DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and pkp4

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_012826046.1	Gene:	pkp4 / 780351	XenbaseID:	XB-GENE-489870	Length:	1195	Species:	Xenopus tropicalis

Alignment Length:	788	Identity:	300/788 - (38%)
Similarity:	422/788 - (53%)	Gaps:	118/788 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 HSLIGLN----MNSTHINMDLSLTHEPANMQSQFGSFQNYDQFSAAGYSSTPLY----ITKPTGV 64
            ||.:|.:    |.|:.......:|..|.:|.:...:..:.||:   |.....:|    ..:|..:
Frog   325 HSRVGSSSQTPMGSSSSPKRAGMTAVPQHMGTLQRNLHDIDQY---GQQHFDIYERMVPPRPDSL 386

  Fly    65 -GAITKVAPHCSQNKIETNSTDNSIPDIENHPLATTVRYVQAGQYEDTSEYGVA---GLTCGIDS 125
             |..:..|...||...|..|..:  ||::..|:           ||..:.|...   .....|:.
Frog   387 TGLRSSYASQHSQLGQELRSAVS--PDLQITPI-----------YEGRTYYSPVYRNANHAAIEL 438

  Fly   126 EYTAEAVVPYCYTSDANYTGIQNTTSSIKPFSGRPFNDNINGAEAVADSQCRTFKSSAEFKLPQF 190
            ...:...:   |.:.:..:.:|.|.|.....:.:..|..:|.|...|:          .::..|:
Frog   439 RQGSNTAI---YRTGSGSSNLQRTMSQRSTLAYQRNNYALNSAANYAE----------PYRSMQY 490

  Fly   191 AMS--SINTVPQRLEEKD--------DYIEGSENDICSTMRWRDPNLSEVISFLSNPSSAIKANA 245
            .:|  ..|.:|......|        |.|:....:..    ||||.|.|||..|.:...:::|||
Frog   491 RISEPGYNRMPHSAPPDDGTTRSPSIDSIQKDPREFA----WRDPELPEVIHMLQHHFPSVQANA 551

  Fly   246 AAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNA 310
            ||||||||:.|...|.....||||..||.||.....|:.||||||||||.||:..||||..:|||
Frog   552 AAYLQHLCFGDHKTKIEVCRLGGIKHLVDLLDNKVLEVQKNACGALRNLVYGKSTDENKVAVKNA 616

  Fly   311 GGIAALVHLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGWDAVCCGE 375
            ||:.||:.||.::.:.||:|||||||||:|||:.:|.:||.:||..:..:||.||||::     .
Frog   617 GGVPALLRLLRKTNDQEVRELVTGVLWNLSSCDAVKMTIIRDALSPLTNTVIVPHSGFN-----N 676

  Fly   376 TCF----------STVFRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKT 430
            :.|          |:|.||.:|.:||:|||||.||..:|.||.||:.||:|::|.:..::..:||
Frog   677 SSFDDDHKMKFQSSSVLRNTTGCMRNLSSAGEEARKQMRYCEGLVDSLLFVIQTCVNTSDFDSKT 741

  Fly   431 VENCVCILRNLSYRCQEVDDPNYDKHPFITPERVI----------PSSSKGENLGCFG-TNKKKK 484
            ||||||.|||||||. |::.|.         .|::          .|.||..:..|:| ..||||
Frog   742 VENCVCTLRNLSYRL-ELEVPQ---------ARMLGINEMDGFCKESPSKESDSSCWGKKKKKKK 796

  Fly   485 EANNSDALNEYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQN 549
            :....|..:........|:|.       ||.|.||.|.||:.||:||...|||.|||.:||::||
Frog   797 KPPQEDLWDGVGPIPGLSQSP-------KGVEMLWHPSVVKPYLTLLAESSNPATLEGSAGSLQN 854

  Fly   550 LSACYWQPSIDIRATVRKEKGLPILVELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDL 614
            |||..|:.:..|||.||||||||||||||||:.||||.:|||||||:|:|.||||||||||||||
Frog   855 LSAGNWKFAAYIRAAVRKEKGLPILVELLRMDNDRVVSSVATALRNMALDVRNKELIGKYAMRDL 919

  Fly   615 VQKLPSGN---VQHDQNTSDDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRKEKYTS 676
            |.:||.||   |     .||||:.|:...::||..||.|.:::|.|:|||::|:||||.|...:|
Frog   920 VNRLPGGNGPCV-----LSDDTVAAICCALHEVTSKNMENAKALADTGGIEKLVNITKGKGDRSS 979

  Fly   677 C-VLKFASQVLYTMWQHNELRDVYKKNGWKEQDFVS-------KHFTAHNTPPSSPNNVNNTLNR 733
            . |:|.|:|||.|:||:.:||.:|||:||.:..|::       :.|.:|    .|.:..|..::.
Frog   980 LKVVKAAAQVLNTLWQYRDLRSIYKKDGWNQSHFITPVSTLERERFKSH----PSLSTTNQQMSP 1040

  Fly   734 PMASQGRT 741
            .:.|.|.|
Frog  1041 MIQSVGST 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	63/113 (56%)
		armadillo repeat	227..252	CDD:293788	13/24 (54%)
		armadillo repeat	260..296	CDD:293788	20/35 (57%)
		armadillo repeat	304..339	CDD:293788	20/34 (59%)
		ARM	307..442	CDD:237987	69/144 (48%)
		armadillo repeat	347..392	CDD:293788	17/54 (31%)
		armadillo repeat	515..556	CDD:293788	23/40 (58%)
		ARM	516..643	CDD:237987	81/129 (63%)
		armadillo repeat	562..596	CDD:293788	28/33 (85%)
		armadillo repeat	601..641	CDD:293788	25/42 (60%)
pkp4	XP_012826046.1	ARM	525..647	CDD:237987	67/125 (54%)
		HEAT_2	533..636	CDD:290374	54/102 (53%)
		armadillo repeat	533..558	CDD:293788	13/24 (54%)
		armadillo repeat	566..602	CDD:293788	20/35 (57%)
		armadillo repeat	610..645	CDD:293788	20/34 (59%)
		armadillo repeat	652..703	CDD:293788	18/55 (33%)
		ARM	683..>770	CDD:237987	41/96 (43%)
		armadillo repeat	711..752	CDD:293788	20/40 (50%)
		armadillo repeat	820..857	CDD:293788	21/36 (58%)
		ARM	821..949	CDD:237987	83/132 (63%)
		armadillo repeat	869..901	CDD:293788	26/31 (84%)
		armadillo repeat	908..949	CDD:293788	25/45 (56%)
		armadillo repeat	955..990	CDD:293788	16/34 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	110	1.000	Domainoid score	I6210
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1705
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48613
Panther	1	1.100	-	-	O	PTHR10372
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.160