DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment p120ctn and ARVCF

DIOPT Version :9

Sequence 1:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster
Sequence 2:	XP_006724306.1	Gene:	ARVCF / 421	HGNCID:	728	Length:	1004	Species:	Homo sapiens

Alignment Length:	666	Identity:	265/666 - (39%)
Similarity:	372/666 - (55%)	Gaps:	81/666 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 TTSSIKPFSG-----RPFNDNINGAEAVADSQCRTFKSSAEFKLPQ-FAMSSINTVPQRLEEKDD 207
            |.:..:|..|     |.:.|..:....:||.:......:|....|: .:|.|::    ||..:..
Human   284 TATRRRPECGRGLHTRAYEDTADDGGELADERPAFPMVTAPLAQPERGSMGSLD----RLVRRSP 344

  Fly   208 YIEGSENDICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHLCYMDDPNKQRTRSLGGIPPL 272
            .::.:..:    .|||||.|.||::.|.:|...:||||||||||||:.::..|:|.|.|.|:|.|
Human   345 SVDSARKE----PRWRDPELPEVLAMLRHPVDPVKANAAAYLQHLCFENEGVKRRVRQLRGLPLL 405

  Fly   273 VRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALVHLLCRSQETEVKELVTGVLW 337
            |.||.:...|:.:.||||||||||||..| ||..|::.||:.|||.||..:::.||:|||||.||
Human   406 VALLDHPRAEVRRRACGALRNLSYGRDTD-NKAAIRDCGGVPALVRLLRAARDNEVRELVTGTLW 469

  Fly   338 NMSSCEDLKRSIIDEALVAVVCSVIKPHSGW-----------DAVCCGETCFSTVFRNASGVLRN 391
            |:||.|.||..|||..|..:...||.|||||           ||.      ::|||:|.||.|||
Human   470 NLSSYEPLKMVIIDHGLQTLTHEVIVPHSGWEREPNEDSKPRDAE------WTTVFKNTSGCLRN 528

  Fly   392 VSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLSYRCQEVDDPNYDKH 456
            |||.|..||..||.||.||:.||:.:::::.:.:..||:|||||||:|||||...: :.|..|::
Human   529 VSSDGAEARRRLRECEGLVDALLHALQSAVGRKDTDNKSVENCVCIMRNLSYHVHK-EVPGADRY 592

  Fly   457 PFITP----ERVIPSSSKGENLGCFGTNKKKKE---ANNSDALNEYNI-SADYSKSSVTYNKLNK 513
            ....|    ..|.....:.::..|||..|.|:|   ....|...:.|. :.|..|.:    :..|
Human   593 QEAEPGPLGSAVGSQRRRRDDASCFGGKKAKEEWFHQGKKDGEMDRNFDTLDLPKRT----EAAK 653

  Fly   514 GYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSIDIRATVRKEKGLPILVELL 578
            |:|.|:|||||:.|||||....|..||||||||:|||||..|..:..||||||||:|||:|||||
Human   654 GFELLYQPEVVRLYLSLLTESRNFNTLEAAAGALQNLSAGNWMWATYIRATVRKERGLPVLVELL 718

  Fly   579 RMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQHDQN-------TSDDTITA 636
            :.|.|:||.|||.|||||::|:|||:|||.|||.:||:     ||::.|.       ..:||:.|
Human   719 QSETDKVVRAVAIALRNLSLDRRNKDLIGSYAMAELVR-----NVRNAQAPPRPGACLEEDTVVA 778

  Fly   637 VLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRKEKYTSCVLKFASQVLYTMWQHNELRDVYKK 701
            ||.||:|::..:.:.:||||.:.|:..|:.:....:.....  |.||.||.|:|.:.|||...:|
Human   779 VLNTIHEIVSDSLDNARSLLQARGVPALVALVASSQSVREA--KAASHVLQTVWSYKELRGTLQK 841

  Fly   702 NGWKEQDFVSKHFTAHNTPPS-SPNNVNN--------------TLNR---PMASQGRTRYE--DR 746
            :||.:..|.|...||.....: ||...::              |.:|   ||.:.|...|.  ||
Human   842 DGWTKARFQSAAATAKGPKGALSPGGFDDSTLPLVDKSLEGEKTGSRDVIPMDALGPDGYSTVDR 906

  Fly   747 TIQ--RGTSTLYSAND 760
            ..:  ||.|:...|::
Human   907 RERRPRGASSAGEASE 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	61/113 (54%)
		armadillo repeat	227..252	CDD:293788	14/24 (58%)
		armadillo repeat	260..296	CDD:293788	19/35 (54%)
		armadillo repeat	304..339	CDD:293788	18/34 (53%)
		ARM	307..442	CDD:237987	70/145 (48%)
		armadillo repeat	347..392	CDD:293788	21/55 (38%)
		armadillo repeat	515..556	CDD:293788	26/40 (65%)
		ARM	516..643	CDD:237987	77/133 (58%)
		armadillo repeat	562..596	CDD:293788	25/33 (76%)
		armadillo repeat	601..641	CDD:293788	19/46 (41%)
ARVCF	XP_006724306.1	ARM	355..473	CDD:237987	65/118 (55%)
		HEAT_2	360..462	CDD:290374	53/102 (52%)
		armadillo repeat	360..385	CDD:293788	14/24 (58%)
		armadillo repeat	393..429	CDD:293788	19/35 (54%)
		armadillo repeat	436..471	CDD:293788	18/34 (53%)
		ARM	437..579	CDD:237987	70/147 (48%)
		armadillo repeat	478..529	CDD:293788	22/56 (39%)
		ARM	656..756	CDD:237987	66/99 (67%)
		armadillo repeat	656..692	CDD:293788	24/35 (69%)
		armadillo repeat	702..736	CDD:293788	25/33 (76%)
		armadillo repeat	743..788	CDD:293788	20/49 (41%)
		armadillo repeat	794..826	CDD:293788	9/33 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I6339
eggNOG	1	0.900	-	-		E1_KOG1048
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	401	1.000	Inparanoid score	I1931
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41407
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	1	1.000	-	-		X765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	9.000