DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12547 and NHLRC2

DIOPT Version :9

Sequence 1:	NP_001036460.1	Gene:	CG12547 / 3355145	FlyBaseID:	FBgn0250830	Length:	717	Species:	Drosophila melanogaster
Sequence 2:	NP_940916.2	Gene:	NHLRC2 / 374354	HGNCID:	24731	Length:	726	Species:	Homo sapiens

Alignment Length:	737	Identity:	286/737 - (38%)
Similarity:	405/737 - (54%)	Gaps:	108/737 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ENEKAGTIVKFL---DRWNDDISIAKLKDLTVEFESDLEWFNVSCPLSI-KGLQGKVIILDFFTY 90
            :.||...:.::|   |.|..|:|:.       ||...|||.|...|:|: |.|.||:::||||||
Human    31 QQEKDSLVYQYLQKVDGWEQDLSVP-------EFPEGLEWLNTEEPISVYKDLCGKIVVLDFFTY 88

  Fly    91 CCINCMHVLQELHLLEERFPIESGVVVIGVHSPKFENERNAANILSAVQRYGISHPIVNDSRSGM 155
            |||||:|:|.:||.||..:..:.|:::|||||.||.||:...||.|||.||.|:||:|||:.:.:
Human    89 CCINCIHLLPDLHALEHTYSDKDGLLIIGVHSAKFPNEKVLDNIKSAVLRYNITHPMVNDADASL 153

  Fly   156 WRALGIRCWPSLLILSPTGVPMMLLMGEGHGKFLQDFFSSALSYFSRQGIIDHRGLPLKLFNDFQ 220
            |:.|.:.|||:|:||.|.|..:..|:||||...|..:.|.||.|:..:|.|....:.:||:.|..
Human   154 WQELEVSCWPTLVILGPRGNMLFSLIGEGHKDKLFLYTSIALKYYKDRGQIRDNKIGIKLYKDSL 218

  Fly   221 PASNLRFPAKI-VQGPNGLYAIADTGNNRVLVLTAGGVVQHRIGGHQPGFVDGDLTVARFNNPQG 284
            |.|.|.||.|: |........|||||::|:||:...|.:|:.|||..||..||..:.:.||:|||
Human   219 PPSPLLFPGKVTVDQVTDRLVIADTGHHRILVVWKNGQIQYSIGGPNPGRKDGIFSESTFNSPQG 283

  Fly   285 IAFLNENVLIVADTKNHAIRQISLTNAMVETLAGTGIQGNDRIGGRLGPLQPLSSPWDVAIFRTR 349
            :|.:| |::.||||:||.||:|.|....|.|:||.||||.|:.||..|..||:|||||| :|.|.
Human   284 VAIMN-NIIYVADTENHLIRKIDLEAEKVSTVAGIGIQGTDKEGGAKGEQQPISSPWDV-VFGTS 346

  Fly   350 DMDMSFHLDERNIPEKTIILISMAGTHQIW------GYFPEGIIWWKFRKFEPCCCVSLIGNGLE 408
            ..:         :....|:.|:||||||||      |..|      |..:.....|:...|:|.|
Human   347 GSE---------VQRGDILWIAMAGTHQIWALLLDSGKLP------KKNELTKGTCLRFAGSGNE 396

  Fly   409 ENRNNSYPQNAAFAQPSGLAIAGD----VLYIADSESSSIRKASMIDGKVMPVVGGDRNPLNLFA 469
            |||||:||..|.|||||||::|.:    .|::||||||::|..|:.||.|..:|||:|:|:||||
Human   397 ENRNNAYPHKAGFAQPSGLSLASEDPWSCLFVADSESSTVRTVSLKDGAVKHLVGGERDPMNLFA 461

  Fly   470 FGDIDGRLFSAKLQHPLGVTFNDTNNKLYVADTYNHKIKIIDIDSNDISTL-------QIKSQEN 527
            |||:||...:||||||||||::...|.|||||:||||||::|..:.:.:||       .:.|...
Human   462 FGDVDGVGINAKLQHPLGVTWDKKRNLLYVADSYNHKIKVVDPKTKNCTTLAGTGDTNNVTSSSF 526

