DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and ctnnd1

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_021332609.1	Gene:	ctnnd1 / 556726	ZFINID:	ZDB-GENE-110208-9	Length:	950	Species:	Danio rerio

Alignment Length:	765	Identity:	260/765 - (33%)
Similarity:	371/765 - (48%)	Gaps:	152/765 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 THINMDLSLTHEPANMQSQFGSFQNYDQFSAAGYSSTPLYITKPTGVGAITKVAPHCSQNKIETN 82
            ||....|    :|.:.|.|.|...     ||...|:...::.:|.|:        ...|..:..:
Zfish   224 THSRPQL----DPYSAQPQVGRMG-----SAVEISALQRFVPEPYGL--------EDDQRSLGYD 271

  Fly    83 STD---------NSIPDIENHPLATTVRYVQAGQYEDTSEYGVAGLTCGIDSEYTAEAVVPYCYT 138
            ..|         :::|.:.:...|...|  :.|.||.|.:..::|                   .
Zfish   272 EPDYGMGPAMHYSTMPRLAHPHHAPPPR--RTGSYEGTLDGDMSG-------------------A 315

  Fly   139 SDANYTGIQNTTSSIKPFSGRPFNDNINGAEAVADSQCRTFKSSAEFKLPQFAMSSINTVPQRLE 203
            .|..|.|           .|.|......|:.|..||..|        |.|
Zfish   316 GDMFYWG-----------GGAPLAQGERGSMASLDSTLR--------KGP--------------- 346

  Fly   204 EKDDYIEGSENDICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGG 268
                          :...||.|.|.|||:.|:.....:|:|||||||||.:.:|..|...|.|.|
Zfish   347 --------------APTAWRQPELPEVIAMLNYRLDPVKSNAAAYLQHLTFKNDKVKSEVRRLKG 397

  Fly   269 IPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVT 333
            ||.||.:|.....|:|..|||||:|:||||..| ||..|||..||.|||.||.::::.::.:.:|
Zfish   398 IPALVSMLDNPKKEVHYAACGALKNISYGRDPD-NKIAIKNCDGIPALVRLLRKTRDQDLTDTIT 461

  Fly   334 GVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGWDAVCCG--ETC------FSTVFRNASGVLR 390
            |.|||:||.:.:|..|:|.||.|:...|:.|||||:....|  |:|      :.|...|.:|.||
Zfish   462 GTLWNLSSHDSVKMEIVDHALHALSDEVMVPHSGWERGNEGGEESCKPRHLEWETALTNTTGCLR 526

  Fly   391 NVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQEVDDPNYDK 455
            ||||....||..||.|..||:.|:|:|::.|...::.||.:||.||:||||||:... :.|..::
Zfish   527 NVSSERSEARRKLRECSGLVDSLMYIVQSQINCKDVDNKLIENSVCLLRNLSYQVHR-EIPGCER 590

  Fly   456 HPFITPERVIP-SSSKGENLGCFGTNK---------KKKEANNSDALNEYNISADYSKSSVTYNK 510
            :....|....| .|.||   |||.:.|         |:::...||.:       |..|.:..
Zfish   591 YLESIPVNQGPLPSQKG---GCFSSRKGKDEWFSKGKREDDGTSDTI-------DIPKRTTP--- 642

  Fly   511 LNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSIDIRATVRKEKGLPILV 575
             .||||.|:|||||:.|.|||:...||..|||||||:|||.|..|.....||||:|:|.|||::.
Zfish   643 -AKGYELLFQPEVVRVYTSLLKESKNPSVLEAAAGAVQNLCAGRWTYGRYIRATMRQEHGLPMMT 706

  Fly   576 ELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLP-SGNVQHDQNTSDDTITAVLA 639
            |||....||||.|::.||||||||.||:||:||:|:.:||..|| .|..|..:..|::|:.:||:
Zfish   707 ELLSHGNDRVVRAMSGALRNLAIDARNRELLGKHAVPNLVANLPGGGQSQPARALSEETVVSVLS 771

  Fly   640 TINEVIKKNPEFSRSLLDSGGIDRLMNITKRKEKYTSCVLKFASQVLYTMWQHNELRDVYKKNGW 704
            |:.||:..:.:.:::|..:.||:||:.|.|...: :...::.|..||..:|...|||...:|:||
Zfish   772 TMAEVVGSSVDAAKTLRSAQGIERLVLINKDSNR-SDREVRGAGLVLQIVWGFKELRRTLEKDGW 835

  Fly   705 KEQDFVSKHFTAHNTPPSSPNNVNNTLNRPMASQGRTRYEDRT---IQRG 751
            |:.||:                ||  ||.|..::....||:.|   |.||
Zfish   836 KKTDFM----------------VN--LNPPNNTRSNGGYEESTLPLIDRG 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	55/113 (49%)
		armadillo repeat	227..252	CDD:293788	13/24 (54%)
		armadillo repeat	260..296	CDD:293788	17/35 (49%)
		armadillo repeat	304..339	CDD:293788	15/34 (44%)
		ARM	307..442	CDD:237987	61/142 (43%)
		armadillo repeat	347..392	CDD:293788	19/52 (37%)
		armadillo repeat	515..556	CDD:293788	25/40 (63%)
		ARM	516..643	CDD:237987	68/127 (54%)
		armadillo repeat	562..596	CDD:293788	19/33 (58%)
		armadillo repeat	601..641	CDD:293788	17/40 (43%)
ctnnd1	XP_021332609.1	armadillo repeat	356..381	CDD:293788	13/24 (54%)
		Arm	385..424	CDD:278915	18/38 (47%)
		armadillo repeat	389..425	CDD:293788	17/35 (49%)
		ARM	428..469	CDD:214547	18/41 (44%)
		armadillo repeat	432..467	CDD:293788	15/34 (44%)
		armadillo repeat	474..528	CDD:293788	20/53 (38%)
		armadillo repeat	646..683	CDD:293788	24/36 (67%)
		Arm	647..683	CDD:278915	23/35 (66%)
		ARM	693..728	CDD:214547	20/34 (59%)
		armadillo repeat	693..727	CDD:293788	19/33 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583610
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1698
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.900