DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and odad2

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_005156286.1	Gene:	odad2 / 799229	ZFINID:	ZDB-GENE-100316-7	Length:	1047	Species:	Danio rerio

Alignment Length:	724	Identity:	151/724 - (20%)
Similarity:	254/724 - (35%)	Gaps:	240/724 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 IENHPLATTVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEAVVPYCYTSD-------ANYTGIQN 148
            |::.|.|..:.:|::                 :|:|.|.:.:.|  |.|:       |....:||
Zfish   303 IQDVPSAKKILHVES-----------------VDAEKTGQTLKP--YNSEEKNVLKKARQQPVQN 348

  Fly   149 TTSSIK-----------------------------------------PFSGRPFNDNINGAEAVA 172
            ...:.|                                         |.|......||:|
Zfish   349 KLGNRKKKLEPSLKWKNLGLTSPYDEGEVKARKIRESKKIFEYGTKSPTSESKKKTNISG----- 408

  Fly   173 DSQCRTFKSSAEFKLPQFAMSSINTVPQRLEEKDDYIEGSE--NDICSTMRWRDPNLSEVISFLS 235
             |.....:||.:.|.|..|.....:..:..|:::.:...:|  .|:.|.. |:   :.:::.:|.
Zfish   409 -SSLPGLQSSQKIKTPGGAEDFSESSSEEEEDEEQHERRAETATDLPSEY-WQ---IQKLVKYLK 468

  Fly   236 NPSSAIKANAAAYLQHLCYMDDPN------KQRTRSLGGIPPLVRLLSYDSPEIHKNAC--GALR 292
            .      ||..|.:..||.:.|.|      :...|.:||:..|:.||  |:.||.   |  |:|:
Zfish   469 G------ANQTATVIVLCSLRDFNLVQDTCQLAIRDVGGLEVLINLL--DTDEIR---CKIGSLK 522

  Fly   293 NLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAV 357
            .|.....|.:.:|.|.|.||:..:|.:| .|.:.|:|.|....:.|::.....:|
Zfish   523 ILKEISCNSQIRRTIANLGGLQTMVSIL-DSPDKELKCLAAETIANVAKFRRARR---------- 576

  Fly   358 VCSVIKPHSG-------WDAVCCGE---------------------TCFSTVF-----RNASGVL 389
               :::.|.|       .|.|..||                     :|..:.:     |.|.|:.
Zfish   577 ---MVRQHGGIQRLVELLDCVPAGESLSLEQQRDVEVARCGALALWSCSKSTWNKEAIRRAGGIP 638

  Fly   390 ---RNVSSAGEH----ARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLS----- 442
               |.:.|..::    ..|.|:.|.....     .|.:|:...:....|:|..|..:.|.
Zfish   639 MLGRLLKSPQKNMLIPVVGTLQECASEKS-----YRIAIQAEGMIEDLVKNLSCDNQELQMHCAS 698

  Fly   443 --YRCQEVDDPNYDKH------------PFITPERVIPSSSKGENLGCFGTNKKKKEANNSDALN 493
              ::|.|      |||            |.:|      ..::.||        |:..|..:.|:
Zfish   699 AIFKCAE------DKHTRDLVRQYDGLKPLVT------LLNEAEN--------KQLLAATTGAI- 742

  Fly   494 EYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPS 558
                    .|.|::...:.|..|.    :||:..:.||  .:.||  |.....:..|..| .|.|
Zfish   743 --------WKCSISMENVAKFQEY----KVVEILVRLL--TNQPE--EVLVNVVGALGEC-GQIS 790

  Fly   559 IDIRATVRKEKGLPILVELLR-------MEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQ 616
            .:: ||:|:..|:..||.||.       :.|.:.|.|.||...|:.|..|   |.|...:..|:
Zfish   791 ENL-ATIRRSSGIQPLVNLLTGTNQALLVNVTKAVGACATDPENMMIIDR---LDGVRLLWSLL- 850

  Fly   617 KLPSGNVQHDQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRKEK-----YTS 676
            |.|:..||      .....|:...| |..|...|..||.:  ||::.::|:.|.:.|     ..:
Zfish   851 KNPNPEVQ------ASAAWAICPCI-ENAKDAGEMVRSFV--GGLELIVNLLKSQNKDVLASVCA 906

  Fly   677 CVLKFASQV 685
            .:.|.|..|
Zfish   907 AIAKIAKDV 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	34/121 (28%)
		armadillo repeat	227..252	CDD:293788	4/24 (17%)
		armadillo repeat	260..296	CDD:293788	13/37 (35%)
		armadillo repeat	304..339	CDD:293788	11/34 (32%)
		ARM	307..442	CDD:237987	32/174 (18%)
		armadillo repeat	347..392	CDD:293788	12/80 (15%)
		armadillo repeat	515..556	CDD:293788	10/40 (25%)
		ARM	516..643	CDD:237987	37/133 (28%)
		armadillo repeat	562..596	CDD:293788	13/40 (33%)
		armadillo repeat	601..641	CDD:293788	9/39 (23%)
odad2	XP_005156286.1	armadillo repeat	460..487	CDD:293788	7/32 (22%)
		armadillo repeat	495..527	CDD:293788	13/36 (36%)
		armadillo repeat	543..568	CDD:293788	6/25 (24%)
		armadillo repeat	576..623	CDD:293788	8/59 (14%)
		armadillo repeat	628..659	CDD:293788	6/30 (20%)
		Arm_3	<634..>865	CDD:330530	63/284 (22%)
		armadillo repeat	669..701	CDD:293788	6/31 (19%)
		armadillo repeat	713..744	CDD:293788	7/53 (13%)
		armadillo repeat	761..785	CDD:293788	7/27 (26%)
		armadillo repeat	793..829	CDD:293788	11/36 (31%)
		armadillo repeat	834..866	CDD:293788	10/41 (24%)
		HEAT_2	845..950	CDD:316194	20/81 (25%)
		armadillo repeat	876..908	CDD:293788	8/33 (24%)
		HEAT repeat	923..961	CDD:293787
		HEAT repeat	970..992	CDD:293787
		HEAT repeat	1005..1034	CDD:293787
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030