  Fly   528 TNLILNEPAGLCLDASGRNLLVADTNNHSIHTIDLVTLIAQPFGLDFRQIASASEIDAPQDTQKP 592
            |....|||.|||:..:|..|.|||||||.|..:||.|.:.....: ||  :..:.:|.|...:|.
Human   527 TESTFNEPGGLCIGENGELLYVADTNNHQIKVMDLETKMVSVLPI-FR--SENAVVDGPFLVEKQ 588

  Fly   593 TENNIVKALPLDLIKPSKIFFNLRLSP---------RFNFTKEAP-------------------Q 629
                  |.||    |..|...::||||         :|....:.|                   .
Human   589 ------KTLP----KLPKSAPSIRLSPVTACAGQTLQFKLRLDLPSGSKLTEGVSSCWFLTAEGN 643

  Fly   630 KWIVKTV-----CQSVIVNPTCGNLLDGMCHMQVQATRPDFMCESSQIFTIEFVLNLCL--SNCC 687
            :|:::..     .:::...||..        :|:    ||.......|.::...|..|.  |:.|
Human   644 EWLLQGQIAAGDIENISSQPTIS--------LQI----PDDCLSLEAIVSVSVFLYYCSADSSAC 696

  Fly   688 LVKKITVS--IKRDDIQEEYIS 707
            ::|.|..|  ::..|.|:..|:
Human   697 MMKAILFSQPLQITDTQQGCIA 718

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12547	NP_001036460.1	TlpA_like_DipZ_like	58..184	CDD:239310	64/126 (51%)
		NHL	<205..306	CDD:302697	44/101 (44%)
		NHL repeat	227..271	CDD:271320	19/44 (43%)
		NHL-2_like	262..618	CDD:271321	163/372 (44%)
		NHL repeat	280..306	CDD:271320	15/25 (60%)
		NHL repeat	282..324	CDD:271321	23/41 (56%)
		NHL repeat	340..407	CDD:271321	21/72 (29%)
		NHL repeat	424..470	CDD:271321	25/49 (51%)
		NHL repeat	482..523	CDD:271321	23/47 (49%)
		NHL repeat	534..569	CDD:271321	18/34 (53%)
NHLRC2	NP_940916.2	TlpA_like_DipZ_like	55..182	CDD:239310	64/133 (48%)
		NHL 1	212..254		18/41 (44%)
		NHL-2_like	261..624	CDD:271321	167/392 (43%)
		NHL 2	265..307		21/42 (50%)
		NHL repeat	281..322	CDD:271321	23/41 (56%)
		NHL 3	335..369		18/43 (42%)
		NHL repeat	338..395	CDD:271321	21/72 (29%)
		NHL 4	409..439		16/29 (55%)
		NHL repeat	412..462	CDD:271321	25/49 (51%)
		NHL 5	461..505		29/43 (67%)
		NHL repeat	474..515	CDD:271321	23/40 (58%)
		NHL 6	518..562		19/43 (44%)
		NHL repeat	533..568	CDD:271321	18/34 (53%)
		NHL repeat	581..624	CDD:271321	12/52 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141483
Domainoid	1	1.000	149	1.000	Domainoid score	I4455
eggNOG	1	0.900	-	-		E33208_3BJB0
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12048
Inparanoid	1	1.050	468	1.000	Inparanoid score	I1540
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49747
OrthoDB	1	1.010	-	-		D1145834at2759
OrthoFinder	1	1.000	-	-		FOG0006210
OrthoInspector	1	1.000	-	-		oto91019
orthoMCL	1	0.900	-	-		OOG6_104506
Panther	1	1.100	-	-	LDO	PTHR46388
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5866
SonicParanoid	1	1.000	-	-		X4487
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800