DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12547 and AT1G56500

DIOPT Version :9

Sequence 1:	NP_001036460.1	Gene:	CG12547 / 3355145	FlyBaseID:	FBgn0250830	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_564718.2	Gene:	AT1G56500 / 842103	AraportID:	AT1G56500	Length:	1055	Species:	Arabidopsis thaliana

Alignment Length:	724	Identity:	267/724 - (36%)
Similarity:	381/724 - (52%)	Gaps:	109/724 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LLQAYKSSKGENEKAGTIVKFLDRWNDDISIAKLKDLTVEFESDLEWFNVSCPLSI-KGLQGKVI 83
            |:.|...|..:|:..|.:.:|:| :..|:...:......||.|.|:|.| :.||.. :.|:|||:
plant   360 LVGAKSPSFTQNQGEGRVQQFVD-YIADLESKQTATTVPEFPSKLDWLN-TAPLQFRRDLKGKVV 422

  Fly    84 ILDFFTYCCINCMHVLQELHLLEERFPIESGVVVIGVHSPKFENERNAANILSAVQRYGISHPIV 148
            ||||:|||||||||||.:|..||:::. :....|:||||.||:||::...|.:||.||.||||:|
plant   423 ILDFWTYCCINCMHVLPDLEFLEKKYK-DMPFTVVGVHSAKFDNEKDLDAIRNAVLRYDISHPVV 486

  Fly   149 NDSRSGMWRALGIRCWPSLLILSPTGVPMMLLMGEGHGKFLQDFFSSALSYFSRQGIIDHRGLPL 213
            ||....|||.|||..||:..::||.|..:..:.||||.|.|.|..::||:|:..:.::|...||.
plant   487 NDGDMYMWRELGINSWPTFAVVSPNGKVIAQIAGEGHRKDLDDVVAAALTYYGGKNVLDSTPLPT 551

  Fly   214 KLFNDFQP---ASNLRFPAKI-VQGPNGLYAIADTGNNRVLVLTAGG--VVQHRIGGHQPGFVDG 272
            :|..|..|   .|.|:||.|: :...|....|:|:.:||::|....|  :||....|.: ||.||
plant   552 RLEKDNDPRLATSPLKFPGKLAIDTLNNRLFISDSNHNRIIVTDLEGNFIVQIGSSGEE-GFQDG 615

  Fly   273 DLTVARFNNPQGIAF-LNENVLIVADTKNHAIRQISLTNAMVETLAGTGIQGNDRIGGRLGPLQP 336
            ....|.||.|||:|: ..:|:|.||||:|||:|:|...|..|:||||.|.:|:|..|||.|..|.
plant   616 SFEDAAFNRPQGLAYNAKKNLLYVADTENHALREIDFVNERVQTLAGNGTKGSDYQGGRKGTKQL 680

  Fly   337 LSSPWDVAIFRTRDMDMSFHLDERNIPEKTIILISMAGTHQIWGY-FPEGIIWWKFRKFEPCCCV 400
            |:|||||..              ..:.||  :.|:|||.||||.| ..:||.    |.|.
plant   681 LNSPWDVCF--------------EPVNEK--VYIAMAGQHQIWEYSVLDGIT----RVFS----- 720

  Fly   401 SLIGNGLEENRNNSYPQNAAFAQPSGLAIAGDV--LYIADSESSSIRKASMIDGKVMPVVGGDRN 463
               |||.|.|.|.|.||..:||||||:::..|:  .|||||||||||...:..|....:.|||
plant   721 ---GNGYERNLNGSTPQTTSFAQPSGISLGPDLKEAYIADSESSSIRALDLQTGGSRLLAGGD-- 780

  Fly   464 PL---NLFAFGDIDGRLFSAKLQHPLGV-TFNDTNNKLYVADTYNHKIKIIDIDSNDISTL---- 520
            |.   |||.|||.||......||||||| ..||  .::|:.|:||||||.:|..:..:.||
plant   781 PYFSENLFKFGDNDGVGAEVLLQHPLGVLCAND--GQIYLTDSYNHKIKKLDPVTKRVVTLAGTG 843

  Fly   521 -------QIKSQENTNLILNEPAGLCLDASGRNLLVADTNNHSIHTIDL--------VTLIAQ-- 568
                   ::|..:     |:|||||.:..:|| |.||||||..|..|||        :||..:
plant   844 KAGFKDGKVKGAQ-----LSEPAGLAITENGR-LFVADTNNSLIRYIDLNKGEDSEILTLELKGV 902

  Fly   569 ----PFGLDFRQIASASEIDAPQDTQKPTENNIVKALPLDLIKPSKIFFNLRLS--PRFNFTKEA 627
                |.....:::...:..|             .|.:.:|.:...:...||::|  ..::|:|||
plant   903 QPPTPKAKSLKRLRKRASAD-------------TKIVKVDSVTSREGDLNLKISLPDGYHFSKEA 954

  Fly   628 PQKWIVKTVCQ-SVIVNPTCGNLL-DG--MCHMQVQATRPDFMCESSQIFTIEFVLNLCLSN-CC 687
            ..|::|....: :|.::||.|.|. :|  |.|....:|       |:.:..|...:..|..: .|
plant   955 RSKFVVDVEPENAVAIDPTEGTLSPEGSTMLHFIQSST-------SASVGKISCKVYYCKEDEVC 1012

  Fly   688 LVKKITVSI 696
            |.:.:...:
plant  1013 LYQSVQFEV 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12547	NP_001036460.1	TlpA_like_DipZ_like	58..184	CDD:239310	63/126 (50%)
		NHL	<205..306	CDD:302697	42/107 (39%)
		NHL repeat	227..271	CDD:271320	15/46 (33%)
		NHL-2_like	262..618	CDD:271321	146/388 (38%)
		NHL repeat	280..306	CDD:271320	15/26 (58%)
		NHL repeat	282..324	CDD:271321	22/42 (52%)
		NHL repeat	340..407	CDD:271321	21/67 (31%)
		NHL repeat	424..470	CDD:271321	23/50 (46%)
		NHL repeat	482..523	CDD:271321	20/52 (38%)
		NHL repeat	534..569	CDD:271321	20/48 (42%)
AT1G56500	NP_564718.2	PLN02919	1..1055	CDD:215497	267/724 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	117	1.000	Domainoid score	I1961
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12048
Inparanoid	1	1.050	369	1.000	Inparanoid score	I569
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1145834at2759
OrthoFinder	1	1.000	-	-		FOG0006210
OrthoInspector	1	1.000	-	-		oto4265
orthoMCL	1	0.900	-	-		OOG6_104506
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4487
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830