DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and ctnnd2b

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_001352544.1	Gene:	ctnnd2b / 558069	ZFINID:	ZDB-GENE-070912-532	Length:	1229	Species:	Danio rerio

Alignment Length:	746	Identity:	303/746 - (40%)
Similarity:	427/746 - (57%)	Gaps:	116/746 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 SIPDIENHPLATTVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEAVVPY-----CYTSDANYTGI 146
            |.|.:::.||..|      |....|..:..||...|..:. ||:...||     |.::|:.|:
Zfish   440 SSPGVDSIPLQRT------GSQNATGTFPRAGYATGPGAS-TADYANPYRTLQFCPSTDSPYS-- 495

  Fly   147 QNTTSSIKPFSGRPFNDNINGAEAVADSQCRTFKSSAEFKLPQFAMSSINTVPQRLEEKDDYIEG 211
             .:..::.|           .|..|......:.:....:. |:|.:.:.|...||:.::
Zfish   496 -KSGPALPP-----------EATLVRSPSVDSIQKDPRYD-PEFLVWNQNQAEQRMTKE------ 541

  Fly   212 SENDICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLL 276
                    ..||||.|.|||..|.:...::::||||||||||:.|:..|...|..|||..||.||
Zfish   542 --------FGWRDPELPEVIQMLQHQFPSVQSNAAAYLQHLCFGDNKIKSEIRRQGGIQLLVDLL 598

  Fly   277 SYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSS 341
            .:...::|::||||||||.||:.||:||..:||.|||.|||.||.::.:.|::||:||||||:||
Zfish   599 DHRMTDVHRSACGALRNLVYGKANDDNKIALKNCGGIPALVRLLRKTTDVEIRELLTGVLWNLSS 663

  Fly   342 CEDLKRSIIDEALVAVVCSVIKPHSGWDAVCCGE-----TCFSTVFRNASGVLRNVSSAGEHARG 401
            |:.||..||.:||..:..:||.||||||.....:     ...|.|.|||:|.|||||||||.||.
Zfish   664 CDALKMPIIQDALAVLTNTVIIPHSGWDTSPLQDDRKLHLHSSQVLRNATGCLRNVSSAGEEARR 728

  Fly   402 CLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRC-------QEVDDPNYDKHPFI 459
            .:|.||.|.:.||||::|::..:.|.:||:|||||||||||||.       |::.....|
Zfish   729 RMRECEGLTDALLYVIQTALGTSEIDSKTIENCVCILRNLSYRLAAETSQGQQMGSEELD----- 788

  Fly   460 TPERVIPSSSKG---ENLGCFGTNKKKKEANNS-DALNEYNISADYSKSSVTYNKLNKGYEQLWQ 520
               .|:.:.:.|   |:.||:|..||||::::. |.:..:..|:|..          ||.:.||.
Zfish   789 ---GVLCTDASGKDAESSGCWGKKKKKKKSHDQWDGVGPFPDSSDPP----------KGLQMLWH 840

  Fly   521 PEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQP-------SIDIRATVRKEKGLPILVELL 578
            |.:|:.||:||..||||:|||.||||:|||:|..|:.       |:.|||.||||||||||||||
Zfish   841 PSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKVGPTLKPWSVYIRAAVRKEKGLPILVELL 905

  Fly   579 RMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQHDQNT-------SDDTITA 636
            |::.|||||||||||||:|:|.|||||||||||||||.:||.||..:...|       |||||||
Zfish   906 RIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGNNNNSTGTGGSSKSMSDDTITA 970

  Fly   637 VLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRK-EKYTSCVLKFASQVLYTMWQHNELRDVYK 700
            :...::|||.||.|.:::|.|:|||::|:.|.:.| :|:|..|:|.|||||.:|||:.:||.:||
Zfish   971 ICCALHEVITKNMENTKALRDAGGIEKLIGIARSKGDKHTPKVVKAASQVLNSMWQYRDLRSLYK 1035

  Fly   701 KNGWKEQDFV----------SKHFTAHNTPP-----SSPNNVN---NTLNRPMAS--QGRTRYED 745
            |:|:.:..||          .:.:::..||.     :||||.:   .|..|.|.|  :.:|.||
Zfish  1036 KDGYSQYHFVGSSSTIERDRQRPYSSSRTPSISPVRTSPNNRSASAPTSPREMMSLKERKTDYE- 1099

  Fly   746 RTIQRGTSTLYSANDSSGAVMSNESAMLSEM 776
               ..|:::.|..|  .|...|.:.||.:::
Zfish  1100 ---STGSNSTYHGN--KGEHTSRKDAMAAQI 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	59/113 (52%)
		armadillo repeat	227..252	CDD:293788	12/24 (50%)
		armadillo repeat	260..296	CDD:293788	18/35 (51%)
		armadillo repeat	304..339	CDD:293788	19/34 (56%)
		ARM	307..442	CDD:237987	74/139 (53%)
		armadillo repeat	347..392	CDD:293788	20/49 (41%)
		armadillo repeat	515..556	CDD:293788	23/40 (58%)
		ARM	516..643	CDD:237987	85/140 (61%)
		armadillo repeat	562..596	CDD:293788	29/33 (88%)
		armadillo repeat	601..641	CDD:293788	27/46 (59%)
ctnnd2b	NP_001352544.1	PLN03200	547..>720	CDD:331927	86/172 (50%)
		armadillo repeat	549..574	CDD:293788	12/24 (50%)
		ARM	578..618	CDD:214547	19/39 (49%)
		armadillo repeat	582..618	CDD:293788	18/35 (51%)
		ARM	622..663	CDD:214547	23/40 (58%)
		armadillo repeat	626..661	CDD:293788	19/34 (56%)
		armadillo repeat	668..719	CDD:293788	21/50 (42%)
		Arm	831..872	CDD:278915	24/50 (48%)
		armadillo repeat	835..872	CDD:293788	22/36 (61%)
		ARM	889..924	CDD:214547	30/34 (88%)
		armadillo repeat	889..923	CDD:293788	29/33 (88%)
		armadillo repeat	930..980	CDD:293788	27/49 (55%)
		armadillo repeat	986..1021	CDD:293788	15/34 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5526
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55574
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1698
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	1	1.000	-	-		FOG0006320
OrthoInspector	1	1.000	-	-		otm24726
orthoMCL	1	0.900	-	-		OOG6_104813
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	1	1.000	-	-		X765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.900