DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and PKP4

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_001364147.1	Gene:	PKP4 / 8502	HGNCID:	9026	Length:	1192	Species:	Homo sapiens

Alignment Length:	837	Identity:	315/837 - (37%)
Similarity:	425/837 - (50%)	Gaps:	185/837 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KHSLIGLNMNSTHINMDLSLT--HEPANMQSQFGSFQNYDQFSAAGYSSTPLYITKPTGVGAITK 69
            :||.:|.::.|. ::.||.:|  :|.....|......|:......| |.|.||.|...|:|.:.:
Human   393 QHSQLGQDLRSA-VSPDLHITPIYEGRTYYSPVYRSPNHGTVELQG-SQTALYRTGSVGIGNLQR 455

  Fly    70 VAPHCSQNKIETNSTDNSIPDIENHPLATTVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEAVVP 134
            .:...|....:.|          |:.|.||..|                          ||...|
Human   456 TSSQRSTLTYQRN----------NYALNTTATY--------------------------AEPYRP 484

  Fly   135 YCY-TSDANYTGIQNTTSSIKPFSGRPFNDNINGAEAVADSQCRTFKSSAEFKLPQFAMSSINTV 198
            ..| ..:.||..:|:..         |.:|....:.::...|    |...||
Human   485 IQYRVQECNYNRLQHAV---------PADDGTTRSPSIDSIQ----KDPREF------------- 523

  Fly   199 PQRLEEKDDYIEGSENDICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRT 263
                                  .||||.|.|||..|.:...:::|||||||||||:.|:..|...
Human   524 ----------------------AWRDPELPEVIHMLQHQFPSVQANAAAYLQHLCFGDNKVKMEV 566

  Fly   264 RSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEV 328
            ..||||..||.||.:...|:.||||||||||.:|:..||||..:||.|||.||:.||.:|.:.||
Human   567 CRLGGIKHLVDLLDHRVLEVQKNACGALRNLVFGKSTDENKIAMKNVGGIPALLRLLRKSIDAEV 631

  Fly   329 KELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGWDAVCCGETCF----------STVFR 383
            :|||||||||:|||:.:|.:||.:||..:..:||.|||||:     .:.|          |.|.|
Human   632 RELVTGVLWNLSSCDAVKMTIIRDALSTLTNTVIVPHSGWN-----NSSFDDDHKIKFQTSLVLR 691

  Fly   384 NASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQ-- 446
            |.:|.|||:|||||.||..:|:||.||:.||||:.|.:..::..:||||||||.|||||||.:
Human   692 NTTGCLRNLSSAGEEARKQMRSCEGLVDSLLYVIHTCVNTSDYDSKTVENCVCTLRNLSYRLELE 756

  Fly   447 ----------EVDD------PNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEAN-NSDALNE 494
                      |:||      |:.|..|                 .|:|..||||:.. ..|..:.
Human   757 VPQARLLGLNELDDLLGKESPSKDSEP-----------------SCWGKKKKKKKRTPQEDQWDG 804

  Fly   495 YNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSI 559
            .......|||.       ||.|.||.|.||:.||:||...|||.|||.:||::|||||..|:.:.
Human   805 VGPIPGLSKSP-------KGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQNLSAGNWKFAA 862

  Fly   560 DIRATVRKEKGLPILVELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQ 624
            .|||.||||||||||||||||:.||||.:|||||||:|:|.|||||||||||||||.:||.||
Human   863 YIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDLVNRLPGGN-- 925

  Fly   625 HDQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITK-RKEKYTSCVLKFASQVLYT 688
            .....||:|:.|:...::||..||.|.:::|.|||||::|:|||| |.::.:..|:|.|:|||.|
Human   926 GPSVLSDETMAAICCALHEVTSKNMENAKALADSGGIEKLVNITKGRGDRSSLKVVKAAAQVLNT 990

  Fly   689 MWQHNELRDVYKKNGWKEQDFVS-------KHFTAHNTPPSSPNN---------VNNTLNRPMAS 737
            :||:.:||.:|||:||.:..|::       ..|.:|  |..|..|         |.:|.:.| |.
Human   991 LWQYRDLRSIYKKDGWNQNHFITPVSTLERDRFKSH--PSLSTTNQQMSPIIQSVGSTSSSP-AL 1052

  Fly   738 QG----RTRYEDRT-------IQRGTST---LYSANDSSGAV-MSNESAMLSEMVRK 779
            .|    |:.| |||       ..:|.:|   ||..:.....: :|:.|:...|..|:
Human  1053 LGIRDPRSEY-DRTQPPMQYYNSQGDATHKGLYPGSSKPSPIYISSYSSPAREQNRR 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	63/113 (56%)
		armadillo repeat	227..252	CDD:293788	13/24 (54%)
		armadillo repeat	260..296	CDD:293788	20/35 (57%)
		armadillo repeat	304..339	CDD:293788	21/34 (62%)
		ARM	307..442	CDD:237987	73/144 (51%)
		armadillo repeat	347..392	CDD:293788	19/54 (35%)
		armadillo repeat	515..556	CDD:293788	23/40 (58%)
		ARM	516..643	CDD:237987	79/126 (63%)
		armadillo repeat	562..596	CDD:293788	28/33 (85%)
		armadillo repeat	601..641	CDD:293788	23/39 (59%)
PKP4	NP_001364147.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	73..262
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..310
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	323..348
		ARM 1	415..455		11/40 (28%)
		ARM 2	518..557		22/73 (30%)
		ARM 3	560..599		20/38 (53%)
		ARM 4	604..644		25/39 (64%)
		ARM 5	660..702		16/46 (35%)
		ARM 6	706..751		24/44 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	773..810		10/53 (19%)
		ARM 7	815..855		23/46 (50%)
		ARM 8	862..901		30/38 (79%)
		ARM 9	950..993		20/42 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1058..1086		9/28 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5321
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1931
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41407
orthoMCL	1	0.900	-	-		OOG6_104813
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	1	1.000	-	-		X765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.900