DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment p120ctn and PKP1

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	NP_000290.2	Gene:	PKP1 / 5317	HGNCID:	9023	Length:	747	Species:	Homo sapiens

Alignment Length:	715	Identity:	185/715 - (25%)
Similarity:	305/715 - (42%)	Gaps:	130/715 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SLTHEPANMQ-SQFGSFQNYDQFSAAGYSSTPLYITKPTGVGAITKVAPHCSQNKIETNSTDNSI 88
            :|..||.|.: |.:...:|:.:....|..:|       ||.|     :..|...||:.:.::
Human   107 TLKREPDNRRFSSYSQMENWSRHYPRGSCNT-------TGAG-----SDICFMQKIKASRSE--- 156

  Fly    89 PDIENHPLATTVRYV--QAGQYEDTSEYGVAGLTCGIDSEYTAEAVVPYCYT-SDANYTGIQNTT 150
            ||:...|..|..:..  ..||....:.|.......|..:........|.|.: .|..|
Human   157 PDLYCDPRGTLRKGTLGSKGQKTTQNRYSFYSTCSGQKAIKKCPVRPPSCASKQDPVY------- 214

  Fly   151 SSIKPFSGRPFNDNINGAEAVADSQ-CRTFKSSAEFKLPQFAMSSINTVPQRLEEKDDYIEGSEN 214
              |.|.|   .|.:::...:.|.|: |                                   ||:
Human   215 --IPPIS---CNKDLSFGHSRASSKIC-----------------------------------SED 239

  Fly   215 DICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPLVRLLSYD 279
            ..||.:     .:.:.:.:||:.....:|..|.|:||.|:.|:..||:...||||..||.||...
Human   240 IECSGL-----TIPKAVQYLSSQDEKYQAIGAYYIQHTCFQDESAKQQVYQLGGICKLVDLLRSP 299

  Fly   280 SPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLWNMSSCED 344
            :..:.:.|.||||||.:  ::..||...:...||...|.||.|:...|:::.:||:|||:||.::
Human   300 NQNVQQAAAGALRNLVF--RSTTNKLETRRQNGIREAVSLLRRTGNAEIQKQLTGLLWNLSSTDE 362

  Fly   345 LKRSIIDEALVAVVCSVIKPHSGWDAVCCGETCFS------TVFRNASGVLR------------- 390
            ||..:|.:||..:...||.|.|||   |.|.:..|      .||.||:|.||
Human   363 LKEELIADALPVLADRVIIPFSGW---CDGNSNMSREVVDPEVFFNATGCLRKRLGMRELLALVP 424

  Fly   391 --------NVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQE 447
                    |:||| :..|..:||...|::.|:..|:..:..:...:|:||||:|:|.|||||...
Human   425 QRATSSRVNLSSA-DAGRQTMRNYSGLIDSLMAYVQNCVAASRCDDKSVENCMCVLHNLSYRLDA 488

  Fly   448 VDDPNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEANNSDALNEYNISADYSKSSVTYNKLN 512
            .....|.:..:.........||    .||| :||..|..||:     |:......:::      .
Human   489 EVPTRYRQLEYNARNAYTEKSS----TGCF-SNKSDKMMNNN-----YDCPLPEEETN------P 537

  Fly   513 KGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSIDIRATV-RKEKGLPILVE 576
            ||...|:..:.::.||:|:.......||||.|||:|||:|.....|..:...: .||||||.:..
Human   538 KGSGWLYHSDAIRTYLNLMGKSKKDATLEACAGALQNLTASKGLMSSGMSQLIGLKEKGLPQIAR 602

  Fly   577 LLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQHDQNT--SDDTITAVLA 639
            ||:.....||.:.|:.|.|::.......::|.....::.:.|.|    |..||  |:|.:::...
Human   603 LLQSGNSDVVRSGASLLSNMSRHPLLHRVMGNQVFPEVTRLLTS----HTGNTSNSEDILSSACY 663

  Fly   640 TINEVIKKNPEFSRSLLDSGGIDRLMNITKRKEKYTSCVLKFASQVLYTMWQHNELRDVYKKNGW 704
            |:..::...|:.::....|..::.::|:.:......:.  :.|..:|..||...||:.|.::.|:
Human   664 TVRNLMASQPQLAKQYFSSSMLNNIINLCRSSASPKAA--EAARLLLSDMWSSKELQGVLRQQGF 726

Fly 705 704
Human 727 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	40/113 (35%)
		armadillo repeat	227..252	CDD:293788	6/24 (25%)
		armadillo repeat	260..296	CDD:293788	17/35 (49%)
		armadillo repeat	304..339	CDD:293788	12/34 (35%)
		ARM	307..442	CDD:237987	53/161 (33%)
		armadillo repeat	347..392	CDD:293788	19/71 (27%)
		armadillo repeat	515..556	CDD:293788	15/40 (38%)
		ARM	516..643	CDD:237987	38/129 (29%)
		armadillo repeat	562..596	CDD:293788	12/34 (35%)
		armadillo repeat	601..641	CDD:293788	8/41 (20%)
PKP1	NP_000290.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..68
		ARM	238..359	CDD:237987	43/127 (34%)
		armadillo repeat	239..272	CDD:293788	8/37 (22%)
		ARM 1	243..274		8/35 (23%)
		ARM 2	275..316		18/40 (45%)
		armadillo repeat	280..316	CDD:293788	17/35 (49%)
		ARM 3	317..359		14/41 (34%)
		armadillo repeat	322..357	CDD:293788	12/34 (35%)
		ARM 4	360..415		21/57 (37%)
		ARM 5	416..463		10/47 (21%)
		ARM 6	525..556		6/41 (15%)
		ARM	542..670	CDD:237987	38/131 (29%)
		ARM 7	557..603		18/45 (40%)
		armadillo repeat	589..624	CDD:293788	13/34 (38%)
		ARM 8	604..649		10/48 (21%)
		armadillo repeat	630..668	CDD:293788	9/41 (22%)
		ARM 9	650..713		11/64 (17%)
		armadillo repeat	677..707	CDD:293788	3/31 (10%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149483
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.800