Protein Alignment CG12547 and LOC1275334

DIOPT Version :10

• Sequence 1: NP_001036460.1
• Gene: CG12547 / 3355145
• FlyBaseID: FBgn0250830
• Length: 717
• Species: Drosophila melanogaster
• Sequence 2: XP_314572.5
• Gene: LOC1275334 / 1275334
• VectorBaseID: AGAMI1_011511
• Length: 821
• Species: Anopheles gambiae
• Alignment Length: 754
• Identity: 327/754 - (43%)
• Similarity: 462/754 - (61%)
• Gaps: 58/754 - (7%)

  Fly    10 IDILTFITDEL---LQAYKSSKGENEK-AGTIVKFLDRWNDDISIAKLKDLTVEFESDLEWFNVS 70
            :::|...:::|   |.|..|:.|..:| ....:|..||..        |.:|.||...|:||||:
Mosquito    79 MEVLACNSNQLAEDLYAAGSNAGRRQKLVHDYLKVADRDG--------KSVTAEFPDGLDWFNVT 135

  Fly    71 CPLSIKG-LQGKVIILDFFTYCCINCMHVLQELHLLEERFPIESGVVVIGVHSPKFENERNAANI 134
            .||:::| |:|||::|||||||||||||:|..|..||..:|||.|:.|:||||.||.||:::|||
Mosquito   136 EPLTLQGSLRGKVVVLDFFTYCCINCMHILPNLKRLEHLYPIEEGLAVVGVHSAKFRNEKDSANI 200

  Fly   135 LSAVQRYGISHPIVNDSRSGMWRALGIRCWPSLLILSPTGVPMMLLMGEGHGKFLQDFFSSALSY 199
            .:||:||.||||:|||:.|.|||.|.::|||:|:||.|...|:.::||||:.:.|:.:..||:.:
Mosquito   201 RAAVERYEISHPVVNDNVSAMWRKLRVQCWPTLMILGPRANPLFVIMGEGNYEDLKLYVGSAIRF 265

  Fly   200 FSRQGIIDHRGLPLKLFNDFQPASNLRFPAKIV----QGPNG----LYAIADTGNNRVLVLTAGG 256
            :..:|.|....||:.|.:....|||:::|.|:.    .|..|    |:|::|:||:|||::.:.|
Mosquito   266 YREKGEIKRHSLPINLVSSGAIASNMKYPGKVACSVPTGAGGSEEQLFAVSDSGNHRVLIVNSAG 330

  Fly   257 VVQHRIGGHQPGFVDGDLTVARFNNPQGIAFLNENVLIVADTKNHAIRQISLTNAMVETLAGTGI 321
            .|.|::||.|.|||||:.|.||||.|||:||...:|:.|||.:|||:|:|.|...:|.|:||.|.
Mosquito   331 TVLHKVGGKQSGFVDGNFTKARFNAPQGVAFQGTDVVFVADNENHAVRRIDLKARLVSTIAGNGT 395

  Fly   322 QGNDRIGGRLGPLQPLSSPWDVAIFRTRDMDMSFHLDERNI-PEKTIILISMAGTHQIWGYFPEG 385
            |||||.||::|..|.||||||||::.|||:|||||.||.:. |.|.::||:|||.||||..|.:.
Mosquito   396 QGNDRTGGKVGREQLLSSPWDVAVYSTRDLDMSFHADEASAPPSKDVLLIAMAGIHQIWALFLQD 460

  Fly   386 IIWWKFRKFEPCCCVSLIGNGLEENRNNSYPQNAAFAQPSGLAI--AGDVLYIADSESSSIRKAS 448
            .|||||:|:....|.::.|||.|:|||.||||:|||||||||||  ....:|:||||||:|||.|
Mosquito   461 TIWWKFKKYGAGTCWAIAGNGHEQNRNTSYPQSAAFAQPSGLAINRTAKEVYLADSESSAIRKIS 525

  Fly   449 MIDGKVMPVVGGDRNPLNLFAFGDIDGRLFSAKLQHPLGVTFNDTNNKLYVADTYNHKIKIIDID 513
            :.|||||.|.|||||||:||||||:||:.:.||.||||||.:|..:..:|.|||||||||.||..
Mosquito   526 LADGKVMAVAGGDRNPLDLFAFGDVDGKQYGAKFQHPLGVAYNPQDGFIYFADTYNHKIKKIDAA 590

  Fly   514 SNDISTLQIKSQENTNLILNEPAGLCLDASGRNLLVADTNNHSIHTIDLVTLIAQPFGLDFRQIA 578
            :|..:|.:.:.........|||||||||.||:.|.:||||||.:...:|.....:|..|:||...
Mosquito   591 TNCATTCEFREANGAVRRFNEPAGLCLDRSGQLLYIADTNNHELLVANLTDCTIRPLKLNFRVPE 655

  Fly   579 SASEI--DAPQDTQKPTENNIVKALPLDLIKPSKIFFNLRLSPRFNF-------TKEAPQKWIVK 634
            ....:  :|.|..::.....:..|.|:.: .|:....:|||:..|.|       |:.|||:|.::
Mosquito   656 ELDSVAGEAEQGGRRSGTLTLKPARPITM-HPNAGQSSLRLTFNFTFPEQTTKLTEGAPQQWSLE 719

  Fly   635 TVCQSVIVNPTCGNLLDGMCHMQV------QATRPDFMCESSQIFTIEFVLNLCLSNCCLVKKIT 693
            ........:.|.|.:......:.:      .||..:   |.|....:.|.||||..:.|..|:..
Mosquito   720 LPAGGWSCDSTKGTIDTKTLQLLIALPPGNDATNGN---EPSNPVALTFKLNLCEGDICFPKEFV 781

  Fly   694 V--------------SIKRDDIQEEY-ISIHNVNIDIEQ 717
            |              ::.|.|.||.| :.:....:.::|
Mosquito   782 VLLEVQYSASEAGHPNVDRYDAQETYELQLSRKTVALQQ 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12547	NP_001036460.1	TlpA_like_DipZ_like	58..184	CDD:239310	73/126 (58%)
		NHL	<205..306	CDD:302697	48/108 (44%)
		NHL repeat	227..271	CDD:271320	20/51 (39%)
		NHL-2_like	262..618	CDD:271321	186/360 (52%)
		NHL repeat	280..306	CDD:271320	14/25 (56%)
		NHL repeat	282..324	CDD:271321	21/41 (51%)
		NHL repeat	340..407	CDD:271321	36/67 (54%)
		NHL repeat	424..470	CDD:271321	32/47 (68%)
		NHL repeat	482..523	CDD:271321	21/40 (53%)
		NHL repeat	534..569	CDD:271321	18/34 (53%)
LOC1275334	XP_314572.5	None