LQAGRTADYNPQFADWSREMRGQTL 495

  Fly   498 LKVVHLSKWIIIHLRNYRQAATSLLDNMKQACESLGMNISNPTMISLDHDRIDAYIQALRRNITM 562
            :.|.||..|::::.|....||.:|:..:.:..:.:||.::|..|..:| ||.::|||.|...:..
 Frog   496 ISVRHLDNWMLLYPRRCYDAAQTLVQTLNKVAQQIGMRMNNVRMFEVD-DRANSYIQVLNAEVNP 559

  Fly   563 NTQMVVCICHNRRDDRYAAIKKICCSEIPIPSQVINAKTLQNDLKIRSVVQKIVLQMNCKLGGSL 627
            :||||||:..:...::|.:|||..|.:||.|||.:.|:||.....:.||..||.:|||||:||.|
 Frog   560 DTQMVVCVLSSIHKEKYDSIKKYLCLQIPTPSQCVVARTLSKPQTVLSVATKIAMQMNCKMGGEL 624

  Fly   628 WTVKIPFKNVMICGIDSYHDPSNRGNSVAAFVASINSSYSQWYSKAVVQTKREEIVNGLSASFEI 692
            |:|:||...:|:.|||.|||..:...|:|.||||:|.:.::|||:.|:|.:::|||:||....:.
 Frog   625 WSVEIPLGEMMVIGIDCYHDTLSGKRSIAGFVASMNRNLTRWYSRCVLQDQKQEIVDGLKVCLQA 689

  Fly   693 ALKMYRKRNGKLPTNIIIYRDGIGDGQLYTCLNYEIPQFEMVCGNRI------KISYIVVQKRIN 751
            :|..:...|..||:.|:|||||:|||||.|.:||||||| :.|....      |:|.|||:||||
 Frog   690 SLHAWFNCNKNLPSRILIYRDGVGDGQLKTLVNYEIPQF-LDCIKSAGRDYCPKLSIIVVKKRIN 753

  Fly   752 TRIFSGSGIHLENPLPGTVVDQHITKSNMYDFFLVSQLVRQGTVTPTHYVVLRDDCNYGPDIIQK 816
            .|.|:..|..::||.||||||..:|:...||||:|||.||||||:||||.|:.|.....||.:|:
 Frog   754 ARFFAHLGGRIQNPPPGTVVDVEVTRPEWYDFFIVSQSVRQGTVSPTHYNVVYDSSGLKPDYMQR 818

  Fly   817 LSYKLCFLYYNWAGTVRIPACCMYAHKLAYLIGQSIQRDVAEALSEKLFYL 867
            |:||||.|||||.|.:|:||.|.||||||:|:||||.::...|||.:|:||
 Frog   819 LTYKLCHLYYNWPGVIRVPAPCQYAHKLAFLVGQSIHKEPHLALSNRLYYL 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	52/135 (39%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	190/450 (42%)
piwil3	XP_031752134.1	GAGE	<75..117	CDD:461753	13/66 (20%)
		PAZ	287..423	CDD:198017	52/137 (38%)
		Piwi_piwi-like_Euk	410..852	CDD:240016	190/449 (42%)