DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and armc3

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_688618.3	Gene:	armc3 / 560136	ZFINID:	ZDB-GENE-110614-1	Length:	831	Species:	Danio rerio

Alignment Length:	704	Identity:	142/704 - (20%)
Similarity:	236/704 - (33%)	Gaps:	226/704 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 EGSENDICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVR 274
            |....|:...:.......:..:..||:|...:.|.|...:.......|.||.....||.|.||..
Zfish    10 ETCPKDVFDPLSIESKTATTAVLMLSSPEEEVLAKACEAIHKFAEKGDENKTCLMCLGAIEPLSL 74

  Fly   275 LLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNM 339
            |:|::...:.:||..||..::   .|:|.|:.:|....|.|::..|...:...|.|..|..|.::
Zfish    75 LISHEDKIVRRNAVMALGVMA---SNNEVKKHLKCLDVIPAIISKLSPEENVMVHEFATLCLASL 136

  Fly   340 SSCEDLKRSIID----EALV-------------AVVC---------------------------- 359
            |.....|..|.:    |.|:             :|.|
Zfish   137 SVDFSYKIQIFESNGLEPLIQLLSSPDPDVKKNSVECIFNLVQDVQNRAAVQRLNGLPPLLDLLR 201

  Fly   360 ---SVIKP---HSGWDAVCCGETCFSTVFRNASG--------VLRNVSSAGEHARGCLRNC---- 406
               |||:.   |:........|||  ..|||..|        .::..|...|.|...:.||
Zfish   202 SEFSVIQQLALHTIEKITTDTETC--VAFRNVQGFERILEVVAMKEFSDLHEGALRVILNCLEDT 264

  Fly   407 ------------EHLVECLLYVVRTS-------------------------IEKNNI-------- 426
                        |.|::|    |.||                         :.:.||
Zfish   265 ESMQLFQTMGGLEQLLQC----VGTSTVAEVKANAVKAIAKMAQSSENRKILHERNIEKTLTDLL 325

  Fly   427 --GNKTVENCVC-----ILRNLSYRCQEVDDPNYDKHPFITPERVIP----SSSKGENLGCFGTN 480
              .|::|...||     :.:|||.|           ..|.:.:.:.|    .:|:|..|. ....
Zfish   326 TQENESVRTAVCQAVATVSKNLSSR-----------DTFRSLDGIRPIVQLLNSEGSELR-MAAA 378

  Fly   481 KKKKEANNSDALNEYNISADYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAG 545
            :......||:.||.|.|                 |:......:|:   .|..||:.....  ||.
Zfish   379 EALSSLTNSNNLNAYAI-----------------YDAEGDRLLVR---QLQDSCTGAAVY--AAM 421

  Fly   546 AIQNLSACYWQPSIDIRATVRKEKGLPILVELLRMEVDRVVCAVATALRNLAID-QRNKELIGKY 609
            |:.|:::     ..::|.::...:.:|.|||||....:.::.:...|:.:|..| :..:||....
Zfish   422 ALTNMAS-----QEELRKSILAHEAMPALVELLHSTDNNILISAVQAVASLTCDAEARQELRNVG 481

  Fly   610 AMRDLVQKLPSGNVQHDQNTS-------DDTITA----------VLATINEVIKKNPEFS----R 653
            .:..|||.|.|.|.:..:|.|       :|.|||          :|..|:....::.:||    :
Zfish   482 GLSALVQLLKSINAEIRRNASWAISVCANDEITASELCNVGALEILQEISLSSHRSNKFSQLALQ 546

  Fly   654 SLLDSGGIDRLMNITKRKEKYTSCVLKFASQV----------LYTMWQHNELRDVYKK------- 701
            .||||       |::.   ||:......:|.:          :....|...|.|:.|:
Zfish   547 KLLDS-------NLSL---KYSLTGHLSSSDITTDGFYDPGQIRVGHQFPVLEDISKQVVNQHRA 601

  Fly   702 ----NGWKEQDFV------SKHFTAHNTPPSSPNNVNNTLNRPMASQGRTRYED 745
                ||..:..|:      .|..:..:|..||..|...:...|..::|:...|:
Zfish   602 TIAVNGKPQNQFIPKGPEEGKQDSPTDTTASSVLNGRRSSKTPSKTKGKGHKEE 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	30/113 (27%)
		armadillo repeat	227..252	CDD:293788	5/24 (21%)
		armadillo repeat	260..296	CDD:293788	12/35 (34%)
		armadillo repeat	304..339	CDD:293788	9/34 (26%)
		ARM	307..442	CDD:237987	44/249 (18%)
		armadillo repeat	347..392	CDD:293788	16/103 (16%)
		armadillo repeat	515..556	CDD:293788	9/40 (23%)
		ARM	516..643	CDD:237987	34/144 (24%)
		armadillo repeat	562..596	CDD:293788	8/33 (24%)
		armadillo repeat	601..641	CDD:293788	15/56 (27%)
armc3	XP_688618.3	ARM	31..179	CDD:237987	37/150 (25%)
		armadillo repeat	60..96	CDD:293788	12/38 (32%)
		ARM	108..220	CDD:237987	18/111 (16%)
		armadillo repeat	110..136	CDD:293788	7/25 (28%)
		armadillo repeat	144..179	CDD:293788	5/34 (15%)
		armadillo repeat	184..218	CDD:293788	4/33 (12%)
		ARM	268..385	CDD:237987	21/132 (16%)
		HEAT_2	276..382	CDD:290374	21/121 (17%)
		HEAT repeat	276..301	CDD:293787	6/28 (21%)
		HEAT repeat	317..345	CDD:293787	5/27 (19%)
		HEAT repeat	355..387	CDD:293787	4/32 (13%)
		ARM	394..506	CDD:237987	30/138 (22%)
		armadillo repeat	433..469	CDD:293788	9/35 (26%)
		armadillo repeat	474..506	CDD:293788	10/31 (32%)
		ARM	475..>554	CDD:237987	23/85 (27%)
		EDR1	553..817	CDD:291079	18/106 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940